Effect of 2-hydroxy-4-methylthio-butanoic acid on ruminal fermentation, bacterial distribution, digestibility, and performance of lactating dairy cows

Journal of Dairy Science

Volumn 98, Issue 2, 2015, Pages 1234-1247

  Lee, C ^a   Oh, J ^a   Hristov, A N ^a   Harvatine, K ^a   Vazquez Anon, M ^b   Zanton, G I ^b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b NOVUS INTERNATIONAL INC   (United States)

Author keywords

2 hydroxy 4 methylthio butanoic acid; Dairy cow; Rumen bacteria; Rumen fermentation

Indexed keywords

BACTERIA (MICROORGANISMS); PREVOTELLA LOESCHEII; PREVOTELLA ORALIS;

ALPHA-HYDROXY-GAMMA-METHYLMERCAPTOBUTYRIC ACID; AMMONIA; BUTYRIC ACID; FAT; FATTY ACID; METHIONINE; NITROGEN; PROTEIN INTAKE; VOLATILE FATTY ACID;

ANALOGS AND DERIVATIVES; ANIMAL; BACTERIUM; BOVINE; CHEMISTRY; CLASSIFICATION; DIET SUPPLEMENTATION; DIGESTION; DRUG EFFECTS; FEMALE; FERMENTATION; ISOLATION AND PURIFICATION; LACTATION; METABOLISM; MICROBIOLOGY; MILK; PH; PHYSIOLOGY; PROTEIN INTAKE; RUMINANT STOMACH; URINE;

AMMONIA; ANIMALS; BACTERIA; BUTYRIC ACID; CATTLE; DIETARY PROTEINS; DIETARY SUPPLEMENTS; DIGESTION; FATS; FATTY ACIDS; FATTY ACIDS, VOLATILE; FEMALE; FERMENTATION; HYDROGEN-ION CONCENTRATION; LACTATION; METHIONINE; MILK; NITROGEN; RUMEN;

EID: 84921348391     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2014-8904     Document Type: Article

References (66)

