Role of p53-fibrinolytic system cross-talk in the regulation of quartz-induced lung injury

Toxicology and Applied Pharmacology

Volumn 283, Issue 2, 2015, Pages 92-98

  Bhandary, Yashodhar P ^a   Shetty, Shwetha K ^a   Marudamuthu, Amarnath S ^a   Fu, Jian ^a,b   Pinson, Barbara M ^a,b   Levin, Jeffrey ^a   Shetty, Sreerama ^a  

^a Baylor UT Houston Center for AIDS Research   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Acute lung injury; Alveolar type II cell apoptosis; Fibrinolytic system; Silicosis

Indexed keywords

BETA ACTIN; CASPASE 3; CAVEOLIN 1; CYTOKINE; LEUKOCYTE ELASTASE; MESSENGER RNA; PHOSPHOPROTEIN PHOSPHATASE 2A; PLASMINOGEN ACTIVATOR INHIBITOR; PROTEIN P53; SILICON DIOXIDE; SURFACTANT PROTEIN C; UROKINASE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; FIBRINOLYSIS; IMMUNOBLOTTING; LUNG ALVEOLUS EPITHELIUM CELL; LUNG INJURY; MOUSE; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SILICOSIS; WILD TYPE; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; FEMALE; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY;

MUS;

ANIMALS; FEMALE; FIBRINOLYSIS; LUNG INJURY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; QUARTZ; TUMOR SUPPRESSOR PROTEIN P53; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 84921450410     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2015.01.007     Document Type: Article

References (35)

