Enhanced generation of cord blood hematopoietic stem and progenitor cells by culture with StemRegenin1 and Delta1Ext-IgG

Leukemia

Volumn 28, Issue 10, 2014, Pages 2097-2101

  Dahlberg, A ^a,b   Brashem Stein, C ^a   Delaney, C ^a,b   Bernstein, I D ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CULTURE MEDIUM; CYTOKINE; DELTA1(EXT-IGG), HUMAN; HLA ANTIGEN; IMMUNOGLOBULIN G; NOTCH RECEPTOR; PURINE DERIVATIVE; STEMREGENIN 1;

CELL CULTURE; CELL PROLIFERATION; CHEMISTRY; CULTURE MEDIUM; CULTURE TECHNIQUE; CYTOLOGY; FETUS BLOOD; HEMATOPOIETIC STEM CELL; HUMAN; METABOLISM;

ANTIGENS, CD34; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELLS, CULTURED; CULTURE MEDIA; CYTOKINES; FETAL BLOOD; HEMATOPOIETIC STEM CELLS; HLA ANTIGENS; HUMANS; IMMUNOGLOBULIN G; PURINES; RECEPTORS, NOTCH;

EID: 84921522288     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2014.181     Document Type: Letter

References (15)

1. Canner J, Alonzo TA, Franklin J, Freyer DR, Gamis A, Gerbing RB et al. Differences in outcomes of newly diagnosed acute myeloid leukemia for adolescent/young adult and younger patients: a report from the Children’s Oncology Group. Cancer 2013; 119: 4162–4169. DOI: 10.1002/cncr.28342
2. Brunstein CG, Gutman JA, Weisdorf DJ, Woolfrey AE, Defor TE, Gooley TA et al. Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood. Blood 2010; 116: 4693–4699. DOI: 10.1182/blood-2010-05-285304
3. Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 2010; 329: 1345–1348. DOI: 10.1126/science.1191536
4. Dahlberg A, Delaney C, Bernstein ID. Ex vivo expansion of human hematopoietic stem and progenitor cells. Blood 2011; 117: 6083–6090. DOI: 10.1182/blood-2011-01-283606
5. Delaney C, Heimfeld S, Brashem-Stein C, Voorhies H, Manger RL, Bernstein ID. Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med 2010; 16: 232–236. DOI: 10.1038/nm.2080
6. de Lima M, McMannis J, Gee A, Komanduri K, Couriel D, Andersson BS et al. Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial. Bone Marrow Transplant 2008; 41: 771–778. DOI: 10.1038/sj.bmt.1705979
7. de Lima MR, McNiece I, Robinson SN, Munsell M, Eapen M, Horowitz M et al. Cord blood engraftment with ex vivo mesenchymal-cell coculture. N Engl J Med 2012; 367: 2305–2315. DOI: 10.1056/NEJMoa1207285
8. Horowitz M, Stiff PJ, Chao NJ, Rizzieri D, Long G, Sullivan K et al. Nicord® expanded hematopoietic progenitor cells (HPC) are capable of outcompeting the unmanipulated (UM) cord blood unit and of prolonged myeloid and lymphoid engraftment following myeloablative dual umbilical cord blood (UCB) transplantation. Biol Blood Marrow Transplant 2013; 19: Abstract 18.
9. Wagner JE, Brunstein CG, McKenna D, Sumstad D, Maahs S, Boitano AE et al. Safety and exploratory efficacy of ex-vivo expanded umbilical cord blood (UCB) hematopoietic stem and progenitor cells (HSPC) using cytokines and Stem-Regenin 1 (SR1): Interim results of a phase 1/2 dose escalation clinical study. Blood 2013; 122: Abstract 698.
10. Sang L, Coller HA, Roberts JM. Control of the reversibility of cellular quiescence by the transcriptional repressor HES1. Science 2008; 321: 1095–1100. DOI: 10.1126/science.1155998
11. Majeti R, Park CY, Weissman IL. Identification of a hierarchy of multipotent progenitors in human cord blood. Cell Stem Cell 2007; 1: 635–645. DOI: 10.1016/j.stem.2007.10.001
12. Manz MG, Miyamoto T, Akashi K, Weissman IL. Prospective isolation of human clonogenic common myeloid progenitors. Proc Natl Acad Sci USA 2002; 99: 11872–11877. DOI: 10.1073/pnas.172384399
13. Thomsen JS, Kietz S, Ström A, Gustafsson J. HES-1, a novel target gene for the aryl hydrocarbon receptor. Mol Pharmacol 2004; 65: 165–171. DOI: 10.1124/mol.65.1.165
14. Kunisato A, Chiba S, Nakagami-Yamaguchi E, Kumano K, Saito T, Masuda S et al. HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo. Blood 2003; 101: 1777–1783. DOI: 10.1182/blood-2002-07-2051
15. Singh KP, Garrett RW, Casado FL, Gasiewicz TA. Aryl hydrocarbon-receptor null allele mice have hematopoietic stem/progenitor cells with abnormal characteristics and functions. Stem Cells Dev 2011; 20: 769–784. DOI: 10.1089/scd.2010.0333