1. Official Methods of Analysis 2000, AOAC International, AOAC Int., Arlington, VA. 17th.
2. Official Methods of Analysis 2002, AOAC International, AOAC Int., Arlington, VA. 17th ed. 1st rev.
3. Baldin M., Ying J.Y., Zanton G.I., Harvatine K.J. Effect of 2-hydroxy-4-(methylthio)butanoate (HMTBa) on risk of diet-induced milk fat depression. J. Dairy Sci. 2014, 97(E-Suppl. 1):358. (Abstr.).
4. Binnerts W.T., Van't Klooster A.T., Frens A.M. Soluble chromium indicator measured by atomic absorption in digestion experiments. Vet. Rec. 1968, 82:470.
5. Broderick G.A., Kowalczyk T., Satter L.D. Milk production response to supplementation with encapsulated methionine per os or casein per abomasum. J. Dairy Sci. 1970, 53:1714-1721.
6. Broderick G.A., Satter L.D., Harper A.E. Use of plasma amino acid concentration to identify limiting amino acids for milk production. J. Dairy Sci. 1974, 57:1015-1023.
7. Caporaso J.G., Lauber C.L., Walters W.A., Berg-Lyons D., Lozupone C.A., Turnbaugh P.J., Fierer N., Knight R. Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample. Proc. Natl. Acad. Sci. USA 2011, 108:4516-4522.
8. Chen X.B., Chen Y.K., Franklin M.F., Ørskov E.R., Shand W.J. The effect of feed intake and body weight on purine derivative excretion and microbial protein supply in sheep. J. Anim. Sci. 1992, 70:1534-1542.
9. Chen Z.H., Broderick G.A., Luchini N.D., Sloan B.K., Devillard E. Effect of feeding different sources of rumen-protected methionine on milk production and N-utilization in lactating dairy cows. J. Dairy Sci. 2011, 94:1978-1988.
10. Combs D.K., Satter L.D. Determination of markers in digesta and feces by direct current plasma emission spectroscopy. J. Dairy Sci. 1992, 75:2176-2183.
11. Cotta M.A., Russell J.B. Effect of peptides and amino acids on efficiency of rumen bacterial protein synthesis in continuous culture. J. Dairy Sci. 1982, 65:226-234.
12. DeSantis T.Z., Hugenholtz P., Larsen N., Rojas M., Brodie E.L., Keller K., Huber T., Dalevi D., Hu P., Andersen G.L. Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB. Appl. Environ. Microbiol. 2006, 72:5069-5072.
13. DeVries T.J., von Keyserlingk M.A.G., Beauchemin K.A. Short Communication: Diurnal feeding pattern of lactating dairy cows. J. Dairy Sci. 2003, 86:4079-4082.
14. Dewhurst R.J., Moorby J.M., Vlaeminck B., Van Nespen T., Fievez V. Apparent recovery of duodenal odd- and branched-chain fatty acids in milk. J. Dairy Sci. 2007, 90:1775-1780.
15. Dibner J.J. Review of the metabolism of 2-hydroxy-4- (methylthio) butanoic acid. World's Poult. Sci. J. 2003, 59:99-110.
16. Dijkstra J., van Zijderveld S.M., Apajalahti J.A., Bannink A., Gerrits W.J.J., Newbold J.R., Perdok H.B., Berends H. Relationships between methane production and milk fatty acid profiles in dairy cattle. Anim. Feed Sci. Technol. 2011, 166-167:590-595.
17. Fievez V., Colman E., Castro-Montoya J.M., Stefanov I., Vlaeminck B. Milk odd- and branched-chain fatty acids as biomarkers of rumen function-An update. Anim. Feed Sci. Technol. 2012, 172:51-65.
18. France J., Siddons R.C. Determination of digesta flow by continuous marker infusion. J. Theor. Biol. 1986, 121:105-120.
19. French E.A., Bertics S.J., Armentano L.E. Rumen and milk odd- and branched-chain fatty acid proportions are minimally influenced by ruminal volatile fatty acid infusions. J. Dairy Sci. 2012, 95:2015-2026.
20. Griel L.C., Patton R.A., McCarthy R.D., Chandler P.T. Milk production response to feeding methionine hydroxyl analog to lactating dairy cows. J. Dairy Sci. 1968, 51:1866-1868.
21. Holter J.B., Kim C.W., Colovos N.F. Methionine hydroxy analog for lactating dairy cows. J. Dairy Sci. 1972, 55:460-465.
22. Hristov A.N. Comparative characterization of reticular and duodenal digesta and possibilities to estimate microbial outflow from the rumen based on reticular sampling in dairy cows. J. Anim. Sci. 2007, 85:2606-2613.
23. Hristov A.N., Lee C., Cassidy T., Long M., Heyler K., Corl B., Forster R. Effects of lauric and myristic acids on ruminal fermentation, production, and milk fatty acid composition in lactating dairy cows. J. Dairy Sci. 2011, 94:382-395.
24. Hristov A.N., Lee C., Hristova R.A., Huhtanen P., Firkins J. A meta-analysis of the variability in continuous culture rumen fermentation and digestibility data. J. Dairy Sci. 2012, 95:5299-5307.
