Six-week versus twelve-week antibiotic therapy for nonsurgically treated diabetic foot osteomyelitis: A multicenter open-label controlled randomized study

Diabetes Care

Volumn 38, Issue 2, 2015, Pages 302-307

  Tone, Alina ^a   Nguyen, Sophie ^a   Devemy, Fabrice ^b   Topolinski, Hélène ^c   Valette, Michel ^a   Cazaubiel, Marie ^a   Fayard, Armelle ^d   Beltrand, Éric ^a   Lemaire, Christine ^c   Senneville, Éric ^a  

^a Gustave Dron Hospital   (France)

^b Lens Hospital   (France)

^c University Hospital Bethune   (France)

^d Arras General Hospital   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CEFEPIME; CEFOTAXIME; CEFTRIAXONE; CIPROFLOXACIN; COTRIMOXAZOLE; DOXYCYCLINE; LEVOFLOXACIN; LINEZOLID; RIFAMPICIN; ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE;

ACUTE KIDNEY FAILURE; ADULT; ANTIBIOTIC THERAPY; ARTICLE; BONE RESECTION; CHOLESTASIS; CLINICAL ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CYTOLYTIC HEPATITIS; DIABETIC FOOT; DIARRHEA; DIZZINESS; FEMALE; FOLLOW UP; FRANCE; HUMAN; LEG AMPUTATION; MALE; MULTICENTER STUDY; NAUSEA; NONHUMAN; OPEN STUDY; OSTEOMYELITIS; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RECURRENT INFECTION; REMISSION; SIX WEEK ANTIBIOTIC THERAPY; SKIN ALLERGY; THRUSH; TREATMENT DURATION; TWELVE WEEK ANTIBIOTIC THERAPY; VOMITING; WOUND HEALING; AMPUTATION; CLINICAL TRIAL; COMPARATIVE STUDY; COMPLICATION; DRUG ADMINISTRATION; DRUG COMBINATION; DRUG EFFECTS; MIDDLE AGED; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME;

AMPUTATION; ANTI-BACTERIAL AGENTS; DIABETIC FOOT; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; FLUOROQUINOLONES; HUMANS; MALE; MIDDLE AGED; OSTEOMYELITIS; PROSPECTIVE STUDIES; RIFAMPIN; TREATMENT OUTCOME; WOUND HEALING;

EID: 84921900161     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc14-1514     Document Type: Article

References (27)

1. Jeffcoate WJ, Lipsky BA. Controversies in diagnosing and managing osteomyelitis of the foot in diabetes. Clin Infect Dis 2004;39(Suppl. 2):S115-S122
2. Venkatesan P, Lawn S, Macfarlane RM, Fletcher EM, Finch RG, Jeffcoate WJ. Conservative management of osteomyelitis in the feet of diabetic patients. Diabet Med 1997;14:487-490
3. Senneville E, Yazdanpanah Y, Cazaubiel M, et al. Rifampicin-ofloxacin oral regimen for the treatment of mild to moderate diabetic foot osteomyelitis. J Antimicrob Chemother 2001;48:927-930
4. Pittet D, Wyssa B, Herter-Clavel C, Kursteiner K, Vaucher J, Lew PD. Outcome of diabetic foot infections treated conservatively: a retrospective cohort study with long-term follow-up. Arch Intern Med 1999;159:851-856
5. Yadlapalli N, Vaishnar A, Sheehan P. Conservative management of diabetic foot ulcers complicated by osteomyelitis. Wounds 2002;14:31-35
6. Embil JM, Rose G, Trepman E, et al. Oral antimicrobial therapy for diabetic foot osteomyelitis. Foot Ankle Int 2006;27:771-779
7. Lázaro-Martínez JL, Aragón-Sánchez J, García-Morales E. Antibiotics versus conservative surgery for treating diabetic foot osteomyelitis: a randomized comparative trial. Diabetes Care 2014;37:789-795
8. Lipsky BA, Berendt AR, Cornia PB, et al. 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis 2012;54:132-173
9. Senneville E, Lombart A, Beltrand E, et al. Outcome of diabetic foot osteomyelitis treated nonsurgically: a retrospective cohort study. Diabetes Care 2008;31:637-642
10. Senneville E, Melliez H, Beltrand E, et al. Culture of percutaneous bone biopsy specimens for diagnosis of diabetic foot osteomyelitis: concordance with ulcer swab cultures. Clin Infect Dis 2006;42:57-62
11. Spellberg B, Lipsky BA. Systemic antibiotic therapy for chronic osteomyelitis in adults. Clin Infect Dis 2012;54:393-407
12. Conterno LO, Da Silva Filho CR. Antibiotics for treating chronic osteomyelitis in adults. Cochrane Database Syst Rev 2009;3:CD004439
13. Chen TC, Lu PL, Lin WR, Lin CY, Wu JY, Chen YH. Rifampin-associated pseudomembranous colitis. Am J Med Sci 2009;338:156-158
14. Rice LB. The Maxwell Finland Lecture: for the duration-rational antibiotic administration in an era of antimicrobial resistance and clostridium difficile. Clin Infect Dis 2008;46:491-496
15. Hayashi Y, Paterson DL. Strategies for reduction in duration of antibiotic use in hospitalized patients. Clin Infect Dis 2011;52:1232-1240
16. Berendt AR, Peters EJ, Bakker K, et al. Specific guidelines for treatment of diabetic foot osteomyelitis. Diabetes Metab Res Rev 2008;24(Suppl. 1):S190-S191
17. Hartemann-Heurtier A, Senneville E. Diabetic foot osteomyelitis. Diabetes Metab 2008;34:87-95
18. Tice AD, Hoaglund PA, Shoultz DA. Outcomes of osteomyelitis among patients treated with outpatient parenteral antimicrobial therapy. Am J Med 2003;114:723-728
19. Korda J, Mezõ T R, Bálint GP. Treatment of musculoskeletal infections of the foot in patients with diabetes. Therapy 2005;2:287-300
20. Margolis DJ, Allen-Taylor L, Hoffstad O, Berlin JA. Diabetic neuropathic foot ulcers and amputation. Wound Repair Regen 2005;13:230-236
21. Kessler L, Piemont Y, Ortega F, et al. Comparison of microbiological results of needle puncture vs. superficial swab in infected diabetic foot ulcer with osteomyelitis. Diabet Med 2006;23:99-102
22. Aragón-Sánchez J, Lázaro-Martínez JL, Quintana-Marrero Y, et al. Are diabetic foot ulcers complicated by MRSA osteomyelitis associated with worse prognosis? Outcomes of a surgical series. Diabet Med 2009;26:552-555
23. Kaye KS, Engemann JJ, Fraimow HS, Abrutyn E. Pathogens resistant to antimicrobial agents: epidemiology, molecular mechanisms, and clinical management. Infect Dis Clin North Am 2004;18:467-511, viii
24. Mwangi MM, Wu SW, Zhou Y, et al. Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing. Proc Natl Acad Sci U S A 2007;104:9451-9456
25. Weiner RD, Viselli SJ, Fulkert KA, Accetta P. Histology versus microbiology for accuracy in identification of osteomyelitis in the diabetic foot. J Foot Ankle Surg 2011;50:197-200
26. Meyr AJ, Singh S, Zhang X, et al. Statistical reliability of bone biopsy for the diagnosis of diabetic foot osteomyelitis. J Foot Ankle Surg 2011;50:663-667
27. Lew DP, Waldvogel FA. Osteomyelitis. Lancet 2004;364:369-379