The progressive adaptation of a Georgian isolate of African swine fever virus to Vero cells leads to a gradual attenuation of virulence in swine corresponding to major modifications of the viral genome

Journal of Virology

Volumn 89, Issue 4, 2015, Pages 2324-2332

  Krug, Peter W ^a   Holinka, Lauren G ^a   O'Donnell, Vivian ^a,b   Reese, Bo ^b   Sanford, Brenton ^a   Fernandez Sainz, Ignacio ^a,b   Gladue, Douglas P ^a,b   Arzt, Jonathan ^a   Rodriguez, Luis ^a   Risatti, Guillermo R ^b   Borca, Manuel V ^a  

^a PLUM ISLAND ANIMAL DISEASE CENTER   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; AFRICAN SWINE FEVER; AFRICAN SWINE FEVER VIRUS; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DNA MODIFICATION; FRAMESHIFT MUTATION; GENE DELETION; GENOTYPE; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; NONHUMAN; PHENOTYPE; SEQUENCE ANALYSIS; SWINE; VERO CELL LINE; VIRUS ATTENUATION; VIRUS CULTURE; VIRUS GENE; VIRUS GENOME; VIRUS ISOLATION; VIRUS REPLICATION; VIRUS VIABILITY; VIRUS VIRULENCE; ANIMAL; CELL CULTURE; CHEMISTRY; CHLOROCEBUS AETHIOPS; DNA SEQUENCE; GENETICS; GEORGIA (REPUBLIC); GROWTH, DEVELOPMENT AND AGING; ISOLATION AND PURIFICATION; MUTATION; PHYSIOLOGY; PIG; VIRULENCE;

AFRICAN SWINE FEVER VIRUS; SUIDAE; SUS SCROFA DOMESTICA;

VIRUS DNA;

ADAPTATION, BIOLOGICAL; AFRICAN SWINE FEVER VIRUS; ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; DNA, VIRAL; GENOME, VIRAL; GENOTYPE; GEORGIA (REPUBLIC); MUTATION; PHENOTYPE; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION; SERIAL PASSAGE; SWINE; VIRULENCE;

EID: 84921671306     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.03250-14     Document Type: Article

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