A genetic marker of uric acid level, carotid atherosclerosis, and arterial stiffness: A family-based study

American Journal of Kidney Diseases

Volumn 65, Issue 2, 2015, Pages 294-302

  Mallamaci, Francesca ^a,b   Testa, Alessandra ^a   Leonardis, Daniela ^a   Tripepi, Rocco ^a   Pisano, Anna ^a   Spoto, Belinda ^a   Sanguedolce, Maria Cristina ^a   Parlongo, Rosa Maria ^a   Tripepi, Giovanni ^a   Zoccali, Carmine ^a,b  

^a BIANCHI MELACRINO MORELLI HOSPITAL   (Italy)

^b Ipertensione e Trapianto Renale Ospedali Riuniti   (Italy)

Author keywords

Atherosclerosis glucose; cardiovascular disease; hyperuricemia SLC2A9 rs734553; pulse wave velocity (PWV); transporter type 9 (GLUT9); uric acid intima media thickness (IMT)

Indexed keywords

BIOLOGICAL MARKER; URIC ACID; GENETIC MARKER; GLUCOSE TRANSPORTER; SLC2A9 PROTEIN, HUMAN;

ADULT; AGE DISTRIBUTION; ALLELE; ARTERIAL STIFFNESS; ARTERIAL WALL THICKNESS; ARTICLE; CAROTID ATHEROSCLEROSIS; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; FAMILY; FEMALE; GENETIC MARKER; HUMAN; HYPOTHESIS; ITALY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PULSE WAVE; RISK ASSESSMENT; URIC ACID BLOOD LEVEL; BLOOD; CAROTID ARTERY DISEASES; GENETIC POLYMORPHISM; GENETICS; HYPERURICEMIA; PHYSIOLOGY; RISK FACTOR; YOUNG ADULT;

ADULT; ALLELES; BIOLOGICAL MARKERS; CAROTID ARTERY DISEASES; CAROTID INTIMA-MEDIA THICKNESS; CROSS-SECTIONAL STUDIES; FEMALE; GENETIC MARKERS; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HUMANS; HYPERURICEMIA; ITALY; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RISK FACTORS; URIC ACID; VASCULAR STIFFNESS; YOUNG ADULT;

EID: 84921460480     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2014.07.021     Document Type: Article

References (51)

