Depression and antidepressant use moderate association between widowhood and Alzheimer 's disease

International Journal of Geriatric Psychiatry

Volumn 30, Issue 3, 2015, Pages 292-299

  Hatch, Daniel J ^a   Schwartz, Sarah ^a   Norton, Maria C ^a  

^a UTAH STATE UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Antidepressants; Depression; Widowhood

Indexed keywords

ANTIDEPRESSANT AGENT; APOLIPOPROTEIN E;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; DEPRESSION; DISEASE ASSOCIATION; DSM-III-R; FEMALE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; POLYMERASE CHAIN REACTION; POPULATION BASED CASE CONTROL STUDY; PREVALENCE; RISK FACTOR; UNITED STATES; WIDOW; COMPLICATION; DEPRESSIVE DISORDER; LIFE EVENT; MENTAL STRESS; PSYCHOLOGY; REGRESSION ANALYSIS; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTIDEPRESSIVE AGENTS; DEPRESSIVE DISORDER; FEMALE; HUMANS; INCIDENCE; LIFE CHANGE EVENTS; MALE; PREVALENCE; REGRESSION ANALYSIS; STRESS, PSYCHOLOGICAL; UTAH; WIDOWHOOD;

EID: 84921745197     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.4140     Document Type: Article

References (49)

