Suppressive effect of insulin on the gene expression and plasma concentrations of mediators of asthmatic inflammation

Journal of Diabetes Research

Volumn 2015, Issue , 2015, Pages

  Ghanim, Husam ^a   Green, Kelly ^a   Abuaysheh, Sanaa ^a   Batra, Manav ^a   Kuhadiya, Nitesh D ^a   Patel, Reema ^a   Makdissi, Antoine ^a   Dhindsa, Sandeep ^b   Chaudhuri, Ajay ^a   Dandona, Paresh ^a  

^a GATES VASCULAR INSTITUTE AT KALEIDA HEALTH   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; ADAM33 PROTEIN; GELATINASE B; GLIBENCLAMIDE; GLIPIZIDE; GLUCOSE; INSULIN; INTERLEUKIN 4; MESSENGER RNA; METFORMIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; SODIUM CHLORIDE; THYMIC STROMAL LYMPHOPOIETIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE;

ADULT; ARTICLE; ASTHMA; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; INSULIN INFUSION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANALYSIS; BLOOD; BODY MASS; COMPLICATION; CROSSOVER PROCEDURE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; INFLAMMATION; INSULIN RESISTANCE; INTRAVENOUS DRUG ADMINISTRATION; LUMINESCENCE; METABOLISM; MIDDLE AGED; WEIGHT REDUCTION;

ADULT; ASTHMA; BLOOD GLUCOSE; BODY MASS INDEX; CROSS-OVER STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INFLAMMATION; INFUSIONS, INTRAVENOUS; INSULIN; INSULIN RESISTANCE; LUMINESCENCE; MALE; MIDDLE AGED; OBESITY; REACTIVE OXYGEN SPECIES; WEIGHT LOSS;

EID: 84921416846     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2015/202406     Document Type: Article

References (27)