1. D.I. Feig, D.H. Kang, and R.J. Johnson Uric acid and cardiovascular risk N Engl J Med 359 2008 1811 1821
2. R.J. Johnson, L.G. Sanchez-Lozada, M. Mazzali, D.I. Feig, M. Kanbay, and Y.Y. Sautin What are the key arguments against uric acid as a true risk factor for hypertension? Hypertension 61 2013 948 951
3. R.J. Johnson, J. Herrera-Acosta, G.F. Schreiner, and B. Rodriguez-Iturbe Subtle acquired renal injury as a mechanism of salt-sensitive hypertension N Engl J Med 346 2002 913 923
4. D.I. Feig Hyperuricemia and hypertension Adv Chronic Kidney Dis 19 2012 377 385
5. Y. Zhu, B.J. Pandya, and H.K. Choi Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008 Arthritis Rheum 63 2011 3136 3141
6. G.D. Smith, and S. Ebrahim Mendelian randomization: prospects, potentials, and limitations Int J Epidemiol 33 2004 30 42
7. M.J. Caulfield, P.B. Munroe, and D. O'Neill SLC2A9 is a high-capacity urate transporter in humans PLoS Med 5 2008 e197
8. Q. Yang, A. Kottgen, and A. Dehghan Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors Circ Cardiovasc Genet 3 2010 523 530
9. A. Kottgen, E. Albrecht, and A. Teumer Genome-wide association analyses identify 18 new loci associated with serum urate concentrations Nat Genet 45 2013 145 154
10. B. Benyamin, P.M. Visscher, and A.F. McRae Family-based genome-wide association studies Pharmacogenomics 10 2009 181 190
11. H. Zhao Family-based association studies Stat Methods Med Res 9 2000 563 587
12. M. Kolz, T. Johnson, and S. Sanna Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations PLoS Genet 5 2009 e1000504
13. C. Di Gaetano, F. Voglino, and S. Guarrera An overview of the genetic structure within the Italian population from genome-wide data PLoS One 7 2012 e43759
14. H. Freisling, M.T. Fahey, and A. Moskal Region-specific nutrient intake patterns exhibit a geographical gradient within and between European countries J Nutr 140 2010 1280 1286
15. M.L. Eigenbrodt, Z. Bursac, and K.M. Rose Common carotid arterial interadventitial distance (diameter) as an indicator of the damaging effects of age and atherosclerosis, a cross-sectional study of the Atherosclerosis Risk in Community Cohort Limited Access Data (ARICLAD), 1987-89 Cardiovasc Ultrasound 2006 4:1
16. M. Castellano, N. Glorioso, and D. Cusi Genetic polymorphism of the renin-angiotensin-aldosterone system and arterial hypertension in the Italian population: the GENIPER Project J Hypertens 21 2003 1853 1860
17. F.A. Benedetto, F. Mallamaci, G. Tripepi, and C. Zoccali Prognostic value of ultrasonographic measurement of carotid intima media thickness in dialysis patients J Am Soc Nephrol 12 2001 2458 2464
18. I.B. Wilkinson, S.A. Fuchs, and I.M. Jansen Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis J Hypertens 16 pt 2 1998 2079 2084
19. A.S. Levey, T. Greene, J. Kusek, and G. Beck A simplified equation to predict glomerular filtration rate from serum creatinine [abstract] J Am Soc Nephrol 11 2000 155A
20. S. Killip, Z. Mahfoud, and K. Pearce What is an intracluster correlation coefficient? Crucial concepts for primary care researchers Ann Fam Med 2 2004 2004 2008
21. C. Bengtsson, L. Lapidus, C. Stendahl, and J. Waldenstrom Hyperuricaemia and risk of cardiovascular disease and overall death. A 12-year follow-up of participants in the population study of women in Gothenburg, Sweden Acta Med Scand 224 1988 549 555
22. R.J. Goldberg, C.M. Burchfiel, R. Benfante, D. Chiu, D.M. Reed, and K. Yano Lifestyle and biologic factors associated with atherosclerotic disease in middle-aged men. 20-Year findings from the Honolulu Heart Program Arch Intern Med 155 1995 686 694
23. W.B. Kannel Metabolic risk factors for coronary heart disease in women: perspective from the Framingham Study Am Heart J 114 1987 413 419
24. A.D. Liese, H.W. Hense, H. Lowel, A. Doring, M. Tietze, and U. Keil Association of serum uric acid with all-cause and cardiovascular disease mortality and incident myocardial infarction in the MONICA Augsburg cohort. World Health Organization Monitoring Trends and Determinants in Cardiovascular Diseases Epidemiology 10 1999 391 397
25. V.W. Persky, A.R. Dyer, and E. Idris-Soven Uric acid: a risk factor for coronary heart disease? Circulation 59 1979 969 977
26. E. Krishnan, J.F. Baker, D.E. Furst, and H.R. Schumacher Gout and the risk of acute myocardial infarction Arthritis Rheum 54 2006 2688 2696
