Arterial stiffness in kidney transplantation: A single center case-control study comparing belatacept versus calcineurin inhibitor immunosuppressive based regimen

Nefrologia

Volumn 35, Issue 1, 2015, Pages 58-65

  Melilli, Edoardo ^a   Bestard Matamoros, Oriol ^a   Manonelles Montero, Anna ^a   Sala Bassa, Neus ^a   Mast, Richard ^a   Grinyó Boira, Josep M ^a   Cruzado, Josep M ^a  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

Arterial stiffness; Belatacept; Calcineurin inhibitors; Pulse wave velocity; Renal transplantation

Indexed keywords

ABATACEPT; CALCINEURIN INHIBITOR; IMMUNOSUPPRESSIVE AGENT;

ADULT; AGED; AORTA; ARTERIAL STIFFNESS; CASE CONTROL STUDY; CLINICAL TRIAL; COMPARATIVE STUDY; DRUG EFFECTS; FEMALE; FOLLOW UP; GRAFT VS HOST DISEASE; HUMAN; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PULSE WAVE; RISK FACTOR;

ABATACEPT; ADULT; AGED; AORTA; CALCINEURIN INHIBITORS; CASE-CONTROL STUDIES; FEMALE; FOLLOW-UP STUDIES; GRAFT VS HOST DISEASE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PULSE WAVE ANALYSIS; RISK FACTORS; VASCULAR STIFFNESS;

EID: 84921634429     PISSN: 02116995     EISSN: None     Source Type: Journal    
DOI: 10.3265/Nefrologia.pre2014.Sep.12615     Document Type: Article

References (33)