25. Hristov A.N., McAllister T.A., Ouellet D.R., Broderick G.A. Comparison of purines and nitrogen-15 as microbial flow markers in beef heifers fed barley- or corn-based diets. Can. J. Anim. Sci. 2005, 85:211-222. b.
26. Hristov A.N., Ropp J.K. Effect of dietary carbohydrate composition and availability on utilization of ruminal ammonia nitrogen for milk protein synthesis in dairy cows. J. Dairy Sci. 2003, 86:2416-2427.
27. Hristov A.N., Ropp J.K., Grandeen K.L., Abedi S., Etter R.P., Melgar A., Foley A.E. Effect of carbohydrate source on ammonia utilization in lactating dairy cows. J. Anim. Sci. 2005, 83:408-421. a.
28. Hristov A.N., Vander Pol M., Agle M., Zaman S., Schneider C., Ndegwa P., Vaddella V.K., Johnson K., Shingfield K.J., Karnati S.K. Effect of lauric acid and coconut oil on ruminal fermentation, digestion, ammonia losses from manure, and milk fatty acid composition in lactating cows. J. Dairy Sci. 2009, 92:5561-5582.
29. Huber J.T., Emery R.S., Bergen W.G., Liesman J.S., Kung L., King K.J., Gardner R.W., Checketts M. Influences of methionine hydroxy analog on milk and milk fat production, blood serum lipids, and plasma amino acids. J. Dairy Sci. 1984, 67:2525-2531.
30. Huhtanen P., Kaustell K., Jaakkola S. The use of internal markers to predict total digestibility and duodenal flow of nutrients in cattle given six different diets. Anim. Feed Sci. Technol. 1994, 48:211-227.
31. Jendza J.A., Geraert P.A., Ragland D., Adeola O. The site of intestinal disappearance of DL-methionine and methionine hydroxy analog differs in pigs. J. Anim. Sci. 2011, 89:1385-1391.
32. Johnson-VanWieringen L.M., Harrison J.H., Davidson D., Swift M.L., von Keyserlingk M.A.G., Vazquez-Anon M., Wright D., Chalupa W. Effects of rumen undegradable protein sources and supplemental 2-hydroxy-4-(methylthio)-butanoic acid and lysine-HCl on lactation performance in dairy cows. J. Dairy Sci. 2007, 90:5176-5188.
33. Karnati S.K.R., Sylvester J.T., Noftsger S.M., Yu Z., St-Pierre N.R., Firkins J.L. Assessment of ruminal bacterial populations and protozoal generation time in cows fed different methionine sources. J. Dairy Sci. 2007, 90:798-809.
34. Keeney M., Katz I., Allison M.J. On the probable origin of some milk fat acids in rumen microbial lipids. J. Am. Oil Chem. Soc. 1962, 39:198-201.
35. Knight C.D., Dibner A.J. Comparative absorption of 2-hydroxy-4-(methylthio)-butanoic acid and L-methionine in the broiler chick. J. Nutr. 1984, 114:2179-2186.
36. Knudsen K.E.B. Carbohydrate and lignin contents of plant materials used in animal feeding. Anim. Feed Sci. Technol. 1997, 67:319-338.
37. Koenig K.M., Rode L.M., Knight C.D., McCullough P.R. Ruminal escape, gastrointestinal absorption, and response of serum methionine to supplementation of liquid methionine hydroxy analog in dairy cows. J. Dairy Sci. 1999, 82:355-361.
38. Koenig K.M., Rode L.M., Knight C.D., Vazquez-Añon M. Rumen degradation and availability of various amounts of liquid methionine hydroxy analog in lactating dairy cows. J. Dairy Sci. 2002, 85:930-938.
39. Lapierre H., Vázquez-Añón M., Parker D., Dubreuil P., Holtrop G., Lobley G.E. Metabolism of 2-hydroxy-4-(methylthio) butanoate (HMTBA) in lactating dairy cows. J. Dairy Sci. 2011, 94:1526-1535.
40. Lee C., Hristov A.N., Cassidy T.W., Heyler K.S., Lapierre H., Varga G.A., de Veth M.J., Patton R.A., Parys C. Rumen-protected lysine, methionine, and histidine increase milk protein yield in dairy cows fed a metabolizable protein-deficient diet. J. Dairy Sci. 2012, 95:6042-6056.
41. Lobley G.E., Wester T.J., Calder A.G., Parker D.S., Dibner J.J., Vázquez-Añón M. Absorption of 2-hydroxy-4-methylthiobutyrate and conversion to methionine in lambs. J. Dairy Sci. 2006, 89:1072-1080.
42. Lundquist R.G., Linn J.G., Otterby D.E. Influence of dietary energy and protein on yield and composition of milk from cows fed methionine hydroxyl analog. J. Dairy Sci. 1983, 66:475-491.
43. Martin C., Mirande C., Morgavi D.P., Forano E., Devillard E., Mosoni P. Methionine analogues HMB and HMBi increase the abundance of cellulolytic bacterial representatives in the rumen of cattle with no direct effects on fibre degradation. Anim. Feed Sci. Technol. 2013, 182:16-24.
44. McCollum M.Q., Vázquez-Añón M., Dibner J.J., Webb K.E. Absorption of 2-hydroxy-4-(methylthio)butanoic acid by isolated sheep ruminal and omasal epithelia. J. Anim. Sci. 2000, 78:1078-1083.
