Colectomy is a risk factor for venous thromboembolism in ulcerative colitis

World Journal of Gastroenterology

Volumn 21, Issue 4, 2015, Pages 1251-1260

  Kaplan, Gilaad G ^a,b   Lim, Allen ^a   Seow, Cynthia H ^a   Moran, Gordon W ^a   Ghosh, Subrata ^a   Leung, Yvette ^a   Debruyn, Jennifer ^a   Nguyen, Geoffrey C ^c,d   Hubbard, James ^a   Panaccione, Remo ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d INSTITUTE FOR CLINICAL EVALUATIVE SCIENCES   (Canada)

Author keywords

Deep vein thrombosis; Inflammatory bowel diseases; Pulmonary embolism; Surgery; Ulcerative colitis

Indexed keywords

AZATHIOPRINE; HEPARIN; INFLIXIMAB; LOW MOLECULAR WEIGHT HEPARIN; MERCAPTOPURINE; MESALAZINE; PREDNISONE; ANTICOAGULANT AGENT; GASTROINTESTINAL AGENT;

ADULT; ARTICLE; COLON RESECTION; DISEASE ACTIVITY; DISEASE DURATION; ELECTIVE SURGERY; FEMALE; HOSPITALIZATION; HUMAN; LOWER EXTREMITY DEEP VEIN THROMBOSIS; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MIDDLE AGED; OUTCOME ASSESSMENT; POPULATION RESEARCH; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATION; RISK FACTOR; SMOKING; THROMBOSIS PREVENTION; TREATMENT RESPONSE; ULCERATIVE COLITIS; VENOUS THROMBOEMBOLISM; ADOLESCENT; ADVERSE EFFECTS; COLITIS, ULCERATIVE; COMPARATIVE STUDY; COMPLICATION; EMERGENCY; MULTIVARIATE ANALYSIS; ODDS RATIO; STATISTICAL MODEL; TIME FACTOR; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; ANTICOAGULANTS; COLECTOMY; COLITIS, ULCERATIVE; ELECTIVE SURGICAL PROCEDURES; EMERGENCIES; FEMALE; GASTROINTESTINAL AGENTS; HEPARIN; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME; VENOUS THROMBOEMBOLISM; YOUNG ADULT;

EID: 84921758810     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v21.i4.1251     Document Type: Article

References (42)

