Inflammatory cell burden and phenotype in endomyocardial biopsies with antibody-mediated rejection (AMR): A multicenter pilot study from the AECVP

American Journal of Transplantation

Volumn 15, Issue 2, 2015, Pages 526-534

  Fedrigo, M ^a   Leone, O ^b   Burke, M M ^c   Rice, A ^c   Toquet, C ^d   Vernerey, D ^e   Frigo, A C ^a   Guillemain, R ^e   Pattier, S ^d   Smith, J ^c   Lota, A ^c   Potena, L ^b   Bontadini, A ^b   Ceccarelli, C ^b   Poli, F ^f   Feltrin, G ^a   Gerosa, G ^a   Manzan, E ^a   Thiene, G ^a   Bruneval, P ^e   Angelini, A ^a   Van Huyen, J P Duong ^e   more..

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c HAREFIELD HOSPITAL   (United Kingdom)

^d CHU de Nantes   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f NIT Policlinico Mangiagalli Regina Elena   (Italy)

Author keywords

Biopsy; classification systems: ISHLT classification; clinical research; heart transplantation: cardiology; histopathology; macrophage; monocyte biology: activation; pathology; practice; rejection: antibody mediated (ABMR)

Indexed keywords

ACUTE GRAFT REJECTION; ADULT; ANTIBODY MEDIATED REJECTION; ARTICLE; CELL COUNTING; CONTROLLED STUDY; FEMALE; HEART GRAFT; HEART MUSCLE BIOPSY; HISTOPATHOLOGY; HUMAN; IMMUNOFLUORESCENCE; IMMUNOPHENOTYPING; INFLAMMATORY CELL; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MICROSCOPY; MONONUCLEAR CELL; PHENOTYPE; PILOT STUDY; PLASMA CELL; POPULATION RESEARCH; PRIORITY JOURNAL; T LYMPHOCYTE; BIOPSY; CAPILLARY; CASE CONTROL STUDY; CLINICAL TRIAL; DONOR; EUROPE; GRAFT REJECTION; HEART TRANSPLANTATION; IMMUNOLOGY; INCIDENCE; INFLAMMATION; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; MYOCARDITIS; PATHOLOGY; RETROSPECTIVE STUDY;

ANTIBODY; COMPLEMENT C4D; COMPLEMENT COMPONENT C4B; PEPTIDE FRAGMENT;

ADULT; ANTIBODIES; BIOPSY; CAPILLARIES; CASE-CONTROL STUDIES; COMPLEMENT C4B; EUROPE; FEMALE; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; INCIDENCE; INFLAMMATION; MALE; MIDDLE AGED; MYOCARDITIS; PEPTIDE FRAGMENTS; PHENOTYPE; PILOT PROJECTS; RETROSPECTIVE STUDIES; TISSUE DONORS;

EID: 84921492022     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12976     Document Type: Article

References (25)

