Trafficking and Function of GPCRs in the Endosomal Compartment

Methods in Molecular Biology

Volumn 1234, Issue , 2015, Pages 197-211

  Calebiro, Davide ^a   Godbole, Amod ^a   Lyga, Sandra ^a   Lohse, Martin J ^a  

^a NONE

Author keywords

Endocytosis inhibitor; Fluorescence resonance energy transfer; G protein coupled receptor; Highly inclined thin illumination; Thyroid follicle; Thyroid stimulating hormone; Thyroid stimulating hormone receptor; Total internal refl ection fl uorescence microscopy

Indexed keywords

CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; LIGAND;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL SUSPENSION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; ENDOSOME; FEMALE; FLUORESCENCE MICROSCOPY; FLUORESCENCE RESONANCE ENERGY TRANSFER; ILLUMINATION; INTERNALIZATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRAFFICKING; SECOND MESSENGER; THYROID FOLLICLE; ANIMAL; CYTOLOGY; METABOLISM; MOLECULAR IMAGING; PRIMARY CELL CULTURE; PROCEDURES; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; THYROID GLAND;

ANIMALS; CYCLIC AMP; ENDOSOMES; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIGANDS; MICE; MICROSCOPY, FLUORESCENCE; MOLECULAR IMAGING; PRIMARY CELL CULTURE; PROTEIN TRANSPORT; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; THYROID GLAND;

EID: 84921735230     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-1755-6_16     Document Type: Article

References (11)

1. Lohse MJ, Nikolaev VO, Hein P et al (2008) Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors. Trends Pharmacol Sci 29:159–165
2. Calebiro D, Nikolaev VO, Gagliani MC et al (2009) Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. PLoS Biol 7:1000172
3. Müllershausen F, Zecri F, Cetin C et al (2009) Persistent signaling induced by FTY720- phosphate is mediated by internalized S1P1 receptors. Nat Chem Biol 5:428–434
4. Ferrandon S, Feinstein TN, Castro M et al (2009) Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nat Chem Biol 5:734–742
5. Irannejad R, Tomshine JC, Tomshine JR et al (2013) Conformational biosensors reveal GPCR signalling from endosomes. Nature 495:534–538
6. Calebiro D, Nikolaev VO, Persani L, Lohse MJ (2010) Signaling by internalized G-proteincoupled receptors. Trends Pharmacol Sci 31: 221–228
7. Lohse MJ, Calebiro D (2013) Cell biology: receptor signals come in waves. Nature 495: 457–458
8. Jacobs S, Calebiro D, Nikolaev VO et al (2010) Real-time monitoring of somatostatin receptorcAMP signaling in live pituitary. Endocrinology 151:4560–4565
9. Werthmann RC, Volpe S, Lohse MJ, Calebiro D (2012) Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells. FASEB J 26: 2043–2048
10. Nikolaev VO, Bünemann M, Hein L et al (2004) Novel single chain cAMP sensors for receptorinduced signal propagation. J Biol Chem 279: 37215–37218
11. Tokunaga M, Imamoto N, Sakata-Sogawa K (2008) Highly inclined thin illumination enables clear single-molecule imaging in cells. Nat Methods 5:159–161