1. Aartsen MJ, Van Tilburg T, Smits CHM, Comijs HC, Knipscheer KCPM. 2005. Does widowhood affect memory performance of older persons? Psychol Med 35: 217-226. doi: 10.1017/S0033291704002831
2. Bennett KM, Smith PT, Hughes GM. 2005. Coping, depressive feelings and gender differences in late life widowhood. Aging Ment Health 9(4): 348-353.
3. Bhagwagar Z, Hafizi S, Cowen P. 2005. Increased salivary cortisol after waking in depression. Psychopharmacology (Berl) 182 (1): 54-57. doi:10.1007/s00213-005-0062-z
4. Bosworth HB, Park K, McQuoid DR, Hays JC, Steffens DC. 2003. The impact of religious practice and religious coping on geriatric depression. Int J Geriatr Psychiatry 18(10): 905-914.
5. Bremner JD, Vythilingam M, Vermetten E, et al. 2003. MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder. Am J Psychiatry 160: 924-932.
6. Buckley T, Bartrop R, McKinley S, et al. 2009. Prospective study of early bereavement on psychological and behavioural cardiac risk factors. Intern Med J 39: 370-378. doi: 10.1111/j.1445-5994.2008.01879.x
7. Comijs HC, van den Kommer TN, Minnaar RWM, Penninx BWJH, Deeg DJH. 2011. Accumulated and differential effects of life events on cognitive decline in older persons: depending on depression, baseline cognition, or APOE e4 status? J Gerontol B Psychol Sci Soc Sci 66B(suppl 1): i111-i120. doi: 10.1093/geronb/gbr019
8. Ekstrand J, Hellsten J, Tingström A. 2008. Environmental enrichment, exercise and corticosterone affect endothelial cell proliferation in adult rat hippocampus and prefrontal cortex. Neurosci Lett 442 : 203-207.
9. Fratiglioni L, Wang H, Ericsson K, Maytan M, Winbald B. 2000. Influence of social network on occurrence of dementia: a community-based longitudinal study. Lancet 355: 1315-1319.
10. Garson GD. 2012. Cox Regression. Statistical Associates Publishers: Asheboro, NC.
11. Gerritsen L, Geerlings MI, Beekman, ATF, et al. 2009. Early and late life events and salivary cortisol in older persons. Psychol Med 40: 1569-1578. doi: 10.1017/S0033291709991863
12. Greenglass E, Fiksenbaum L, Eaton J. 2006. The relationship between coping, social support, functional disability and depression in the elderly. Anxiety Stress Coping 19(1): 15-31.
13. Hakansson K, Rovio S, Helkala E-L, et al. 2009. Association between mid-life marital status and cognitive function in later life: population based cohort study. Br Med J 339: 99-106. doi: 10.1136/bmj.b2462
14. Helmer C, Damon D, Letenneur L, et al. 1999. Marital status and risk of Alzheimer's disease. Neurology 53: 1953-1958.
15. Holmes TH, Rahe RH. 1967. The social readjustment scale. J Psychosom Res 11: 213-218.
16. Hughes ME, Waite, LJ. 2009. Marital biography and health at mid-life. J Health Soc Behav 50: 344-358. doi: 10.1177/002214650905000307
17. Jorm AF. 1994. A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): development and cross-validation. Psychol Med 24(1): 145-153.
18. Kang J-E, Cirrito JR, Dong H, Csernansky JG, Holtzman DM. 2007. Acute stress increases interstitial fluid amyloid-innodatabeta via corticotropin-releasing factor and neuronal activity. Proc Natl Acad Sci 104: 10673-10678. doi: 10.1073/pnas.0700148104
19. Karlamangla AS, Miller-Martinez D, Aneshensel CS, et al. 2009. Trajectories of cognitive function in late life in the United States: demographic and socioeconomic predictors. Am J Epidemiol 170: 331-342. doi: 10.1093/aje/kwp154
20. Kiss, P, De Meester, M, Braeckman, L 2008. Differences between younger and older workers in the need for recovery after work. Int Arch Occup Environ Health 81, 311-320. DOI 10.1007/s00420-007-0215-y
21. Kuningas M, de Rijk RH, Westendorp RJG, et al. 2007. Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors. Neuropsychopharmacology 32(6): 1295-1301. doi:10.1038/sj.npp.1301260
22. Lee HB, Norton MC, Corcoran C, et al. 2011, July. Widowhood is Associated With Faster Cognitive Decline: The Cache County Study. Paper presented at the The International Conference on Alzheimer's Disease: Paris, France.
23. Lobo A, Launer LJ, Fratiglioni L, et al . 2000. Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurol Dis Elderly Res Group Neurol 54: 4-9.
24. Luppa MM, Sikorski CC, Luck TT, et al . 2012. Age- and gender-specific prevalence of depression in latest-life- systematic review and meta-analysis. J Affect Disord 136 (3): 212-221. doi:10.1016/j.jad.2010.11.033.
25. Norton MC, Breitner JCS, Welsh KA, Wyse BW. 1994. Characteristics of nonresponders in a community survey of the elderly. J Am Geriatr Soc 42: 1252-1256.
