Glutamate level in anterior cingulate predicts anxiety in healthy humans: A magnetic resonance spectroscopy study

Psychiatry Research - Neuroimaging

Volumn 224, Issue 1, 2014, Pages 34-41

  Modi, Shilpi ^a   Rana, Poonam ^a   Kaur, Prabhjot ^a   Rani, Nisha ^a   Khushu, Subash ^a  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

Hippocampus; Neuroimaging; State anxiety; Trait anxiety

Indexed keywords

GLUTAMIC ACID; GLUTAMINE; INOSITOL;

ADULT; AMINO ACID BRAIN LEVEL; ANTERIOR CINGULATE; ANXIETY; ARTICLE; ATTENTIONAL BIAS; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; DISTRACTIBILITY; DRUG DEPENDENCE; FEMALE; GLUTAMIC ACID BRAIN LEVEL; HEAD INJURY; HIPPOCAMPUS; HUMAN; HYPERTENSION; MALE; MENTAL DISEASE; NEUROCHEMISTRY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PREDICTIVE VALUE; PRIORITY JOURNAL; THREAT; YOUNG ADULT; CINGULATE GYRUS; DIAGNOSIS; METABOLISM;

ADULT; ANXIETY; FEMALE; GLUTAMIC ACID; GLUTAMINE; GYRUS CINGULI; HUMANS; INOSITOL; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PREDICTIVE VALUE OF TESTS; YOUNG ADULT;

EID: 84921694591     PISSN: 09254927     EISSN: 18727506     Source Type: Journal    
DOI: 10.1016/j.pscychresns.2014.03.001     Document Type: Article

References (40)

