MicroRNA-30d and microRNA-181a regulate HOXA11 expression in the uterosacral ligaments and are overexpressed in pelvic organ prolapse

Journal of Cellular and Molecular Medicine

Volumn 19, Issue 2, 2015, Pages 501-509

  Jeon, Myung Jae ^a   Kim, Eun Jae ^a   Lee, Maria ^a   Kim, Hoguen ^b   Choi, Jong Rak ^b   Chae, Hee Dong ^c   Moon, Yeo Jung ^b   Kim, Sei Kwang ^b   Bai, Sang Wook ^b  

^a Seoul National University College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

Author keywords

HOXA11; MicroRNA; Pelvic organ prolapse; Uterosacral ligament

Indexed keywords

HOMEODOMAIN PROTEIN; HOXA11 PROTEIN, HUMAN; MICRORNA; MIRN181 MICRORNA, HUMAN; MIRN30 MICRORNA, HUMAN;

CELL LINE; CONNECTIVE TISSUE; FEMALE; HEK293 CELL LINE; HUMAN; LIGAMENT; METABOLISM; MIDDLE AGED; PELVIC ORGAN PROLAPSE; UTERUS;

CELL LINE; CONNECTIVE TISSUE; FEMALE; HEK293 CELLS; HOMEODOMAIN PROTEINS; HUMANS; LIGAMENTS; MICRORNAS; MIDDLE AGED; PELVIC ORGAN PROLAPSE; UTERUS;

EID: 84921647799     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12448     Document Type: Article

References (33)

1. Jelovsek JE, Maher C, Barber MD. Pelvic organ prolapse. Lancet. 2007; 369: 1027-38.
2. Samuelsson EC, Victor FT, Tibblin G, et al. Signs of genital prolapse in a Swedish population of women 20 to 59 years of age and possible related factors. Am J Obstet Gynecol. 1999; 180: 299-305.
3. Smith FJ, Holman CD, Moorin RE, et al. Lifetime risk of undergoing surgery for pelvic organ prolapse. Obstet Gynecol. 2010; 116: 1096-100.
4. Subak LL, Waetjen LE, van den Eeden S, et al. Cost of pelvic organ prolapse surgery in the United States. Obstet Gynecol. 2001; 98: 646-51.
5. Wu JM, Hundley AF, Fulton RG, et al. Forecasting the prevalence of pelvic floor disorders in U.S. Women: 2010 to 2050. Obstet Gynecol. 2009; 114: 1278-83.
6. Clark AL, Gregory T, Smith VJ, et al. Epidemiologic evaluation of reoperation for surgically treated pelvic organ prolapse and urinary incontinence. Am J Obstet Gynecol. 2003; 189: 1261-7.
7. Connell KA, Guess MK, Chen H, et al. HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse. J Clin Invest. 2008; 118: 1050-5.
8. Ma Y, Guess M, Datar A, et al. Knockdown of Hoxa11 in vivo in the uterosacral ligament and uterus of mice results in altered collagen and matrix metalloproteinase activity. Biol Reprod. 2012; 86: 100.
9. Connell KA, Guess MK, Chen HW, et al. HOXA11 promotes fibroblast proliferation and regulates p53 in uterosacral ligaments. Reprod Sci. 2009; 16: 694-700.
10. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116: 281-97.
11. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005; 120: 15-20.
12. Kim VN. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol. 2005; 6: 376-85.
13. Iorio MV, Croce CM. MicroRNAs in cancer: small molecules with a huge impact. J Clin Oncol. 2009; 27: 5848-56.
14. Meola N, Gennarino VA, Banfi S. microRNAs and genetic diseases. Pathogenetics. 2009; 2: 7.
15. Mallo M, Alonso CR. The regulation of Hox gene expression during animal development. Development. 2013; 140: 3951-63.
16. Duisters RF, Tijsen AJ, Schroen B, et al. miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. Circ Res. 2009; 104: 170-8.
17. Sethupathy P, Megraw M, Hatzigeorgiou AG. A guide through present computational approaches for the identification of mammalian microRNA targets. Nat Methods. 2006; 3: 881-6.
18. Goh JT. Biomechanical and biochemical assessments for pelvic organ prolapse. Curr Opin Obstet Gynecol. 2003; 15: 391-4.
19. Jackson SR, Avery NC, Tarlton JF, et al. Changes in metabolism of collagen in genitourinary prolapse. Lancet. 1996; 347: 1658-61.
20. Gabriel B, Watermann D, Hancke K, et al. Increased expression of matrix metalloproteinase 2 in uterosacral ligaments is associated with pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct. 2006; 17: 478-82.
21. Strinic T, Vulic M, Tomic S, et al. Matrix metalloproteinases-1, -2 expression in uterosacral ligaments from women with pelvic organ prolapse. Maturitas. 2009; 64: 132-5.
22. Taylor H, Vanden Heuvel G, Igarashi P. A conserved hox axis in the mouse and human reproductive system: late establishment and persistent expression of the hoxa cluster genes. Biol Reprod. 1997; 57: 1338-45.
23. Wu C, Jin B, Chen L, et al. MiR-30d induces apoptosis and is regulated by the Akt/FOXO pathway in renal cell carcinoma. Cell Signal. 2013; 25: 1212-21.
24. Neilson JR, Zheng GX, Burge CB, et al. Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev. 2007; 21: 578-89.
25. Quyang YB, Lu Y, Yue S, et al. miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes. Mitochondrion. 2012; 12: 213-9.
26. Kim EJ, Chung N, Park SH, et al. Involvement of oxidative stress and mitochondrial apoptosis in the pathogenesis of pelvic organ prolapse. J Urol. 2013; 189: 588-94.
27. Wen Y, Ho JY, Polan ML, et al. Expression of apoptotic factors in vaginal tissues from women with urogenital prolapse. Neurourol Urodyn. 2011; 30: 1627-32.
28. Moalli PA, Klingensmith WL, Meyn LA, et al. Regulation of matrix metalloproteinase expression by estrogen in fibroblasts that are derived from the pelvic floor. Am J Obstet Gynecol. 2002; 187: 72-9.
29. Taylor HS, Igarashi P, Olive DL, et al. Sex steroids mediate HOXA11 expression in the human peri-implantation endometrium. J Clin Endocrinol Metab. 1999; 84: 1129-35.
30. Lang JH, Zhu L, Sun ZJ, et al. Estrogen levels and estrogen receptors in patients with stress urinary incontinence and pelvic organ prolapse. Int J Gynaecol Obstet. 2003; 80: 35-9.
31. Bai SW, Chung DJ, Yoon JM, et al. Roles of estrogen receptor, progesterone receptor, p53 and p21 in pathogenesis of pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct. 2005; 16: 492-6.
32. Zhao JJ, Lin J, Yang H, et al. MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer. J Biol Chem. 2008; 283: 31079-86.
33. Shi Z, Zhang T, Zhang L, et al. Increased microRNA-221/222 and decreased estrogen receptor α in the cervical portion of the uterosacral ligaments from women with pelvic organ prolapse. Int Urogynecol J. 2012; 23: 929-34.