27. M.J. Bos, P.J. Koudstaal, A. Hofman, J.C. Witteman, and M.M. Breteler Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam Study Stroke 37 2006 1503 1507
28. P. Verdecchia, G. Schillaci, G. Reboldi, F. Santeusanio, C. Porcellati, and P. Brunetti Relation between serum uric acid and risk of cardiovascular disease in essential hypertension. The PIUMA Study Hypertension 36 2000 1072 1078
29. B.F. Culleton, M.G. Larson, W.B. Kannel, and D. Levy Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study Ann Intern Med 131 1999 7 13
30. J.T. Moriarity, A.R. Folsom, C. Iribarren, F.J. Nieto, and W.D. Rosamond Serum uric acid and risk of coronary heart disease: Atherosclerosis Risk in Communities (ARIC) Study Ann Epidemiol 10 2000 136 143
31. F.N. Brand, D.L. McGee, W.B. Kannel, J. Stokes III, and W.P. Castelli Hyperuricemia as a risk factor of coronary heart disease: the Framingham Study Am J Epidemiol 121 1985 11 18
32. S.G. Wannamethee, A.G. Shaper, and P.H. Whincup Serum urate and the risk of major coronary heart disease events Heart 78 1997 147 153
33. C. Zoccali, R. Maio, F. Mallamaci, G. Sesti, and F. Perticone Uric acid and endothelial dysfunction in essential hypertension J Am Soc Nephrol 17 2006 1466 1471
34. J. Xu, and M.H. Zou Molecular insights and therapeutic targets for diabetic endothelial dysfunction Circulation 120 2009 1266 1286
35. K.H. Benzuly, R.C. Padgett, S. Kaul, D.J. Piegors, M.L. Armstrong, and D.D. Heistad Functional improvement precedes structural regression of atherosclerosis Circulation 89 1994 1810 1818
36. F. Galetta, F. Franzoni, and A. Virdis Endothelium-dependent vasodilation and carotid artery wall remodeling in athletes and sedentary subjects Atherosclerosis 186 2006 184 192
37. L. Lind Flow-mediated vasodilation was found to be an independent predictor of changes in the carotid plaque status during a 5-year follow-up J Atheroscler Thromb 21 2014 161 168
38. H. Kawano, T. Yoshida, and Y. Miyao The relationship between endothelial function in the brachial artery and intima plus media thickening of the coronary arteries in patients with chest pain syndrome Atherosclerosis 195 2007 361 366
39. A.F. Cicero, P. Salvi, S. D'Addato, M. Rosticci, and C. Borghi Association between serum uric acid, hypertension, vascular stiffness and subclinical atherosclerosis: data from the Brisighella Heart Study J Hypertens 32 2014 57 64
40. S. Takayama, R. Kawamoto, T. Kusunoki, M. Abe, and M. Onji Uric acid is an independent risk factor for carotid atherosclerosis in a Japanese elderly population without metabolic syndrome Cardiovasc Diabetol 11 2012 2
41. T. Montalcini, G. Gorgone, C. Gazzaruso, G. Sesti, F. Perticone, and A. Pujia Relation between serum uric acid and carotid intima-media thickness in healthy postmenopausal women Intern Emerg Med 2 2007 19 23
42. Q. Li, Z. Yang, and B. Lu Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes Cardiovasc Diabetol 10 2011 72
43. Y. Tavil, M.G. Kaya, and S.O. Oktar Uric acid level and its association with carotid intima-media thickness in patients with hypertension Atherosclerosis 197 2008 159 163
44. M.P. Kao, D.S. Ang, and S.J. Gandy Allopurinol benefits left ventricular mass and endothelial dysfunction in chronic kidney disease J Am Soc Nephrol 22 2011 1382 1389
45. S. Rekhraj, S.J. Gandy, and B.R. Szwejkowski High-dose allopurinol reduces left ventricular mass in patients with ischemic heart disease J Am Coll Cardiol 61 2013 926 932
46. H. Sakurai Urate transporters in the genomic era Curr Opin Nephrol Hypertens 22 2013 545 550
47. I.A. Bobulescu, and O.W. Moe Renal transport of uric acid: evolving concepts and uncertainties Adv Chronic Kidney Dis 19 2012 358 371
48. H. Matsuo, T. Chiba, and S. Nagamori Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia Am J Hum Genet 83 2008 744 751
49. A. Parsa, E. Brown, and M.R. Weir Genotype-based changes in serum uric acid affect blood pressure Kidney Int 81 2012 502 507
50. S.R. Giolo, A.C. Pereira, M. de Andrade, J.E. Krieger, and J.P. Soler Evaluating gene by sex and age interactions on cardiovascular risk factors in Brazilian families BMC Med Genet 11 2010 132
51. Y. Nakamura, H. Takemori, and K. Shiraishi Compensatory enlargement of angiographically normal coronary segments in patients with coronary artery disease. In vivo documentation using intravascular ultrasound Angiology 47 1996 775 781