Gut microbial community structure and complications after kidney transplantation: A pilot study

Transplantation

Volumn 98, Issue 7, 2014, Pages 697-705

  Lee, John R ^a,b   Muthukumar, Thangamani ^a,b   Dadhania, Darshana ^a,b   Toussaint, Nora C ^c   Ling, Lilan ^c   Pamer, Eric ^c   Suthanthiran, Manikkam ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b WEILL CORNELL MEDICAL CENTER   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

16s rRNA deep sequencing; Acute rejection; Diarrhea; Gut microbiota; Renal transplantation; Urinary tract infection

Indexed keywords

RNA 16S;

ACUTE GRAFT REJECTION; ADULT; AFRICAN AMERICAN; ARTICLE; BACTEROIDES; CAUCASIAN; CLINICAL ARTICLE; COHORT ANALYSIS; COMMUNITY STRUCTURE; CONTROLLED STUDY; COPROCOCCUS; DIARRHEA; DOREA; EFFECT SIZE; ENTEROCOCCUS; FECAL ABUNDANCE; FEMALE; HISPANIC; HUMAN; INTESTINE FLORA; KIDNEY TRANSPLANTATION; LACHNOSPIRACEAE; MALE; MICROBIAL COMMUNITY; NONHUMAN; PILOT STUDY; POLYMERASE CHAIN REACTION; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; POSTTRANSPLANT DIARRHEA; PRIORITY JOURNAL; PROSPECTIVE STUDY; RUMINOCOCCUS; URINARY TRACT INFECTION; AGED; COMPLICATION; FECES; GENETICS; HIGH THROUGHPUT SEQUENCING; INTESTINE; ISOLATION AND PURIFICATION; KIDNEY FAILURE, CHRONIC; MICROBIOLOGY; MICROFLORA; MIDDLE AGED; PROTEOBACTERIA; STATISTICAL MODEL;

ADULT; AGED; DIARRHEA; ENTEROCOCCUS; FECES; FEMALE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; INTESTINES; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; LINEAR MODELS; MALE; MICROBIOTA; MIDDLE AGED; PILOT PROJECTS; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; PROTEOBACTERIA; RNA, RIBOSOMAL, 16S;

EID: 84921384307     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0000000000000370     Document Type: Article

References (22)

1. Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486: 207.
2. Oh PL, Martinez I, Sun Y, et al. Characterization of the ileal microbiota in rejecting and nonrejecting recipients of small bowel transplants. Am J Transplant 2012; 12: 753.
3. Taur Y, Xavier JB, Lipuma L, et al. Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis 2012; 55: 905.
4. Vaziri ND, Wong J, Pahl M, et al. Chronic kidney disease alters intestinal microbial flora. Kidney Int 2013; 83: 308.
5. Magurran AE. Biological diversity. Curr Biol 2005; 15: R116.
6. Prideaux L, Kang S, Wagner J, et al. Impact of ethnicity, geography, and disease on the microbiota in health and inflammatory bowel disease. Inflamm Bowel Dis 2013; 19: 2906.
7. Lozupone C, Knight R. UniFrac: A new phylogenetic method for comparing microbial communities. Appl Environ Microbiol 2005; 71: 8228.
8. Segata N, Izard J, Waldron L, et al. Metagenomic biomarker discovery and explanation. Genome Biol 2011; 12: R60.
9. Don Brenner, NK, James Staley. Bergey's Manual of Systematic Bacteriology, 2nd edition. William and Wilkins, 2005.
10. Bunnapradist S, Neri L, Wong W, et al. Incidence and risk factors for diarrhea following kidney transplantation and association with graft loss and mortality. Am J Kidney Dis 2008; 51: 478.
11. Coste JF, Vuiblet V, Moustapha B, et al. Microbiological diagnosis of severe diarrhea in kidney transplant recipients by use of multiplex PCR assays. J Clin Microbiol 2013; 51: 1841.
12. Arslan H, Inci EK, Azap OK, et al. Etiologic agents of diarrhea in solid organ recipients. Transpl Infect Dis 2007; 9: 270.
13. Ramakrishna BS. Role of the gut microbiota in human nutrition and metabolism. J Gastroenterol Hepatol 2013; 28(suppl 4): 9.
14. Wexler HM. Bacteroides: The good, the bad, and the nitty-gritty. Clin Microbiol Rev 2007; 20: 593.
15. Bunnapradist S, Lentine KL, Burroughs TE, et al. Mycophenolate mofetil dose reductions and discontinuations after gastrointestinal complications are associated with renal transplant graft failure. Transplantation 2006; 82: 102.
16. Knoll GA, MacDonald I, Khan A, et al. Mycophenolate mofetil dose reduction and the risk of acute rejection after renal transplantation. J Am Soc Nephrol 2003; 14: 2381.
17. Jenq RR, Ubeda C, Taur Y, et al. Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. J Exp Med 2012; 209: 903.
18. Ubeda C, Taur Y, Jenq RR, et al. Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans. J Clin Invest 2010; 120: 4332.
19. Schloss PD, Westcott SL, Ryabin T, et al. Introducing mothur: opensource, platform-independent, community-supported software for describing and comparing microbial communities. Appl Environ Microbiol 2009; 75: 7537.
20. Pruesse E, Quast C, Knittel K, et al. SILVA: A comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB. Nucleic Acids Res 2007; 35: 7188.
21. Racusen LC, Colvin RB, Solez K, et al. Antibody-mediated rejection criteria -An addition to the Banff 97 classification of renal allograft rejection. Am J Transplant 2003; 3: 708.
22. Sheneman L, Evans J, Foster JA. Clearcut: A fast implementation of relaxed neighbor joining. Bioinformatics 2006; 22: 2823.