Mutations and microenvironment collude in FL

Blood

Volumn 125, Issue 4, 2015, Pages 587-589

  Neelapu, Sattva S ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND; INTERLEUKIN 4; STAT6 PROTEIN; STAT6 PROTEIN, HUMAN; TUMOR PROTEIN;

APOPTOSIS; ARTICLE; B CELL LYMPHOMA; CANCER PATIENT; CYTOKINE PRODUCTION; DNA BINDING; FOLLICULAR LYMPHOMA; GENE EXPRESSION PROFILING; GENE MUTATION; HELPER CELL; HUMAN; IMMUNE EVASION; IMMUNOFLUORESCENCE; IN VITRO STUDY; LARGE CELL LYMPHOMA; LUCIFERASE ASSAY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; STROMA CELL; TUMOR MICROENVIRONMENT; CELL NUCLEUS; GENE EXPRESSION REGULATION; METABOLISM; MISSENSE MUTATION;

CELL NUCLEUS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LYMPHOMA, FOLLICULAR; MUTATION, MISSENSE; NEOPLASM PROTEINS; STAT6 TRANSCRIPTION FACTOR;

EID: 84921470842     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-12-615294     Document Type: Article

References (10)

1. Yildiz M, Li H, Bernard D, et al. Activating STAT6 mutations in follicular lymphoma. Blood. 2015;125(4):668-679.
2. Schmitter D, Koss M, Niederer E, Stahel RA, Pichert G. T-cell derived cytokines co-stimulate proliferation of CD40-activated germinal centre as well as follicular lymphoma cells. Hematol Oncol. 1997;15(4):197-207.
3. Dave SS, Wright G, Tan B, et al. Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med. 2004; 351(21):2159-2169.
4. Green MR, Gentles AJ, Nair RV, et al. Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma. Blood. 2013;121(9): 1604-1611.
5. Pasqualucci L, Khiabanian H, Fangazio M, et al. Genetics of follicular lymphoma transformation. Cell Reports. 2014;6(1):130-140.
6. Okosun J, Bödör C, Wang J, et al. Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma. Nat Genet. 2014;46(2):176-181.
7. Calvo KR, Dabir B, Kovach A, et al. IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma. Blood. 2008;112(9):3818-3826.
8. Pangault C, Amé-Thomas P, Ruminy P, et al. Follicular lymphoma cell niche: identi fication of a preeminent IL-4-dependent T(FH)-B cell axis. Leukemia. 2010;24(12):2080-2089.
9. Rawal S, Chu F, ZhangM, et al. Cross talk between follicular Th cells and tumor cells in human follicular lymphoma promotes immune evasion in the tumor microenvironment. J Immunol. 2013;190(12): 6681-6693.
10. Ritz O, Guiter C, Castellano F, et al. Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma. Blood. 2009;114(6): 1236-1242.