Identifying pathways leading to prefrontal GABA-ergic interneuron dysfunction in schizophrenia

American Journal of Psychiatry

Volumn 171, Issue 9, 2014, Pages 906-909

  Sohal, Vikaas S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ANTIDEPRESSANT AGENT; BENZODIAZEPINE DERIVATIVE; GLUTAMATE DECARBOXYLASE 67; MESSENGER RNA; NEU DIFFERENTIATION FACTOR; NEUROLEPTIC AGENT; NICOTINE; PARVALBUMIN; VALPROIC ACID; 4 AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; NRG1 PROTEIN, HUMAN;

ALLELE; BINDING SITE; BRAIN DYSFUNCTION; EDITORIAL; GENE; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; INTERNEURON; LASER MICRODISSECTION; MICROARRAY ANALYSIS; NEUROTRANSMISSION; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PHENOTYPE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SUBSTANCE USE; SUICIDE; ZIF268 GENE; ANIMAL; BIOSYNTHESIS; COGNITIVE DEFECT; FEMALE; GENETICS; MALE; NERVOUS SYSTEM DEVELOPMENT;

ANIMALS; ANTIPSYCHOTIC AGENTS; COGNITION DISORDERS; FEMALE; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; HUMANS; MALE; NEUREGULIN-1; NEUROGENESIS; PREFRONTAL CORTEX; SCHIZOPHRENIA;

EID: 84921628677     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2014.14060750     Document Type: Editorial

References (17)

1. Green MF: Cognitive impairment and functional outcome in schizophrenia and bipolar disorder. J Clin Psychiatry 2006; 67:e12
2. Minzenberg MJ, Carter CS: Developing treatments for impaired cognition in schizophrenia. Trends Cogn Sci 2012; 16:35-42
3. Minzenberg MJ, Laird AR, Thelen S, Carter CS, Glahn DC: Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia. Arch Gen Psychiatry 2009; 66:811-822
4. Lewis DA, Hashimoto T, Volk DW: Cortical inhibitory neurons and schizophrenia. Nat Rev Neurosci 2005; 6:312-324 (Pubitemid 40469985)
5. Benes FM, Berretta S: GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder. Neuropsychopharmacology 2001; 25:1-27 (Pubitemid 32493819)
6. Kimoto S, Bazmi HH, Lewis DA: Lower expression of glutamic acid decarboxylase 67 in the prefrontal cortex in schizophrenia: contribution of altered regulation by Zif268. Am J Psychiatry 2014; 171:969-978
7. Szabó G, Katarova Z, Körtvély E, Greenspan RJ, Urbán Z: Structure and the promoter region of the mouse gene encoding the 67-kD form of glutamic acid decarboxylase. DNA Cell Biol 1996; 15:1081-1091
8. Yanagawa Y, Kobayashi T, Kamei T, Ishii K, Nishijima M, Takaku A, Tamura S: Structure and alternative promoters of the mouse glutamic acid decarboxylase 67 gene. Biochem J 1997; 326:573-578 (Pubitemid 27417239)
9. Luo Y, Lathia J, Mughal M, Mattson MP: SDF1alpha/CXCR4 signaling, via ERKs and the transcription factor Egr1, induces expression of a 67-kDa form of glutamic acid decarboxylase in embryonic hippocampal neurons. J Biol Chem 2008; 283:24789-24800
10. Georgiev D, Arion D, Enwright JF, Kikuchi M, Minabe Y, Corradi JP, Lewis DA, Hashimoto T: Lower gene expression for KCNS3 potassium channel subunit in parvalbumin-containing neurons in the prefrontal cortex in schizophrenia. Am J Psychiatry 2014; 171:62- 71
11. Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI: Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature 2009; 459:663-667
12. Sohal VS, Zhang F, Yizhar O, Deisseroth K: Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature 2009; 459:698-702
13. Uhlhaas PJ, Singer W: Abnormal neural oscillations and synchrony in schizophrenia. Nat Rev Neurosci 2010; 11:100-113
14. Paterson C, Wang Y, Kleinman JE, Law AJ: Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development. Am J Psychiatry 2014; 171:979-989
15. Del Pino I, García-Frigola C, Dehorter N, Brotons-Mas JR, Alvarez-Salvado E, Martínez de Lagrán M, Ciceri G, Gabaldón MV, Moratal D, Dierssen M, Canals S, Marín O, Rico B: Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes. Neuron 2013; 79:1152-1168
16. Belforte JE, Zsiros V, Sklar ER, Jiang Z, Yu G, Li Y, Quinlan EM, Nakazawa K: Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes. Nat Neurosci 2010; 13:76-83
17. Behrens MM, Ali SS, Dao DN, Lucero J, Shekhtman G, Quick KL, Dugan LL: Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase. Science 2007; 318:1645-1647 (Pubitemid 350233667)