1. Molodecky NA, Soon IS, Rabi DM, Ghali WA, Ferris M, Chernoff G, Benchimol EI, Panaccione R, Ghosh S, Barkema HW, Kaplan GG. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 2012; 142: 46-54.e42; quiz e30 [PMID: 22001864]
2. Frolkis AD, Dykeman J, Negrón ME, Debruyn J, Jette N, Fiest KM, Frolkis T, Barkema HW, Rioux KP, Panaccione R, Ghosh S, Wiebe S, Kaplan GG. Risk of surgery for inflammatory bowel diseases has decreased over time: a systematic review and metaanalysis of population-based studies. Gastroenterology 2013; 145: 996-1006 [PMID: 23896172 DOI: 10.1053/j.gastro.2013.07.041]
3. Kaplan GG, Seow CH, Ghosh S, Molodecky N, Rezaie A, Moran GW, Proulx MC, Hubbard J, MacLean A, Buie D, Panaccione R. Decreasing colectomy rates for ulcerative colitis: a populationbased time trend study. Am J Gastroenterol 2012; 107: 1879-1887 [PMID: 23165448 DOI: 10.1038/ajg.2012.333]
4. de Silva S, Ma C, Proulx MC, Crespin M, Kaplan BS, Hubbard J, Prusinkiewicz M, Fong A, Panaccione R, Ghosh S, Beck PL, Maclean A, Buie D, Kaplan GG. Postoperative complications and mortality following colectomy for ulcerative colitis. Clin Gastroenterol Hepatol 2011; 9: 972-980 [PMID: 21806954 DOI: 10.1016/j.cgh.2011.07.016]
5. Kaplan GG, McCarthy EP, Ayanian JZ, Korzenik J, Hodin R, Sands BE. Impact of hospital volume on postoperative morbidity and mortality following a colectomy for ulcerative colitis. Gastroenterology 2008; 134: 680-687 [PMID: 18242604 DOI: 10.1053/j.gastro.2008.01.004]
6. Soon IS, Wrobel I, deBruyn JC, Sauve R, Sigalet DL, Kaplan BS, Proulx MC, Kaplan GG. Postoperative complications following colectomy for ulcerative colitis in children. J Pediatr Gastroenterol Nutr 2012; 54: 763-768 [PMID: 22167014 DOI: 10.1097/MPG.0b013e318245265c]
7. Bernstein CN, Blanchard JF, Houston DS, Wajda A. The incidence of deep venous thrombosis and pulmonary embolism among patients with inflammatory bowel disease: a populationbased cohort study. Thromb Haemost 2001; 85: 430-434 [PMID: 11307809]
8. Kaplan GG, Hubbard J, Panaccione R, Shaheen AA, Quan H, Nguyen GC, Dixon E, Ghosh S, Myers RP. Risk of comorbidities on postoperative outcomes in patients with inflammatory bowel disease. Arch Surg 2011; 146: 959-964 [PMID: 21844437 DOI: 10.1001/archsurg.2011.194]
9. Solem CA, Loftus EV, Tremaine WJ, Sandborn WJ. Venous thromboembolism in inflammatory bowel disease. Am J Gastroenterol 2004; 99: 97-101 [PMID: 14687149]
10. Talbot RW, Heppell J, Dozois RR, Beart RW. Vascular complications of inflammatory bowel disease. Mayo Clin Proc 1986; 61: 140-145 [PMID: 3080643]
11. Jess T, Gamborg M, Munkholm P, Sørensen TI. Overall and cause-specific mortality in ulcerative colitis: meta-analysis of population-based inception cohort studies. Am J Gastroenterol 2007; 102: 609-617 [PMID: 17156150 DOI: 10.1111/j.1572-0241.2006.01000.x]
12. Miehsler W, Reinisch W, Valic E, Osterode W, Tillinger W, Feichtenschlager T, Grisar J, Machold K, Scholz S, Vogelsang H, Novacek G. Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism? Gut 2004; 53: 542-548 [PMID: 15016749]
13. Novacek G, Weltermann A, Sobala A, Tilg H, Petritsch W, Reinisch W, Mayer A, Haas T, Kaser A, Feichtenschlager T, Fuchssteiner H, Knoflach P, Vogelsang H, Miehsler W, Platzer R, Tillinger W, Jaritz B, Schmid A, Blaha B, Dejaco C, Eichinger S. Inflammatory bowel disease is a risk factor for recurrent venous thromboembolism. Gastroenterology 2010; 139: 779-787, 787.e1 [PMID: 20546736]
14. Kappelman MD, Horvath-Puho E, Sandler RS, Rubin DT, Ullman TA, Pedersen L, Baron JA, Sørensen HT. Thromboembolic risk among Danish children and adults with inflammatory bowel diseases: a population-based nationwide study. Gut 2011; 60: 937-943 [PMID: 21339206 DOI: 10.1136/gut.2010.228585]
15. Grainge MJ, West J, Card TR. Venous thromboembolism during active disease and remission in inflammatory bowel disease: a cohort study. Lancet 2010; 375: 657-663 [PMID: 20149425 DOI: 10.1016/S0140-6736(09)61963-2]