1. Arnold P.D., Rosenberg D.R., Mundo E., Tharmalingam S., Kennedy J.L., Richter M.A. Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study. Psychopharmacology (Berl) 2004, 174:530-538.
2. Baur V., Hänggi J., Jäncke L. Volumetric associations between uncinate fasciculus, amygdala, and trait anxiety. BMC Neuroscience 2012, 13:4.
3. Beck A.T., Steer R.A., Brown G.K. Beck Depression Inventory: Manual 1996, The Psychological Corporation, San Antonio, TX. second ed.
4. Bishop S.J., Duncan J., Brett M., Lawlence A.D. Prefrontal cortical function and anxiety: controlling attention to threat related stimuli. Nature Neuroscience 2004, 7(2):184-188.
5. Bishop S.J. Trait anxiety and impoverished prefrontal control of attention. Nature Neuroscience 2009, 12(1):92-98.
6. Cortese B.M., Phan K.L. The role of glutamate in anxiety and related disorders. CNS Spectrums 2005, 10(10):820-830.
7. Dager S.R., Friedman S.D., Heid A., Layton M.E., Richards T., Artru A., Strauss W., Hayes C., Posse S. Two-dimensional proton echo-planar spectroscopic imaging of brain metabolic changes during lactate-induced panic. Archives of General Psychiatry 1999, 56:70-77.
8. Delgado M.R., Nearing K.I., Ledoux J.E., Phelps E.A. Neural circuitry underlying the regulation of conditioned fear and its relation to extinction. Neuron 2008, 59:829-838.
9. Deshpande S.N., Mathur M.N.L., Das S.K., Bhatia T., Sharma S.D., Nimgaonkar V.L. A Hindi version of the diagnostic interview for genetic studies. Schizophrenia Bulletin 1998, 24(3):489-493.
10. Egner T., Etkin A., Gale S., Hirsch J. Dissociable neural systems resolve conflict from emotional versus nonemotional distracters. Cerebral Cortex 2008, 18:1475-1484.
11. Etkin A., Egner T., Kalisch R. Emotional processing in anterior cingulate and medial prefrontal cortex. Trends in Cognitive Sciences 2011, 15(2):85-93.
12. Eysenck M.W., Derakshan N., Santos R., Calvo M.G. Anxiety and cognitive performance: attentional control theory. Emotion 2007, 7(2):336-353.
13. Fan Q., Tan L., You C., Wang J., Ross C.A., Wang X., Zhang T., Li J., Chen K., Xiao Z. Increased N-acetylaspartate/creatine ratio in the medial prefrontal cortex among unmedicated obsessive-compulsive disorder patients. Psychiatry and Clinical Neurosciences 2010, 64(5):483-490.
14. First M.B., Spitzer R.L., Miriam G., Williams J.B.W. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient edition (SCID-I/P). Biometrics Research 2002, New York State Psychiatric Institute, New York, NY.
15. Grachev I.D., Apkarian A.V. Anxiety in healthy humans is associated with orbital frontal chemistry. Molecular Psychiatry 2000, 5:482-488.
16. Heckers S. Neuroimaging studies of the hippocampus in schizophrenia. Hippocampus 2001, 11(5):520-528.
17. Hermens D.F., Lagopoulos J., Naismith S.L., Tobias-Webb J., Hickie I.B. Distinct neurometabolic profiles are evident in the anterior cingulate of young people with major psychiatric disorders. Translational Psychiatry 2012, 2:e110.
18. Hettema J.M., Kettenmann B., Ahluwalia V., McCarthy C., Kates W.R., Schmitt J.E., Silberg J.L., Neale M.C., Kendler K,S., Fatouros P. A pilot multimodal twin imaging study of generalized anxiety disorder. Depression and Anxiety 2012, 29(3):202-209.
19. Hong S.B., Shin Y.W., Kim S.H., Yoo S.Y., Lee J.M., Kim I.Y., Kim S.I., Kwon J.S. Hippocampal shape deformity analysis in obsessive-compulsive disorder. European Archives of Psychiatry and Clinical Neurosciences 2007, 257(4):185-190.
20. Keshavan M.S., Kapur S., Pettegrew J.W. Magnetic resonance spectroscopy in psychiatry: potential, pitfalls, and promise. American Journal of Psychiatry 1991, 148(8):976-985.
21. Kimbrell T., Leulf C., Cardwell D., Komoroski R.A., Freeman T.W. Relationship of in vivo medial temporal lobe magnetic resonance spectroscopy to documented combat exposure in veterans with chronic posttraumatic stress disorder. Psychiatry Research: Neuroimaging 2005, 140(1):91-94.
22. Lieberman M.D., Eisenberger N.I., Crockett M.J., Tom S.M., Pfeifer J.H., Way B.M. Putting feelings into words: affect labeling disrupts amygdala activity in response to affective stimuli. Psychological Science 2007, 18:421-428.
23. Lochner C., Fouché J.-P., Plessis S., Spottiswoode B., Seedat S., Fineberg N., Chamberlain S.R., Stein D.J. Evidence for fractional anisotropy and mean diffusivity white matter abnormalities in the internal capsule and cingulum in patients with obsessive-compulsive disorder. Journal of Psychiatry and Neuroscience 2012, 37(3):193-199.
24. Mahmutyazicioğlu K., Konuk N., Özdemir H., Atasoy N., Atik L., Gündoğdu S. Evaluation of the hippocampus and the anterior cingulate gyrus by proton MR spectroscopy in patients with post-traumatic stress disorder. Diagnostic and Interventional Radiology 2005, 11:125-129.
25. Miller B.L. A review of chemical issues in 1H NMR spectroscopy: N-acetyl-l-aspartate, creatine and choline. NMR in Biomedicine 1991, 4:47-52.
26. Modi S., Trivedi R., Singh K., Kumar P., Rathore R.K.S., Tripathi R.P., Khushu S. Individual differences in trait anxiety are associated with white matter tract integrity in fornix and uncinate fasciculus: preliminary evidence from a DTI based tractography study. Behavioural Brain Research 2013, 238:188-192.
27. Montag C., Reuter M., Weber B., Marketta S., Schoene-bake J-C. Individual differences in trait anxiety are associated with white matter tract integrity in the left temporal lobe in healthy males but not females. Neuroscience 2012, 217:77-83.
28. Phan K.L., Fitzgerald D.A., Cortese B.M., Seraji-Bozorgzad N., Tancer M.E., Moore G.J. Anterior cingulate neurochemistry in social anxiety disorder: 1H-MRS at 4Tesla. Neuroreport 2004, 16(2):183-186.
29. Provencher S.W. Estimation of metabolite concentrations from localized in vivo NMR spectra. Magnetic Resonanace in Medicine 1993, 30:672-679.
30. Pujol J., Lodpez A., Deus J., Cardoner N., Vallejo J., Capdevila A., Paus T. Anatomical variability of the anterior cingulate gyrus and basic dimensions of human personality. NeuroImage 2002, 15:847-855.
31. Sala M., Perez J., Soloff P., Ucelli di Nemi S., Caverzasi E., Soares J.C., Brambilla P. Stress and hippocampal abnormalities in psychiatric disorders. European Neuropsychopharmacology 2004, 14(5):393-405.
32. Sandi C., Richter-Levin G. From high anxiety trait to depression: a neurocognitive hypothesis. Trends in Neuroscience 2009, 32(6):312-320.
33. Spielberger C.D. Manual for the State-Trait Anxiety Inventory 1983, Consulting Psychologists Press, Palo Alto, CA.
34. Strawn J.R., Chu W.J., Whitsel R.M., Weber W.A., Norris M.M., Adler C.M., Eliassen J.C., Phan K.L., Strakowski S.M., DelBello M.P. A pilot study of anterior cingulate cortex neurochemistry in adolescents with generalized anxiety disorder. Neuropsychobiology 2013, 67(4):224-229.
35. van Tol M.J., van der Wee N.J., van den Heuvel O.A., Nielen M.M., Demenescu L.R., Aleman A., Renken R., van Buchem M.A., Zitman F.G., Veltman D.J. Regional brain volume in depression and anxiety disorders. Archives of General Psychiatry 2010, 67(10):1002-1011.
36. Walker D.L., Davis M. The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction. Pharmacology, Biochemistry and Behavior 2002, 71:379-392.
37. Westlye L.T., Bjørnebekk A., Grydeland H., Fjell A.M., Walhovd K.B. Linking an anxiety-related personality trait to brain white matter microstructure diffusion tensor imaging and harm avoidance. Archives of General Psychiatry 2011, 68(4):369-377.
38. Whiteside S.P., Port J.D., Deacon B.J., Abramowitz J.S. A magnetic resonance spectroscopy investigation of obsessive-compulsive disorder and anxiety. Psychiatry Research: Neuroimaging 2006, 146:137-147.
39. Zhang Y., Filiou M.D., Reckow S., Gormanns P., Maccarrone G., Kessler M.S., Frank E., Hambsch B., Holsboer F., Landgraf R., Turck C.W. Proteomic and metabolomic profiling of a trait anxiety mouse model implicate affected pathways. Molecular & Cellular Proteomics 2011, 10:12.
40. Zwanzger P., Zavorotnyy M., Gencheva E., Diemer J., Kugel H., Heindel W., Ruland T., Ohrmann P., Arolt V., Domschke K., Pfleiderer B. Acute shift in glutamate concentrations following experimentally induced panic with cholecystokinin tetrapeptide-a 3T-MRS study in healthy subjects. Neuropsychopharmacology 2013, 38(9):1648-1654.