1. P. Dandona, H. Ghanim, S. V. Monte et al., and quot;Increase in the mediators of asthma in obesity and obesity with type 2 diabetes: Reduction with weight loss, and " Obesity, vol. 22, no. 2, pp. 356-362, 2014.
2. C. Doucet, D. Brouty-Boyé, C. Pottin-Clémenceau, G. W. Canonica, C. Jasmin, and B. Azzarone, and quot;Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma, and quot;The Journal of Clinical Investigation, vol. 101, no. 10, pp. 2129-2139, 1998.
3. I. C. J. de Faria, E. J. de Faria, A. A. D. C. Toro, J. D. Ribeiro, and C. S. Bertuzzo, and quot;Association of TGF-1, CD14, IL-4, IL-4R and ADAM33 gene polymorphismswith asthma severity in children and adolescents, and " Jornal de Pediatria, vol. 84, no. 3, pp. 203-210, 2008.
4. S. Romagnani, and quot;Cytokines and chemoattractants in allergic inflammation, and " Molecular Immunology, vol. 38, no. 12-13, pp. 881-885, 2002.
5. T. A. Doherty, P. Soroosh, N. Khorram et al., and quot;The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling, and " Nature Medicine, vol. 17, no. 5, pp. 596-603, 2011.
6. S.-E. Dahlén, and quot;TSLP in asthma-a new kid on the block?" The NewEngland Journal ofMedicine, vol. 370, no. 22, pp. 2144-2145, 2014.
7. S. A. Kharitonov and P. J. Barnes, and quot;Effects of corticosteroids on noninvasive biomarkers of inflammation in asthma and chronic obstructive pulmonary disease, and " Proceedings of the American Thoracic Society, vol. 1, no. 3, pp. 191-199, 2004.
8. S. J. Szefler, H. Mitchell, C. A. Sorkness et al., and quot;Management of asthma based on exhaled nitric oxide in addition to guidelinebased treatment for inner-city adolescents and young adults: a randomised controlled trial, and " The Lancet, vol. 372, no. 9643, pp. 1065-1072, 2008.
9. M. Barreto, M. P. Villa, C. Olita, S. Martella, G. Ciabattoni, and P. Montuschi, and quot;8-Isoprostane in exhaled breath condensate and exercise-induced bronchoconstriction in asthmatic children and adolescents, and " Chest, vol. 135, no. 1, pp. 66-73, 2009.
10. A. Aljada, H. Ghanim, P. Mohanty, N. Kapur, and P. Dandona, and quot;Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations, and " Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 3, pp. 1419-1422, 2002.
11. P. Dandona, A. Aljada, P. Mohanty et al., and quot;Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an antiinflammatory effect?" Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 7, pp. 3257-3265, 2001.
12. H. Ghanim, K. Korzeniewski, C. L. Sia et al., and quot;Suppressive effect of insulin infusion on chemokines and chemokine receptors, and " Diabetes Care, vol. 33, no. 5, pp. 1103-1108, 2010.
13. H. Ghanim, P. Mohanty, R. Deopurkar et al., and quot;Acute modulation of toll-like receptors by insulin, and " Diabetes Care, vol. 31, no. 9, pp. 1827-1831, 2008.
14. K. Chen, Y. Xiang, X. Yao et al., and quot;The active contribution of Tolllike receptors to allergic airway inflammation, and " International Immunopharmacology, vol. 11, no. 10, pp. 1391-1398, 2011.
15. H. Ghanim, P. Mohanty, R. Pathak, A. Chaudhuri, L. S. Chang, and P. Dandona, and quot;Orange juice or fructose intake does not induce oxidative and inflammatory response, and " Diabetes Care, vol. 30, no. 6, pp. 1406-1411, 2007.
16. S. Wenzel, L. Ford, D. Pearlman et al., and quot;Dupilumab in persistent asthma with elevated eosinophil levels, and quot;The New England Journal of Medicine, vol. 368, no. 26, pp. 2455-2466, 2013.
17. M. Zhang, Z. Zhang, H.-Y. Pan, D.-X. Wang, Z.-T. Deng, and X.-L. Ye, and quot;TGF-1 induces human bronchial epithelial cell-tomesenchymal transition in vitro, and " Lung, vol. 187, no. 3, pp. 187-194, 2009.
18. L. Langouche, I. Vanhorebeek, D. Vlasselaers et al., and quot;Intensive insulin therapy protects the endothelium of critically ill patients, and " Journal of Clinical Investigation, vol. 115, no. 8, pp. 2277-2286, 2005.
19. P. Dandona, H. Ghanim, A. Bandyopadhyay et al., and quot;Insulin suppresses endotoxin-induced oxidative, nitrosative, and inflammatory stress in humans, and " Diabetes Care, vol. 33, no. 11, pp. 2416-2423, 2010.
20. D. H. Yates, and quot;Role of exhaled nitric oxide in asthma, and " Immunology and Cell Biology, vol. 79, no. 2, pp. 178-190, 2001.
21. A. Aljada, H. Ghanim, E. Assian et al., and quot;Increased IB expression and diminished nuclear NF-B in human mononuclear cells following hydrocortisone injection, and " Journal of Clinical Endocrinology and Metabolism, vol. 84, no. 9, pp. 3386-3389, 1999.
22. P. Dandona, H. Ghanim, C. L. Sia et al., and quot;A mixed antiinflammatory and pro-inflammatory response associated with a high dose of corticosteroids, and " CurrentMolecularMedicine, vol. 14, no. 6, pp. 793-801, 2014.
23. G. F. G. Bezemer, S. Sagar, J. van Bergenhenegouwen et al., and quot;Dual role of toll-like receptors in asthma and chronic obstructive pulmonary disease, and " Pharmacological Reviews, vol. 64, no. 2, pp. 337-358, 2012.
24. G. S. Hotamisligil, and quot;Inflammation and metabolic disorders, and " Nature, vol. 444, no. 7121, pp. 860-867, 2006.
25. G. Boden, P. She, M. Mozzoli et al., and quot;Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-bpathway inrat liver, and " Diabetes, vol. 54, no. 12, pp. 3458-3465, 2005.
26. D. Tripathy, P. Mohanty, S. Dhindsa et al., and quot;Elevationof free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects, and " Diabetes, vol. 52, no. 12, pp. 2882-2887, 2003.
27. K. A. Schulman, B. D. Richman, and R. E. Herzlinger, and quot;Shifting toward defined contributions-predicting the effects, and " The New England Journal of Medicine, vol. 370, no. 26, pp. 2462-2465, 2014.