1. Lones MA, Czer LS, Trento A, Harasty D, Miller JM, Fishbein MC., Clinical-pathologic features of humoral rejection in cardiac allografts: A study in 81 consecutive patients.J Heart Lung Transplant 1995; 14 (1 Pt 1): 151-162.
2. Fishbein GA, Fishbein MC., Morphologic and immunohistochemical findings in antibody-mediated rejection of the cardiac allograft.Hum Immunol 2012; 173: 1213-1217.
3. Behr TM, Feucht HE, Richter K, et al.Detection of humoral rejection in human cardiac allografts by assessing the capillary deposition of complement fragment C4d in endomyocardial biopsies.J Heart Lung Transplant 1999; 18: 904-912.
4. Fedrigo M, Gambino A, Tona F, et al.Can C4d immunostaining on endomyocardial biopsies be considered a prognostic biomarker in heart transplant recipients ? Transplantation 2010; 90: 791-798.
5. Valenzuela NM, Hong L, Shen XD, et al.Blockade of p-selectin is sufficient to reduce MHC I antibody-elicited monocyte recruitment in vitro and in vivo.Am J Transplant 2013; 13: 299-311.
6. Wu GW, Kobashigawa JA, Fishbein MC, et al.Asymptomatic antibody-mediated rejection after heart transplantation predicts poor outcomes.J Heart Lung Transplant 2009; 28: 417-422.
7. Berry GJ, Angelini A, Burke MM, et al.The ISHLT working formulation for pathologic diagnosis of antibody-mediated rejection in heart transplantation: Evolution and current status (2005-2011).J Heart Lung Transplant 2011; 30: 601-611.
8. Kobashigawa J, Crespo-Leiro MG, Ensminger SM, et al.Report from a consensus conference on antibody-mediated rejection in heart transplantation.J Heart Lung Transplant 2011; 30: 252-269.
9. Kfoury AG, Snow GL, Budge D, et al.A longitudinal study of the course of asymptomatic antibody-mediated rejection in heart transplantation.J Heart Lung Transplant 2012; 31: 46-51.
10. Berry GJ, Burke MM, Andersen C, et al.The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation.J Heart Lung Transplant 2013; 32: 1147-1162.
11. Fedrigo M, Leone O, Burke M, et al.Inflammatory cell burden and phenotype in endomyocardial biopsies from patients with antibody-mediated rejection (AMR)-An AECVP multicenter study.J Heart Lung Transplant 2013; 32: S19-S19.
12. Trpkov K, Campbell P, Pazderka F, Cockfield S, Solez K, Halloran PF., Pathologic features of acute renal allograft rejection associated with donor-specific antibody, Analysis using the Banff grading schema.Transplantation 1996; 61: 1586-1592.
13. Sis B, Jhangri GS, Riopel J, et al.A new diagnostic algorithm for antibody-mediated microcirculation inflammation in kidney transplants.Am J Transplant 2012; 12: 1168-1179.
14. Loupy A, Cazes A, Guillemain R, et al.Very late heart transplant rejection is associated with microvascular injury, complement deposition and progression to cardiac allograft vasculopathy.Am J Transplant 2011; 11: 1478-1487.
15. Tavora F, Munivenkatappa R, Papadimitriou J, et al.Endothelitis in cardiac allograft biopsy specimens: Possible relationship to antibody-mediated rejection.J Heart Lung Transplant 2011; 30: 435-444.
16. Hammond EH, Yowell RL, Nunoda S, et al.Vascular (humoral) rejection in heart transplantation: Pathologic observations and clinical implications.J Heart Transplant 1989; 8: 430-443.
17. Kfoury AG, Stehlik J, Renlund DG, et al.Impact of repetitive episodes of antibody-mediated or cellular rejection on cardiovascular mortality in cardiac transplant recipients: Defining rejection patterns.J Heart Lung Transplant 2006; 25: 1277-1282.
18. Stewart S, Winters GL, Fishbein MC, et al.Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection.J Heart Lung Transplant 2005; 24: 1710-1720.
19. Tible M, Loupy A, Vernerey D, et al.Pathologic classification of antibody-mediated rejection correlates with donor-specific antibodies and endothelial cell activation.J Heart Lung Transplant 2013; 32: 769-776.
20. Fedrigo M, Feltrin G, Poli F, et al.Intravascular macrophages in cardiac allograft biopsies for diagnosis of early and late antibody-mediated rejection.J Heart Lung Transplant 2013; 32: 404-409.
21. Sis B, Halloran PF., Endothelial transcripts uncover a previously unknown phenotype: C4d-negative antibody-mediated rejection.Curr Opin Organ Transplant 2010; 15: 42-48.
22. Gartner V, Eigentler TK, Viebahn R., Plasma cell-rich rejection processes in renal transplantation: Morphology and prognostic relevance.Transplantation 2006; 81: 986-991.
23. Meehan SM, Domer P, Josephson M, et al.The clinical and pathologic implications of plasmacytic infiltrates in percutaneous renal allograft biopsies.Hum Pathol 2001; 32: 205-215.
24. Einecke G, Sis B, Reeve J, et al.Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure.Am J Transplant 2009; 9: 2520-2531.
25. Chang A, Moore JM, Cowan ML, et al.Plasma cell densities and glomerular filtration rates predict renal allograft outcomes following acute rejection.Transpl Int 2012; 25: 1050-1058.