26. Norton MC, Skoog I, Franklin LM, et al. 2006. Gender differences in the association between religious involvement and depression: the Cache County (Utah) Study. J Gerontol B Psychol Sci Soc Sci 61 (3): P129-P136.
27. Peavy GM, Lange KL, Salmon DP, et al. 2007. The effects of prolonged stress and APOE genotype on memory and cortisol in older adults. Biol Psychiatry 62: 472-478.
28. Pruessner M, Hellhammer DH, Pruessner JC, Lupien SJ. 2003. Self-reported depressive symptoms and stress levels in healthy young men: associations with the cortisol response to awakening. Psychosom Med 65: 92-99.
29. Ritvanen, T, Louhevaara, V, Helin, P, Väisänen, S, Hänninen, O. 2006. Responses of the autonomic nervous system during periods of perceived high and low work stress in younger and older female teachers. Appl Ergon 37: 311-318.
30. Robins LN, Helzer JE, Croughan J, Ratcliff KS. 1981. National Institute of Mental Health Diagnostic Interview Schedule: its history, characteristics, and validity. Arch Gen Psychiatry 38(4): 381-389.
31. Rosnick CB, Small BJ, Burton AM. 2010. The effect of spousal bereavement on cognitive functioning in a sample of older adults. Aging Neuropsyc Cogn 17: 257-269.
32. Rosnick CB, Small BJ, McEvoy CL, Borenstein AR, Mortimer JA. 2007. Negative life events and cognitive performance in a population of older adults. J Aging Health 19 : 612-629. doi: 10.1177/0898264307300975
33. Sachs-Ericsson NJ, Sawyer KA, Corsentino EA, Collins NA, Blazer DG. 2010. APOE e4 allele carriers: biological, psychological, and social variables associated with cognitive impairment. Aging Ment Health 14(6): 679-691.
34. Saunders AM, Strittmatter WJ, Schmechel D, et al. 1993. Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43 (8): 1467.
35. Shahar DR, Schultz R, Shahar A, Wing RR. 2001. The effect of widowhood on weight change, dietary intake, and eating behavior in the elderly population. J Aging Health 13: 186-199. doi: 10.1177/089826430101300202
36. Sheline YI, Gado MH, Kraemer HC. 2003. Untreated depression and hippocampal volume loss. Am J Psychiatry 160: 1516-1518. doi: 10.1176/appi.ajp.160.8.1516
37. Sotiropoulos I, Catania C, Pinto LG, et al . 2011. Stress acts cumulatively to precipitate Alzheimer's disease-like tau pathology and cognitive deficits. J Neurosci 31: 7840-7847. doi: 10.1523/jneurosci.0730-11.2011
38. Sousa N, Madeira MD, Paula-Barbosa MM. 1998. Effects of corticosterone treatment and rehabilitation on the hippocampal formation of neonatal and adult rats. An unbiased stereological study. Brain Res 794: 199-210.
39. Teri L, Ferretti LE. 1999. Anxiety in Alzheimer's disease: prevalence and comorbidity. J Gerontol A Biol Sci Med Sci 54A(7): M348-M352.
40. Tschanz JT, Welsh-Bohmer KA, Plassman BL, et al. 2002. An adaptation of the Modified Mini-Mental State Examination: analysis of demographic influences and normative data: the Cache County Study. Cogn Behav Neurol 15(1): 28-38.
41. Van Gelder BM, Tijhuis M, Kalmijn S, et al. 2006. Marital status and living situation during a 5-year period are associated with a subsequent 10-year cognitive decline in older men: the FINE study. J Gerontol B Psychol Sci Soc Sci 61 : P213-P219.
42. van Leeuwen N, Kumsta R, Entringer S, et al. 2010. Functional mineralocorticoid receptor (MR) gene variation influences the cortisol awakening response after dexamethasone. Psychoneuroendocrinology 35(3): 339-349. doi:10.1016/j.psyneuen.2009.07.006
43. Velders FP, Kuningas M, Kumari M, et al. 2011. Genetics of cortisol secretion and depressive symptoms: a candidate gene and genome wide association approach. Psychoneuroendocrinology 36(7): 1053-1061. doi:10.1016/j.psyneuen.2011.01.003
44. Vreeburg SA, Hoogendijk WJG, van Pelt J, et al. 2009. Major depressive disorder and hypothalamic-pituitary-adrenal axis activity. Arch Gen Psychiatry 66(6): 617-626.
45. Ward L, Mathias JL, Hitchings SE. 2007. Relationships between bereavement and cognitive functioning in older adults. Gerontology 53: 362-372.
46. Wilson RS, Barnes LL, Bennett DA, et al. 2005. Proneness to psychological distress and risk of Alzheimer disease in a biracial community. Neurology 64: 380-382.
47. Wilson RS, Scheider JA, Boyle PA, et al. 2007. Chronic distress and incidence of mild cognitive impairment. Neurology 68: 2085-2092.
48. U.S. Department of Labor. 1991. Dictionary of Occupational Titles. Washington, D.C.: U.S. Government Printing Office.
49. Zobel A, Schuhmacher A, Jessen F, et al. 2010. DNA sequence variants of the FKBP5 gene are associated with unipolar depression. Int J Neuropsychopharmacol 13: 649-660.