1. Pilmore H, Dent H, Chang S, McDonald SP, Chadban SJ. Reduction in cardiovascular death after kidney transplantation. Transplantation 2010;89:851-7.
2. Briet M, Boutouyrie P, Laurent S, London GM. Arterial stiffness and pulse pressure in CKD and ESRD. Kidney Int 2012;82:388-400.
3. Guerin AP, Blacher J, Pannier B, Marchais SJ, Safar ME, London GM. Impact of aortic stiffness attenuation on survival of patients in endstage renal disease. Circulation 2001;103:987-92.
4. Verbeke F, Maréchal C, Van Laecke S, Van Biesen W, Devuyst O, Van Bortel LM, et al. Aortic stiffness and central wave reflections predict outcome in renal transplant recipients. Hypertension 2011;58:833-8
5. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001;37:1236-41.
6. Kusche-Vihrog K, Urbanova K, Blanqué A, Wilhelmi M, Schillers H, Kliche K, et al. C-reactive protein makes human endothelium stiff and tight. Hypertension 2011;57(2):231-7.
7. Barnes JN, Nualnim N, Sugawara J, Sommerlad SM, Renzi CP, Tanaka H. Arterial stiffening, wave reflection, and inflammation in habitually exercising systemic lupus erythematosus patients. Am J Hypertens 2011;24(11):1194-200.
8. Temmar M, Liabeuf S, Renard C, Czernichow S, Esper NE, Shahapuni I, et al. Pulse wave velocity and vascular calcification at different stages of chronic kidney disease. J Hypertens 2010;28(1):163-9.
9. Cecelja M, Jiang B, Bevan L, Frost ML, Spector TD, Chowienczyk PJ. Arterial stiffening relates to arterial calcification but not to noncalcified atheroma in women. A twin study. J Am Coll Cardiol 2011;57(13):1480-6.
10. McEniery CM, Spratt M, Munnery M, Yarnell J, Lowe GD, Rumley A, et al. An analysis of prospective risk factors for aortic stiffness in men: 20-year follow-up from the Caerphilly prospective study. Hypertension 2010;56(1):36-43.
11. Bachelet-Rousseau C, Kearney-Schwartz A, Frimat L, Fay R, Kessler M, Benetos A. Evolution of arterial stiffness after kidney transplantation. Nephrol Dial Transplant 2011;26:3386-91.
12. Roullet JB, Xue H, McCarron DA, Holcomb S, Bennett WM. Vascular mechanisms of cyclosporin-induced hypertension in the rat. J Clin Invest 1994;93(5):2244-50.
13. Ha E, Mun KC. Effects of cyclosporine on metalloproteinase in endothelial cells. Transplant Proc 2012;44(4):991-2.
14. Seibert F, Behrendt C, Schmidt S, van der Giet M, Zidek W, Westhoff TH. Differential effects of cyclosporine and tacrolimus on arterial function. Transpl Int 2011;24:708-15.
15. Strózecki P, Adamowicz A, Włodarczyk Z, Manitius J. The influence of calcineuin inhibitors on pulse wave velocity in renal trasplant recipients. Ren Fail 2007;29(6):679-84.
16. Martínez-Castelao A, Sarrias X, Bestard O, Gil-Vernet S, Serón D, Cruzado JM, et al. Arterial elasticity measurement in renal transplant patients under anticalcineurin immunosuppression. Transplantation Proceedings 2005;37:3788-90.
17. Ma KL, Varghese Z, Ku Y, Powis SH, Chen Y, Moorhead JF, et al. Sirolimus inhibits endogenous cholesterol synthesis induced by inflammatory stress in human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 2010;298:H1646-51.
18. Hester J, Schiopu A, Nadig SN, Wood KJ. Low-dose rapamycin treatment increases the ability of human regulatory t cells to inhibit transplant arteriosclerosis in vivo. Am J Transplant 2012;12:2008-16.
19. Hiemann NE, Wellnhofer E, Lehmkuhl HB, Knosalla C, Hetzer R, Meyer R. Everolimus prevents endomyocardial remodeling after heart transplantation. Transplantation 2011;92(10):1165-72.
20. Joannidès R, Monteil C, de Ligny BH, Westeel PF, Iacob M, Thervet E, et al. Immunosuppressant regimen based on sirolimus decreases aortic stiffness in renal transplant recipients in comparison to cyclosporine. Am J Transplant 2011;11:2414-22.
21. Van Laecke S, Maréchal C, Verbeke F, Peeters P, Van Biesen W, Devuyst O, et al. The relation between hypomagnesaemia and vascular stiffness in renal transplant recipients. Nephrol Dial Transplant 2011;26:2362-9.
22. Gungor O, Kircelli F, Carrero JJ, Hur E, Demirci MS, Asci G, et al. The effect of immunosuppressive treatment on arterial stiffness and matrix Gla protein levels in renal transplant recipients. Clin Nephrol 2011;75:491-6.
23. Williams B, Lacy PS, Thom SM, Cruickshank K, Stanton A, Collier D, et al. Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation 2006;113(9):1213-25.
24. Agarwal R. Antihypertensive agents and arterial stiffness: relevance to reducing cardiovascular risk in the chronic kidney disease patient. Curr Opin Nephrol Hypertens 2007;16:409-15.
25. Vincenti F, Larsen CP, Alberu J, Bresnahan B, Garcia VD, Kothari J, et al. Three-year outcomes from BENEFIT, a randomized, activecontrolled, parallel-group study in adult kidney transplant recipients. Am J Transplant 2012;12:210-21.
26. Durrbach A, Pestana JM, Pearson T, Vincenti F, Garcia VD, Campistol J, et al. A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study). Am J Transplant 2010;10:547-57.
27. Larsen C, Grinyó J, Medina-Pestana J, Vanrenterghem Y, Vincenti F, Breshahan B, et al. Belatacept-based regimens versus a cyclosporine A-based regimen in kidney transplant recipients: 2-year results from the BENEFIT and BENEFIT-EXT studies. Transplantation 2010;90(12):1528-35.
28. Reference Values for Arterial Stiffness' Collaboration. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: 'establishing normal and reference values'. Eur Heart J 2010;31:2338-50.
29. Vinh A, Chen W, Blinder Y, Weiss D, Taylor WR, Goronzy JJ, et al. Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension. Circulation 2010;122:2529-37.
30. Kaess BM, Rong J, Larson MG, Hamburg NM, Vita JA, Levy D, et al. Aortic stiffness, blood pressure progression, and incident hypertension. JAMA 2012;308(9):875-81.
31. Claes K, Meyer-Kriesche HU, Schold JD, Vanrenterghem Y, Halloran PF, Ekberg H. Effect of different immunosuppressive regimens on the evolution of distinct metabolic parameters: evidence from the Simphony study. Nephrol Dial Transplant 2012;27:850-7.
32. Sjöblom P, Nystrom FH, Länne T, Engvall J, Östgren CJ. Microalbuminuria, but not reduced eGFR, is associated with cardiovascular subclinical organ damage in type 2 diabetes. Diabetes Metab 2014;40(1):49-55.
33. Hashimoto J, Ito S. Central pulse pressure and aortic stiffness determine renal hemodynamics: pathophysiological implication for microalbuminuria in hypertension. Hypertension 2011;58(5):839-46.