Breaking the vicious cycle between breast cancer cells and tumor-associated macrophages

OncoImmunology

Volumn 3, Issue 8, 2014, Pages

  Su, Shicheng ^a   Wu, Wei ^a   He, Chonghua ^a   Liu, Qiang ^a   Song, Erwei ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

EMT; Humanized mice; Tumor metabolism; Tumor associated macrophages

Indexed keywords

CCL18 CHEMOKINE; CD14 ANTIGEN; CD19 ANTIGEN; CD34 ANTIGEN; CHEMOKINE; EPIDERMAL GROWTH FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTIC ACID; OXAMIC ACID; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER IMMUNOTHERAPY; CELL ACTIVATION; CELL METABOLISM; CYTOKINE PRODUCTION; DRUG EFFECT; EPITHELIAL MESENCHYMAL TRANSITION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNE EVASION; IMMUNOREGULATION; METABOLIC REGULATION; METASTASIS POTENTIAL; MOUSE MODEL; NOD SCID MOUSE; NONHUMAN; PHENOTYPE; POSITIVE FEEDBACK; SIGNAL TRANSDUCTION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT;

EID: 84921663148     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/21624011.2014.953418     Document Type: Article

References (10)

1. Su S, Liu Q, Chen J, Chen F, He C, Huang D, Wu W, Lin L, Huang W, Zhang J, et al. A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer Cell 2014; 25:605-20; PMID:24823638; http://dx.doi.org/10.1016/j.ccr.2014.03.021
2. Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 2006; 124:263-6; PMID:16439202; http://dx.doi.org/10.1016/j.cell.2006.01.007
3. Shultz LD, Brehm MA, Garcia-Martinez JV, Greiner DL. Humanized mice for immune system investigation: progress, promise and challenges. Nat Rev Immunol 2012; 12:786-98; PMID:23059428; http://dx.doi.org/10.1038/nri3311
4. Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 2009; 27:451-83; PMID:19105661; http://dx.doi.org/10.1146/annurev.immunol.021908.132532
5. Chen J, Yao Y, Gong C, Yu F, Su S, Liu B, Deng H, Wang F, Lin L, Yao H, et al. CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell 2011; 19:541-55; PMID:21481794; http://dx.doi.org/10.1016/j.ccr.2011.02.006
6. Marigo I, Bosio E, Solito S, Mesa C, Fernandez A, Dolcetti L, Ugel S, Sonda N, Bicciato S, Falisi E, et al. Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. Immunity 2010; 32:790-802; PMID:20605485; http://dx.doi.org/10.1016/j.immuni.2010.05.010
7. Filipazzi P, Valenti R, Huber V, Pilla L, Canese P, Iero M, Castelli C, Mariani L, Parmiani G, Rivoltini L. Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine. J Clin Oncol 2007; 25:2546-53; PMID:17577033; http://dx.doi.org/10.1200/JCO.2006.08.5829
8. Eggermont AM. Immunostimulation versus immunosuppression after multiple vaccinations: the woes of therapeutic vaccine development. Clin Cancer Res 2009; 15:6745-7; PMID:19903779; http://dx.doi.org/10.1158/1078-0432.CCR-09-2377
9. Hirschhaeuser F, Sattler UG, Mueller-Klieser W. Lactate: a metabolic key player in cancer. Cancer Res 2011; 71:6921-5; PMID:22084445; http://dx.doi.org/10.1158/0008-5472.CAN-11-1457
10. Cheong H, Lu C, Lindsten T, Thompson CB. Therapeutic targets in cancer cell metabolism and autophagy. Nat Biotechnol 2012; 30:671-8; PMID:22781696; http://dx.doi.org/10.1038/nbt.2285