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Angewandte Chemie - International Edition

Volumn 54, Issue 5, 2015, Pages 1578-1582

Multitarget drug discovery for Alzheimer's disease: Triazinones as BACE-1 and GSK-3β inhibitors

(19) Prati, Federica a,b De Simone, Angela a,b Bisignano, Paola a Armirotti, Andrea a Summa, Maria a Pizzirani, Daniela a Scarpelli, Rita a Perez, Daniel I c Andrisano, Vincenza b Perez Castillo, Ana d,e Monti, Barbara b Massenzio, Francesca b Polito, Letizia f Racchi, Marco g Favia, Angelo D a Bottegoni, Giovanni a Martinez, Ana c Bolognesi, Maria Laura b Cavalli, Andrea a,b

a ISTITUTO ITALIANO DI TECNOLOGIA (Italy)

b UNIVERSITY OF BOLOGNA (Italy)

c CENTRO DE INVESTIGACIONES BIOLÓGICAS (Spain)

d INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS (Spain)

e CIBERNED Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (Spain)

f Golgi Cenci Foundation (Italy)

g UNIVERSITY OF PAVIA (Italy)

Author keywords

Drug design; Drug discovery; Enzymes; Heterocycles; Neurochemistry

Indexed keywords

BIOCHEMISTRY; ENZYMES; LEAD COMPOUNDS;

ALZHEIMER'S DISEASE; CELL-BASED ASSAYS; CUMULATIVE EVIDENCE; DRUG DESIGN; DRUG DISCOVERY; HETEROCYCLES; NEUROCHEMISTRY; THERAPEUTIC STRATEGY;

NEURODEGENERATIVE DISEASES;

ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; PROTEIN BINDING; SECRETASE; TRIAZINE DERIVATIVE;

ALZHEIMER DISEASE; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD BRAIN BARRIER; CHEMISTRY; CYTOLOGY; DRUG DESIGN; DRUG EFFECTS; DRUG SCREENING; ENZYME ACTIVE SITE; HALF LIFE TIME; METABOLISM; MICROGLIA; MOLECULAR DOCKING; MOUSE; PATHOLOGY; RAT; UPREGULATION;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BLOOD-BRAIN BARRIER; CATALYTIC DOMAIN; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HALF-LIFE; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; MOLECULAR DOCKING SIMULATION; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN BINDING; RATS; TRIAZINES; UP-REGULATION;

EID: 84921474414 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201410456 Document Type: Article

Times cited : (116)

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