Hyperketonemia (acetoacetate) upregulates NADPH oxidase 4 and elevates oxidative stress, ICAM-1, and monocyte adhesivity in endothelial cells

Cellular Physiology and Biochemistry

Volumn 35, Issue 1, 2015, Pages 364-373

  Kanikarla Marie, Preeti ^a   Jain, Sushil K ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Acetoacetate; and type 1 diabetes; ICAM 1; NOX4; ROS

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; GLUCOSE; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; KETONE; KETONE BODY; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMALL INTERFERING RNA; ACETOACETIC ACID DERIVATIVE; NOX4 PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ANTISENSE THERAPY; ARTICLE; CELL ADHESION; CELL DAMAGE; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; HYPERKETONEMIA; INSULIN DEFICIENCY; INSULIN DEPENDENT DIABETES MELLITUS; LEUKOCYTE ADHERENCE; MONOCYTE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; RNA INTERFERENCE;

3-HYDROXYBUTYRIC ACID; ACETOACETATES; CELL ADHESION; CELL LINE; CELL SURVIVAL; GLUCOSE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MONOCYTES; NADPH OXIDASE; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 84921341806     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000369702     Document Type: Article

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