16. Nguyen GC, Sam J. Rising prevalence of venous thromboembolism and its impact on mortality among hospitalized inflammatory bowel disease patients. Am J Gastroenterol 2008; 103: 2272-2280 [PMID: 18684186 DOI: 10.1111/j.1572-0241.2008.02052.x]
17. Yuhara H, Steinmaus C, Corley D, Koike J, Igarashi M, Suzuki T, Mine T. Meta-analysis: the risk of venous thromboembolism in patients with inflammatory bowel disease. Aliment Pharmacol Ther 2013; 37: 953-962 [PMID: 23550660 DOI: 10.1111/apt.12294]
18. Murthy SK, Nguyen GC. Venous thromboembolism in inflammatory bowel disease: an epidemiological review. Am J Gastroenterol 2011; 106: 713-718 [PMID: 21407182 DOI: 10.1038/ajg.2011.53]
19. Wallaert JB, De Martino RR, Marsicovetere PS, Goodney PP, Finlayson SR, Murray JJ, Holubar SD. Venous thromboembolism after surgery for inflammatory bowel disease: are there modifiable risk factors? Data from ACS NSQIP. Dis Colon Rectum 2012; 55: 1138-1144 [PMID: 23044674 DOI: 10.1097/DCR.0b013e3182698f60]
20. Nguyen GC, Wu H, Gulamhusein A, Rosenberg M, Thanabalan R, Yeo EL, Bernstein CN, Steinhart AH, Margolis M. The utility of screening for asymptomatic lower extremity deep venous thrombosis during inflammatory bowel disease flares: a pilot study. Inflamm Bowel Dis 2013; 19: 1053-1058 [PMID: 23429463 DOI: 10.1097/MIB.0b013e3182802a65]
21. Buchberg B, Masoomi H, Lusby K, Choi J, Barleben A, Magno C, Lane J, Nguyen N, Mills S, Stamos MJ. Incidence and risk factors of venous thromboembolism in colorectal surgery: does laparoscopy impart an advantage? Arch Surg 2011; 146: 739-743 [PMID: 21690452]
22. Merrill A, Millham F. Increased risk of postoperative deep vein thrombosis and pulmonary embolism in patients with inflammatory bowel disease: a study of National Surgical Quality Improvement Program patients. Arch Surg 2012; 147: 120-124 [PMID: 22006853]
23. Kornbluth A, Sachar DB. Ulcerative colitis practice guidelines in adults (update): American College of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol 2004; 99: 1371-1385 [PMID: 15233681 DOI: 10.1111/j.1572-0241.2004.40036.x]
24. Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR, Colwell CW. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133: 381S-453S [PMID: 18574271]
25. Chande N, McDonald JW, Macdonald JK, Wang JJ. Unfractionated or low-molecular weight heparin for induction of remission in ulcerative colitis. Cochrane Database Syst Rev 2010; (10): CD006774 [PMID: 20927749 DOI: 10.1002/14651858.CD006774.pub3]
26. Ra G, Thanabalan R, Ratneswaran S, Nguyen GC. Predictors and safety of venous thromboembolism prophylaxis among hospitalized inflammatory bowel disease patients. J Crohns Colitis 2013; 7: e479-e485 [PMID: 23537817 DOI: 10.1016/j.crohns.2013.03.002]
27. Tinsley A, Naymagon S, Enomoto LM, Hollenbeak CS, Sands BE, Ullman TA. Rates of pharmacologic venous thromboembolism prophylaxis in hospitalized patients with active ulcerative colitis: results from a tertiary care center. J Crohns Colitis 2013; 7: e635-e640 [PMID: 23706933 DOI: 10.1016/j.crohns.2013.05.002]
28. Tinsley A, Naymagon S, Trindade AJ, Sachar DB, Sands BE, Ullman TA. A survey of current practice of venous thromboembolism prophylaxis in hospitalized inflammatory bowel disease patients in the United States. J Clin Gastroenterol 2013; 47: e1-e6 [PMID: 22476043 DOI: 10.1097/MCG.0b013e31824c0dea]
29. Ma C, Crespin M, Proulx MC, DeSilva S, Hubbard J, Prusinkiewicz M, Nguyen GC, Panaccione R, Ghosh S, Myers RP, Quan H, Kaplan GG. Postoperative complications following colectomy for ulcerative colitis: a validation study. BMC Gastroenterol 2012; 12: 39 [PMID: 22943760 DOI: 10.1186/1471-230X-12-39]
30. Gould MK, Garcia DA, Wren SM, Karanicolas PJ, Arcelus JI, Heit JA, Samama CM. Prevention of VTE in nonorthopedic surgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141: e227S-e277S [PMID: 22315263]
