TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis

Journal of Immunology

Volumn 194, Issue 3, 2015, Pages 1169-1177

  Cuenca, Alex G ^a   Joiner, Dallas N ^a   Gentile, Lori F ^a   Cuenca, Angela L ^a   Wynn, James L ^b   Kelly Scumpia, Kindra M ^a   Scumpia, Philip O ^a   Behrns, Kevin E ^a   Efron, Philip A ^a   Nacionales, Dina ^a   Lui, Chao ^a   Wallet, Shannon M ^a   Reeves, Westley H ^a   Mathews, Clayton E ^a   Moldawer, Lyle L ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; KERATINOCYTE GROWTH FACTOR; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA; CHEMOKINE; CYTOKINE; INTERFERON; TICAM-1 PROTEIN, MOUSE; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; BACTERIAL PERITONITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; ESCHERICHIA COLI; FEMALE; GRAM NEGATIVE SEPSIS; IMMUNE RESPONSE; IMMUNOMODULATION; INFECTION SENSITIVITY; INNATE IMMUNE ACTIVATION; INNATE IMMUNITY; LEUKOCYTE MIGRATION; MACROPHAGE; MALE; NEUTROPHIL; NEWBORN; NEWBORN MORTALITY; NONHUMAN; ONSET AGE; PHAGOCYTOSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SURVIVAL RATE; YOUNG ADULT; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; DISEASE PREDISPOSITION; GENETIC PREDISPOSITION; GENETICS; GRAM NEGATIVE INFECTION; GRANULOCYTE; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; MORTALITY; MOUSE; PERITONEUM MACROPHAGE; SEPSIS;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ANIMALS, NEWBORN; CHEMOKINE CXCL10; CHEMOKINES; CYTOKINES; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; ESCHERICHIA COLI; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GRAM-NEGATIVE BACTERIAL INFECTIONS; GRANULOCYTES; IMMUNITY, INNATE; INTERFERON TYPE I; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, KNOCKOUT; NEUTROPHILS; PHAGOCYTOSIS; REACTIVE OXYGEN SPECIES; SEPSIS; TOLL-LIKE RECEPTORS;

EID: 84921492328     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1302676     Document Type: Article

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