Cutting edge: Progesterone directly upregulates vitamin D receptor gene expression for efficient regulation of T cells by calcitriol

Journal of Immunology

Volumn 194, Issue 3, 2015, Pages 883-886

  Thangamani, Shankar ^a   Kim, Myughoo ^a   Son, Youngmin ^a   Huang, Xinxin ^b   Kim, Heejoo ^a   Lee, Jee H ^a   Cho, Jungyoon ^a   Ulrich, Benjamin ^a   Broxmeyer, Hal E ^b   Kim, Chang H ^a,b,c,d  

^a PURDUE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PURDUE UNIVERSITY   (United States)

^d Purdue University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; MESSENGER RNA; PROGESTERONE; PROGESTERONE RECEPTOR; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; PROTEIN BINDING;

ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; EFFECTOR CELL; EXON; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; RECEPTOR BINDING; REGULATORY T LYMPHOCYTE; SENSITIVITY ANALYSIS; TH1 CELL; TH17 CELL; UPREGULATION; VDR GENE; ANIMAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FEMALE; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; VITAMIN D RESPONSIVE ELEMENT;

ANIMALS; BASE SEQUENCE; CALCITRIOL; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PROGESTERONE; PROTEIN BINDING; RECEPTORS, CALCITRIOL; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY; VITAMIN D RESPONSE ELEMENT;

EID: 84921494821     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401923     Document Type: Article

References (28)

1. Henry, H. L. 2011. Regulation of vitamin D metabolism. Best Pract. Res. Clin. Endocrinol. Metab. 25: 531-541.
2. Cantorna, M. T. 2011. Why do T cells express the vitamin D receptor? Ann. N. Y. Acad. Sci. 1217: 77-82.
3. + T cells. Eur. J. Immunol. 42: 2697-2708.
4. 3 promotes FOXP3 expression via binding to vitamin D response elements in its conserved noncoding sequence region. J. Immunol. 188: 5276-5282.
5. 3 ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol. Cell. Biol. 31: 3653-3669.
6. Ghoreishi, M., P. Bach, J. Obst, M. Komba, J. C. Fleet, and J. P. Dutz. 2009. Expansion of antigen-specific regulatory T cells with the topical vitamin D analog calcipotriol. J. Immunol. 182: 6071-6078.
7. 3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis. Eur. J. Immunol. 41: 822-832.
8. Chang, S. H., Y. Chung, and C. Dong. 2010. Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression. J. Biol. Chem. 285: 38751-38755.
9. 3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo. Proc. Natl. Acad. Sci. USA 98: 6800-6805.
10. 3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells. J. Immunol. 178: 145-153.
11. Spencer, T. E., and F. W. Bazer. 2002. Biology of progesterone action during pregnancy recognition and maintenance of pregnancy. Front. Biosci. 7: d1879-d1898.
12. DeLuca, H. F. 1988. The vitamin D story: a collaborative effort of basic science and clinical medicine. FASEB J. 2: 224-236.
13. Lee, J. H., B. Ulrich, J. Cho, J. Park, and C. H. Kim. 2011. Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells. J. Immunol. 187: 1778-1787.
14. + regulatory T cells. J. Immunol. 177: 840-851.
15. Chang, J., S. Thangamani, M. H. Kim, B. Ulrich, S. M. Morris, Jr., and C. H. Kim. 2013. Retinoic acid promotes the development of Arg1-expressing dendritic cells for the regulation of T-cell differentiation. Eur. J. Immunol. 43: 967-978.
16. Kommagani, R., T. M. Caserta, and M. P. Kadakia. 2006. Identification of vitamin D receptor as a target of p63. Oncogene 25: 3745-3751.
17. Chiron Diagnostics ACS. 1998. Centaur Progesterone Assay Manual. Chiron Diagnostics, Emmeryville, CA.
18. 3 in the immune system. J. Steroid Biochem. Mol. Biol. 121: 221-227.
19. 3: a transcriptional modulator of the interferon-γ gene. Eur. J. Immunol. 28: 3017-3030.
20. + regulatory T cells allows for their purification from expansion cultures. Blood 113: 5125-5133.
21. + T cells identifies mucosally differentiated cells in protein fed mice and in human celiac disease patients and controls. Am. J. Gastroenterol. 106: 1147-1159.
22. Zella, L. A., M. B. Meyer, R. D. Nerenz, S. M. Lee, M. L. Martowicz, and J. W. Pike. 2010. Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription. Mol. Endocrinol. 24: 128-147.
23. von Essen, M. R., M. Kongsbak, P. Schjerling, K. Olgaard, N. Odum, and C. Geisler. 2010. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat. Immunol. 11: 344-349.
24. Looker, A. C., C. M. Pfeiffer, D. A. Lacher, R. L. Schleicher, M. F. Picciano, and E. A. Yetley. 2008. Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. Am. J. Clin. Nutr. 88: 1519-1527.
25. Bodnar, L. M., J. M. Catov, H. N. Simhan, M. F. Holick, R. W. Powers, and J. M. Roberts. 2007. Maternal vitamin D deficiency increases the risk of preeclampsia. J. Clin. Endocrinol. Metab. 92: 3517-3522.
26. Møller, U. K., S. Streym, L. Heickendorff, L. Mosekilde, and L. Rejnmark. 2012. Effects of 25OHD concentrations on chances of pregnancy and pregnancy outcomes: a cohort study in healthy Danish women. Eur. J. Clin. Nutr. 66: 862-868.
27. Dror, D. K. 2011. Vitamin D status during pregnancy: maternal, fetal, and postnatal outcomes. Curr. Opin. Obstet. Gynecol. 23: 422-426.
28. Lee, L. R., P. N. Teng, H. Nguyen, B. L. Hood, L. Kavandi, G. Wang, J. M. Turbov, L. G. Thaete, C. A. Hamilton, G. L. Maxwell, et al. 2013. Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells. Cancer Prev. Res. (Phila.) 6: 731-743.