31. Scarpa M, Pilon F, Pengo V, Romanato G, Ruffolo C, Erroi F, Elisa B, Frego M, Ossi E, Manzato E, Angriman I. Deep venous thrombosis after surgery for inflammatory bowel disease: is standard dose low molecular weight heparin prophylaxis enough? World J Surg 2010; 34: 1629-1636 [PMID: 20177681 DOI: 10.1007/s00268-010-0490-8]
32. McLeod RS, Geerts WH, Sniderman KW, Greenwood C, Gregoire RC, Taylor BM, Silverman RE, Atkinson KG, Burnstein M, Marshall JC, Burul CJ, Anderson DR, Ross T, Wilson SR, Barton P. Subcutaneous heparin versus low-molecular-weight heparin as thromboprophylaxis in patients undergoing colorectal surgery: results of the canadian colorectal DVT prophylaxis trial: a randomized, double-blind trial. Ann Surg 2001; 233: 438-444 [PMID: 11224634]
33. Choi S, Lee KW, Bang SM, Kim S, Lee JO, Kim YJ, Kim JH, Park YS, Kim DW, Kang SB, Kim JS, Oh D, Lee JS. Different characteristics and prognostic impact of deep-vein thrombosis / pulmonary embolism and intraabdominal venous thrombosis in colorectal cancer patients. Thromb Haemost 2011; 106: 1084-1094 [PMID: 22072215 DOI: 10.1160/TH11-07-0505]
34. Di Fabio F, Obrand D, Satin R, Gordon PH. Intra-abdominal venous and arterial thromboembolism in inflammatory bowel disease. Dis Colon Rectum 2009; 52: 336-342 [PMID: 19279432 DOI: 10.1007/DCR.0b013e31819a235d]
35. Kahn SR, Panju A, Geerts W, Pineo GF, Desjardins L, Turpie AG, Glezer S, Thabane L, Sebaldt RJ. Multicenter evaluation of the use of venous thromboembolism prophylaxis in acutely ill medical patients in Canada. Thromb Res 2007; 119: 145-155 [PMID: 16516275 DOI: 10.1016/j.thromres.2006.01.011]
36. Shen J, Ran ZH, Tong JL, Xiao SD. Meta-analysis: The utility and safety of heparin in the treatment of active ulcerative colitis. Aliment Pharmacol Ther 2007; 26: 653-663 [PMID: 17697199 DOI: 10.1111/j.1365-2036.2007.03418.x]
37. Järnerot G, Hertervig E, Friis-Liby I, Blomquist L, Karlén P, Grännö C, Vilien M, Ström M, Danielsson A, Verbaan H, Hellström PM, Magnuson A, Curman B. Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study. Gastroenterology 2005; 128: 1805-1811 [PMID: 15940615 DOI: 10.1053/j.gastro.2005.03.003]
38. Rutgeerts P, Sandborn WJ, Feagan BG, Reinisch W, Olson A, Johanns J, Travers S, Rachmilewitz D, Hanauer SB, Lichtenstein GR, de Villiers WJ, Present D, Sands BE, Colombel JF. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 2005; 353: 2462-2476 [PMID: 16339095]
39. Sandborn WJ, Rutgeerts P, Feagan BG, Reinisch W, Olson A, Johanns J, Lu J, Horgan K, Rachmilewitz D, Hanauer SB, Lichtenstein GR, de Villiers WJ, Present D, Sands BE, Colombel JF. Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab. Gastroenterology 2009; 137: 1250-1260; quiz 1520 [PMID: 19596014 DOI: 10.1053/j.gastro.2009.06.061]
40. Gustavsson A, Järnerot G, Hertervig E, Friis-Liby I, Blomquist L, Karlén P, Grännö C, Vilien M, Ström M, Verbaan H, Hellström PM, Magnuson A, Halfvarson J, Tysk C. Clinical trial: colectomy after rescue therapy in ulcerative colitis-3-year follow-up of the Swedish-Danish controlled infliximab study. Aliment Pharmacol Ther 2010; 32: 984-989 [PMID: 20937043 DOI: 10.1111/j.1365-2036.2010.04435.x]
41. Reinisch W, Sandborn WJ, Rutgeerts P, Feagan BG, Rachmilewitz D, Hanauer SB, Lichtenstein GR, de Villiers WJ, Blank M, Lang Y, Johanns J, Colombel JF, Present D, Sands BE. Long-term infliximab maintenance therapy for ulcerative colitis: the ACT-1 and-2 extension studies. Inflamm Bowel Dis 2012; 18: 201-211 [PMID: 21484965 DOI: 10.1002/ibd.21697]
42. Molodecky NA, Panaccione R, Ghosh S, Barkema HW, Kaplan GG. Challenges associated with identifying the environmental determinants of the inflammatory bowel diseases. Inflamm Bowel Dis 2011; 17: 1792-1799 [PMID: 21744435 DOI: 10.1002/ibd.21511]