Schizophrenia

Encyclopedia of Behavioral Neuroscience

Volumn , Issue , 2010, Pages 188-195

  Ellenbroek, B A ^a  

^a Evotec Neurosciences   (Germany)

Author keywords

Animal model; Antipsychotic; Biomarkers; DISC I; Endophenotypes; Gene environment interaction; Isolation rearing; Maternal deprivation; Neuregulin; Neurodevelopmental hypothesis; Prenatal stress; Prepulse inhibition; Schizophrenia; Screening model; Simulation model

Indexed keywords

EID: 84921476012     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-08-045396-5.00019-1     Document Type: Chapter

References (12)

1. Arguello P.A., Gogos J.A. Modeling madness in mice: One piece at a time. Neuron 2006, 52:179-196.
2. Carpenter W.T., Koenig J.I. The evolution of drug development in schizophrenia: Past issues and future opportunities. Neuropsychopharmacology 2008, 33:2061-2079.
3. Conn P.J., Roth B.L. Opportunities and challenges of psychiatric drug discovery: Roles for scientists in academic, industry, and government settings. Neuropsychopharmacology 2008, 33:2048-2060.
4. Ellenbroek B.A. Treatment of schizophrenia: A clinical and preclinical evaluation of neuroleptic drugs. Pharmacology and Therapeutics 1993, 57:1-78.
5. Ellenbroek B.A., Cools A.R. Animal models for schizophrenia. Textbook of Biological Psychiatry 2002, 567-580. Wiley, Chichester. H. D'Haenen, J.A. den Boer, H. Westenberg, P. Willner (Eds.).
6. Geyer M.A., Krebs-Thomson K., Braff D.L., Swerdlow N.R. Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenic patients: A decade in review. Psychopharmacology 2001, 156:117-154.
7. Gray J.A., Roth B.L. The pipeline and future of drug development in schizophrenia. Molecular Psychiatry 2007, 12:904-922.
8. Harrison P.J., Weinberger D.R. Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence. Molecular Psychiatry 2005, 10:40-68.
9. O'Tuathaigh C.M.P., Babovic D., O'Meara G., Clifford J.J., Croke D.T., Waddington J.L. Susceptibility genes for schizophrenia: Characterisation of mutant mouse models at the level of phenotypic behaviour. Neuroscience and Biobehavioral Reviews 2007, 31:60-78.
10. Rapoport J.L., Addington A.M., Frangou S., Psych M. The neurodevelopmental model of schizophrenia: Update 2005. Molecular Psychiatry 2005, 10:434-449.
11. Swerdlow N.R., Weber M., Qu Y., Light G.A., Braff D.L. Realistic expectations of prepulse inhibition in translational models for schizophrenia research. Psychopharmacology 2008, 199:331-388.
12. Schizophrenia. http://www.schizophrenia.com.