Tumor deposits in rectal adenocarcinoma after neoadjuvant chemoradiation are associated with poor prognosis

Modern Pathology

Volumn 27, Issue 9, 2014, Pages 1281-1287

  Gopal, Purva ^a   Lu, Pengcheng ^b   Ayers, Gregory D ^b   Herline, Alan J ^b   Washington, Mary K ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Neoadjuvant treatment; Rectal carcinoma; Tumor deposits

Indexed keywords

ANTINEOPLASTIC AGENT;

ADJUVANT CHEMORADIOTHERAPY; ADJUVANT THERAPY; ADULT; AGED; ARTICLE; CANCER GRADING; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER REGRESSION; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; DISTANT METASTASIS; ENDOSCOPIC ULTRASONOGRAPHY; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; LYMPH VESSEL METASTASIS; MALE; MEDICAL RECORD REVIEW; OVERALL SURVIVAL; PRIORITY JOURNAL; RECTUM CARCINOMA; TREATMENT RESPONSE; TUMOR DEPOSIT; ADENOCARCINOMA; CHEMORADIOTHERAPY; FOLLOW UP; MIDDLE AGED; MORTALITY; PATHOLOGY; PROGNOSIS; RECTAL NEOPLASMS; RETROSPECTIVE STUDY; SURVIVAL RATE;

ADENOCARCINOMA; AGED; CHEMORADIOTHERAPY; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; PROGNOSIS; RECTAL NEOPLASMS; RETROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 84921827686     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2013.239     Document Type: Article

References (23)

1. Gabriel WB, Dukes CE, Bussy HJR. Lymphatic spread in cancer of the rectum. Br J Surg 1935;23:395-413.
2. Colon and Rectum. In: Fleming I, Cooper J, Henson D, Hutter R, Kennedy B, Murphy G, O'Sullivan B, Sobin L, Yarbro J (eds). AJCC Cancer Staging Manual, 5th edn. Lippincott-Raven: Philadelphia, 1997, pp 83-90.
3. Colon and Rectum. In: Greene F, Page D, Fleming I, Fritz A, Balch C, Haller D, Morrow M (eds). AJCC Cancer Staging Manual, 6th edn. Springer-Verlag: New York, 2002, pp 127-138.
4. Colon and Rectum. In: Edge S, Byrd D, Compton C, Fritz A, Greene F, Trotti A (eds). AJCC Cancer Staging Manual, 7th edn. Springer: New York, Dordrecht, Heidelberg, London, 2009, pp 143-164.
5. Song YX, Gao P, Wang ZN, et al. Can the tumor deposits be counted as metastatic lymph nodes in the UICC TNM staging system for colorectal cancer? PloS One 2012;7:e34087.
6. Ueno H, Mochizuki H, Shirouzu K, et al. Multicenter study for optimal categorization of extramural tumor deposits for colorectal cancer staging. Ann Surg 2012;255:739-746.
7. Nagtegaal ID, Quirke P. Colorectal tumour deposits in the mesorectum and pericolon; a critical review. Histopathology 2007;51:141-149.
8. Prabhudesai A, Arif S, Finlayson CJ, et al. Impact of microscopic extranodal tumor deposits on the outcome of patients with rectal cancer. Dis Colon Rectum 2003;46:1531-1537.
9. Wang Z, Zhou ZG, Wang C, et al. Microscopic spread of low rectal cancer in regions of mesorectum: pathologic assessment with whole-mount sections. WJG 2004;10:2949-2953.
10. Ueno H, Mochizuki H. Clinical significance of extra-bowel skipped cancer infiltration in rectal cancer. Surg Today 1997;27:617-622.
11. Ueno H, Mochizuki H, Tamakuma S. Prognostic significance of extranodal microscopic foci discontinuous with primary lesion in rectal cancer. Dis Colon Rectum 1998;41:55-61.
12. Ryan R, Gibbons D, Hyland JM, et al. Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Histopathology 2005;47:141-146.
13. Fine J, Gray R. A proportional hazards model for the subdistribution of a competing risk. J Am Statist Assoc 1999;94:496-509.
14. Gray R. A Class of K-sample tests for comparing the cumulative incidence of a competing risk. Ann Stat 1988;16:1141-1154.
15. Belt EJ, van Stijn MF, Bril H, et al. Lymph node negative colorectal cancers with isolated tumor deposits should be classified and treated as stage III. Ann Surg Oncol 2010;17:3203-3211.
16. Grotz TE, Mansfield AS, Kottschade LA, et al. In-transit melanoma: an individualized approach. Oncology. 2011;25:1340-1348.
17. Puppa G, Ueno H, Kayahara M, et al. Tumor deposits are encountered in advanced colorectal cancer and other adenocarcinomas: an expanded classification with implications for colorectal cancer staging system including a unifying concept of in-transit metastases. Modern Pathol 2009;22:410-415.
18. Puppa G, Sonzogni A, Colombari R, et al. TNM staging system of colorectal carcinoma: a critical appraisal of challenging issues. Arch Pathol Lab Med 2010;134:837-852.
19. Song JS, Chang HJ, Kim DY, et al. Is the N1c category of the new American Joint Committee on cancer staging system applicable to patients with rectal cancer who receive preoperative chemoradiotherapy? Cancer 2011;117:3917-3924.
20. Puppa G, Maisonneuve P, Sonzogni A, et al. Pathological assessment of pericolonic tumor deposits in advanced colonic carcinoma: relevance to prognosis and tumor staging. Modern Pathol 2007;20:843-855.
21. Shia J, Guillem JG, Moore HG, et al. Patterns of morphologic alteration in residual rectal carcinoma following preoperative chemoradiation and their association with long-term outcome. Am J Surg Pathol 2004;28:215-223.
22. Topova L, Hellmich G, Puffer E, et al. Prognostic value of tumor response to neoadjuvant therapy in rectal carcinoma. Dis Colon Rectum 2011;54:401-411.
23. Biondo S, Navarro M, Marti-Rague J, et al. Response to neoadjuvant therapy for rectal cancer: influence on long-term results. Colorectal Dis 2005;7:472-479.