1. Arras M., Louahed J., Simoen V., Barbarin V., Misson P., van den Brûle S., Delos M., Knoops L., Renauld J.C., Lison D., Huaux F. B lymphocytes are critical for lung fibrosis control and prostaglandin E2 regulation in IL-9 transgenic mice. Am. J. Respir. Cell Mol. Biol. 2006, 34(5):573-580.
2. Bhandary Y.P., Shetty S.K., Marudamuthu A.S., Gyetko M.R., Idell S., Gharaee-Kermani M., Shetty R.S., Starcher B.C., Shetty S. Regulation of alveolar epithelial cell apoptosis and pulmonary fibrosis by coordinate expression of components of the fibrinolytic system. Am. J. Physiol. Lung Cell. Mol. Physiol. 2012, 302(5):L463-L473.
3. Bhandary Y.P., Shetty S.K., Marudamuthu A.S., Ji H.L., Neuenschwander P.F., Boggaram V., Morris G.F., Fu J., Idell S., Shetty S. Regulation of lung injury and fibrosis by p53-mediated changes in urokinase and plasminogen activator inhibitor-1. Am. J. Pathol. 2013, 183(1):131-143.
4. Borges V.M., Lopes M.F., Falcão H., Leite-Júnior J.H., Rocco P.R., Davidson W.F., Linden R., Zin W.A., DosReis G.A. Apoptosis underlies immunopathogenic mechanisms in acute silicosis. Am. J. Respir. Cell Mol. Biol. 2002, 27(1):78-84.
5. Silicosis mortality, prevention, and control-United States, 1968-2002. Centers for Disease Control and Prevention (CDC). MMWR Morb. Mortal. Wkly Rep. 2005, 54(16):401-405. (Apr 29).
6. Chu L., Wang T., Hu Y., Gu Y., Su Z., Jiang H. Activation of Egr-1 in human lung epithelial cells exposed to silica through MAPKs signaling pathways. PLoS ONE 2013, 18:8(7).
7. Davis G.S., Holmes C.E., Pfeiffer L.M., Hemenway D.R. Lymphocytes, lymphokines, and silicosis. J. Environ. Pathol. Toxicol. Oncol. 2001, 20(1):53-65.
8. Ehrlich R.I., Myers J.E., Water Naude J.M., Thompson M.L., Churchyard G.J. Lung function loss in relation to silica dust exposure in South African gold miners. Occup. Environ. Med. 2011, 68(2):96-101.
9. Healy C.B., Coggins M.A., Van T.M., MacCalman L., McGowan P. An evaluation of on-tool shrouds for controlling respirable crystalline silica in restoration stone work. Ann. Occup. Hyg. 2014, 58(9):1155-1167.
10. Hnizdo E., Vallyathan V. Chronic obstructive pulmonary disease due to occupational exposure to silica dust: a review of epidemiological and pathological evidence. Occup. Environ. Med. 2003, 60(4):237-243.
11. Iyer R., Hamilton R.F., Li L., Holian A. Silica-induced apoptosis mediated via scavenger receptor in human alveolar macrophages. Toxicol. Appl. Pharmacol. 1996, 141(1):84-92.
12. Kaewamatawong T., Kawamura N., Okajima M., Sawada M., Morita T., Shimada A. Acute pulmonary toxicity caused by exposure to colloidal silica: particle size dependent pathological changes in mice. Toxicol. Pathol. 2005, 33(7):743-749.
13. Kumar R.K., Li W., O'Grady R. Activation of lymphocytes in the pulmonary inflammatory response to silica. Immunol. Invest. 1990, 19(4):363-372.
14. Lacher S.E., Johnson C., Jessop F., Holian A., Migliaccio C.T. Murine pulmonary inflammation model: a comparative study of anesthesia and instillation methods. Inhal. Toxicol. 2010, 22(1):77-83.
15. Langley R.J., Mishra N.C., Peña-Philippides J.C., Hutt J.A., Sopori M.L. Granuloma formation induced by low-dose chronic silica inhalation is associated with an anti-apoptotic response in Lewis rats. J. Toxicol. Environ. Health A 2010, 73(10):669-683.
16. Leung C.C., Yu I.T., Chen W. Silicosis. Lancet 2012, 379(9830):2008-2018.
17. Lim Y., Kim J.H., Kim K.A., Chang H.S., Park Y.M., Ahn B.Y., Phee Y.G. Silica-induced apoptosis in vitro and in vivo. Toxicol. Lett. 1999, 108(2-3):335-339.
18. McCracken C., Zane A., Knight D.A., Dutta P.K., Waldman W.J. Minimal intestinal epithelial cell toxicity in response to short- and long-term food-relevant inorganic nanoparticle exposure. Chem. Res. Toxicol. 2013, 26(10):1514-1525. (21).
19. Nelson G., Girdler-Brown B., Ndlovu N., Murray J. Three decades of silicosis: disease trends at autopsy in South African gold miners. Environ. Health Perspect. 2010, 118(3):421-426.
20. Pfau J.C., Brown J.M., Holian A. Silica-exposed mice generate autoantibodies to apoptotic cells. Toxicology 2004, 195(2-3):167-176. (15).
21. Poggi M., Paulmyer-Lacroix O., Verdier M., Peiretti F., Bastelica D., Boucraut J., Lijnen H.R., Juhan-Vague I., Alessi M.C. Chronic plasminogen activator inhibitor-1 (PAI-1) overexpression dampens CD25+ lymphocyte recruitment after lipopolysaccharide endotoxemia in mouse lung. J. Thromb. Haemost. 2007, 5(12):2467-2475.
22. Shetty S., Pendurthi U.R., Halady P.K., Azghani A.O., Idell S. Urokinase induces its own expression in Beas2B lung epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 2002, 283(2):L319-L328.
23. Shetty S., Velusamy T., Idell S., Shetty P., Mazar A.P., Bhandary Y.P., Shetty R.S. Regulation of urokinase receptor expression by p53: novel role in stabilization of uPAR mRNA. Mol. Cell. Biol. 2007, 27(16):5607-5618.
24. Shetty P., Velusamy T., Bhandary Y.P., Shetty R.S., Liu M.C., Shetty S. Urokinase expression by tumor suppressor protein p53: a novel role in mRNA turnover. Am. J. Respir. Cell Mol. Biol. 2008, 39(3):364-372.
25. Shetty S., Shetty P., Idell S., Velusamy T., Bhandary Y.P., Shetty R.S. Regulation of plasminogen activator inhibitor-1 expression by tumor suppressor protein p53. J. Biol. Chem. 2008, 283(28):19570-19580. (11).
26. Shetty S.K., Marudamuthu A.S., Abernathy D., Shetty R.S., Shetty P., Fu J., Idell S., Bhandary Y.P., Ji H., Liu M.C., Shetty S. Regulation of urokinase expression at the posttranscription level by lung epithelial cells. Biochemistry 2012, 51(1):205-213. (10).
27. Shetty S.K., Bhandary Y.P., Marudamuthu A.S., Abernathy D., Velusamy T., Starcher B., Shetty S. Regulation of airway and alveolar epithelial cell apoptosis by p53-induced plasminogen activator inhibitor-1 during cigarette smoke exposure injury. Am. J. Respir. Cell Mol. Biol. 2012, 47(4):474-483.
28. Spitalieri P., Quitadamo M.C., Orlandi A., Guerra L., Giardina E., Casavola V., Novelli G., Saltini C., Sangiuolo F. Rescue of murine silica-induced lung injury and fibrosis by human embryonic stem cells. Eur. Respir. J. 2012, 39(2):446-457.
29. Steenland K., Ward E. Silica: a lung carcinogen. CA Cancer J. Clin. 2014, 64(1):63-69.
30. Suzuki N., Ohta K., Horiuchi T., Takizawa H., Ueda T., Kuwabara M., Shiga J., Ito K. T lymphocytes and silica-induced pulmonary inflammation and fibrosis in mice. Thorax 1996, 51(10):1036-1042.
31. US Department of Health and Human Services Progress Review: Occupational Safety and Health. Healthy People 2010 February 21, 2008 (Accessed January 6, 2010). http://www.healthypeople.gov/Data/2010prog/focus20/.
32. US Department of Labor, Bureau of Labor Statistics Workplace Injuries and Illnesses-2008 Table SNR07 October 2009 (Accessed January 6, 2010). http://www.bls.gov/iif/oshsumhtm.
33. Verma D.K., Vacek P.M., des T.K., Finkelstein M., Branch B., Gibbs G.W., Graham W.G. Silica exposure assessment in a mortality study of Vermont granite workers. J. Occup. Environ. Hyg. 2011, 8(2):71-79.
34. Wiessner J.H., Mandel N.S., Sohnle P.G., Hasegawa A., Mandel G.S. The effect of chemical modification of quartz surfaces on particulate-induced pulmonary inflammation and fibrosis in the mouse. Am. Rev. Respir. Dis. 1990, 141(1):111-116.
35. Zhang M., Zheng Y.D., Du X.Y., Lu Y., Li W.J., Qi C., Wu Z.L. Silicosis in automobile foundry workers: a 29-year cohort study. Biomed. Environ. Sci. 2010, 23(2):121-129.