MALDI mass spectrometry imaging of lipids and primary metabolites on rat brain sections

Mass Spectrometry Imaging of Small Molecules

Volumn , Issue , 2014, Pages 41-48

  Touboul, David ^a   Brunelle, Alain ^a  

^a CNRS   (France)

Author keywords

Lipid; Mass spectrometry imaging; Matrix assisted laser desorption ionization; Primary metabolite; Tandem mass spectrometry; Time of fight

Indexed keywords

BIOMOLECULES; DESORPTION; DRUG PRODUCTS; LIPIDS; MASS SPECTROMETRY; METABOLITES; NEGATIVE IONS; POSITIVE IONS; RATS; STRUCTURAL ANALYSIS;

MASS-SPECTROMETRY IMAGING; MATRIX ASSISTED LASER DESORPTION/IONIZATION; PRIMARY METABOLITE; TANDEM MASS SPECTROMETRY; TIME OF FIGHTS;

MOLECULAR IMAGING;

EID: 84921858055     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4939-1357-2_5     Document Type: Chapter

References (16)

1. Spengler B, Hubert M, Kaufmann R (1994) In: Proceedings of the 42nd Annual Conference on Mass Spectrometry and Allied Topics, Chicago, IL, p 1041
2. Caprioli RM, Farmer TB, Gile J (1997) Molecular imaging of biological samples:localization of peptides and proteins using MALDI- TOF MS. Anal Chem 69(23):4751-4760
3. Stoeckli M, Chaurand P, Hallahan DE et al (2001) Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues. Nat Med 7(4):493-496
4. Debois D, Smargiasso N, Demeure K et al (2013) MALDI in-source decay, from sequencing to imaging Top Curr Chem 331:117-141
5. Maier SK, Hahne H, Moghaddas Gholami A et al (2013) Comprehensive identification of proteins from MALDI imaging. Mol Cell Proteomics 12:2901-2910. doi: 10.1074/mcp.M113.027599
6. Touboul D, Laprévote O, Brunelle A (2011) Micrometric molecular histology of lipids by mass spectrometry imaging. Curr Opin Chem Biol 15(5):725-732
7. Fernández JA, Ochoa B, Fresnedo O et al (2011) Matrix-assisted laser desorption ionization imaging mass spectrometry in lipidomics. Anal Bioanal Chem 401(1):29-51
8. Benabdellah F, Touboul D, Brunelle A et al (2009) In situ primary metabolites localization on a rat brain section by chemical mass spectrometry imaging. Anal Chem 81(13):5557-5560
9. Guilhaus M (1995) Principles and instrumentation in time-of-flight mass spectrometry. Physical and instrumental concepts. J Mass Spectrom 30(11):1519-151532
10. Zubarev RA, Makarov A (2013) Orbitrap mass spectrometry. Anal Chem 85(11):5288-5296
11. Benabdellah F, Seyer A, Quinton L et al (2010) Mass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI versus nanometer resolution by TOFSIMS. Anal Bioanal Chem 396(1):151-162
12. Cerruti CD, Benabdellah F, Laprévote O et al (2012) MALDI imaging and structural analysis of rat brain lipid negative ions with 9- aminoacridine matrix. Anal Chem 84(5):2164-2171
13. Cerruti CD, Touboul D, Guérineau V et al (2011) MALDI imaging mass spectrometry of lipids by adding lithium salts to the matrix solution. Anal Bioanal Chem 401(1):75-87
14. Eltoum I, Fredenburgh J, Myers RB et al (2001) Introduction to the theory and practice of fixation of tissues. J Histotechnol 3(18):173-190
15. Schwamborn K, Krieg RC, Reska M et al (2007) Identifying prostate carcinoma by MALDIImaging. Int J Mol Med 20(2):155-159
16. Deutskens F, Yang J, Caprioli RM (2011) High spatial resolution imaging mass spectrometry and classical histology on a single tissue section. J Mass Spectrom 46(6):568-571