45. Mohammed R., McGinn S.M., Beauchemin K.A. Prediction of enteric methane output from milk fatty acid concentrations and rumen fermentation parameters in dairy cows fed sunflower, flax, or canola seeds. J. Dairy Sci. 2011, 94:6057-6068.
46. Noftsger S., St-Pierre N.R., Sylvester J.T. Determination of rumen degradability and ruminal effects of three sources of methionine in lactating cows. J. Dairy Sci. 2005, 88:223-237.
47. Noftsger S.M., St-Pierre N.R., Karnati S.K.R., Firkins J.L. Effects of 2-hydroxy-4-(methylthio) butanoic acid (HMB) on microbial growth in continuous culture. J. Dairy Sci. 2003, 86:2629-2636.
48. Nutrient Requirements of Dairy Cattle 2001, NRC, Natl. Acad. Sci. Washington, DC. 7th rev.
49. Piepenbrink M.S., Marr A.L., Waldron M.R., Butler W.R., Overton T.R., Vazquez-Añon M., Holt M.D. Feeding 2-hydroxy-4-(methylthio)-butanoic acid to periparturient dairy cows improves milk production but not hepatic metabolism. J. Dairy Sci. 2004, 87:1071-1084.
50. Rico D.E., Harvatine K.J. Induction of and recovery from milk fat depression occurs progressively in dairy cows switched between diets that differ in fiber and oil concentration. J. Dairy Sci. 2013, 96:6621-6630.
51. Rulquin H., Graulet B., Delaby L., Robert J.C. Effect of different forms of methionine on lactational performance of dairy cows. J. Dairy Sci. 2006, 89:4387-4394.
52. Russell J.B. Effect of amino acids on the heat production and growth efficiency of Streptococcus bovis: balance of anabolic and catabolic rates. Appl. Environ. Microbiol. 1993, 59:1747-1751.
53. Schneider B.H., Flatt W.P. The evaluation of feeds through digestibility experiments 1975, University of Georgia Press, Athens, GA.
54. Schwab C.G., Satter L.D., Clay A.B. Response of lactating dairy cows to abomasal infusion of amino acids. J. Dairy Sci. 1976, 59:1254-1270.
55. Sklan D., Tinsky M. Production responses of high producing cows fed rumen bypass DL-2-hydroxy-4-(methylthio) butanoic acid coated with calcium soaps of fatty acids. Livest. Prod. Sci. 1996, 45:149-154.
56. St-Pierre N.R., Sylvester J.T. Effects of 2-hydroxy-4-(methylthio) butanoic acid (HMB) and its isopropyl ester on milk production and composition by Holstein cows. J. Dairy Sci. 2005, 88:2487-2497.
57. Uchida K., Mandebvu P., Ballard C.S., Sniffen C.J., Carter M.P. Effect of feeding methionine supplements with different rumen escape values on performance of high producing dairy cows in early lactation. Anim. Feed Sci. Technol. 2003, 107:1-14.
58. Van Kessel J.S., Russell J.B. The effect of amino nitrogen on the energetics of ruminal bacteria and its impact on energy spilling. J. Dairy Sci. 1996, 79:1237-1243.
59. Van Soest P.J., Robertson J.B., Lewis B.A. Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. J. Dairy Sci. 1991, 74:3583-3597.
60. Vazquez-Añon M., Cassidy T., McCullough P., Varga G.A. Effects of Alimet on nutrient digestibility, bacterial protein synthesis, and ruminal disappearance during continuous culture. J. Dairy Sci. 2001, 84:159-166.
61. Vazquez-Añon M., Gonzalez-Esquerra R., Yi I.G., Knight C.D. A multiple regression model approach to contrast the performance of 2-hydroxy-4-methylthio butanoci acid and DL-methionine supplementation tested in broiler experiments and reported in the literature. Poult. Sci. 2006, 85:693-705.
62. Vedenov D., Pesti G.M. An economic analysis of methionine source comparison response model. Poult. Sci. 2010, 89:2514-2520.
63. Vlaeminck B., Fievez V., Cabrita A.R.J., Fonseca A.J.M., Dewhurst R.J. Factors affecting odd- and branched-chain fatty acids in milk: A review. Anim. Feed Sci. Technol. 2006, 131:389-417.
64. Wang C., Liu H.Y., Wang Y.M., Yang Z.Q., Liu J.X., Wu Y.M., Yan T., Ye H.W. Effects of dietary supplementation of methionine and lysine on milk production and nitrogen utilization in dairy cows. J. Dairy Sci. 2010, 93:3661-3670.
65. Zanton G.I., Bettis S.E., Vazquez-Anon M. Plasma L-methionine and supplemental L-methionine precursor responses to rumen administration of a rumen protected DL-methionine source or different levels of 2-hydroxy-4-methylthio-butanoic acid. J. Dairy Sci. 2014, 97(E-Suppl. 1):755. (Abstr.).
66. Zelenka J., Heger J., Machander V., Wiltafsky M., Lešták M. Bioavailability of liquid methionine hydroxy analogue-free acid relative to dl-methionine in broilers. Acta Univ. Agric. Silv. Mendelianae Brunensis 2013, 168:1513-1520.