Topography of brain glucose hypometabolism and epileptic network in glucose transporter 1 deficiency

Epilepsy Research

Volumn 110, Issue , 2015, Pages 206-215

  Akman, Cigdem Inan ^a   Provenzano, Frank ^a   Wang, Dong ^a   Engelstad, Kristin ^a   Hinton, Veronica ^a   Yu, Julia ^a   Tikofsky, Ronald ^a   Ichese, Masonari ^a   De Vivo, Darryl C ^a  

^a Columbia University College of Physician and Surgeons ^*  (United States)

Author keywords

Brain glucose metabolism; Glucose transporter deficiency; Positron emission tomography; Statistical parametric mapping

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 1; RADIOPHARMACEUTICAL AGENT; SLC2A1 PROTEIN, HUMAN;

ADULT; ARTICLE; BRAIN MAPPING; BRAIN METABOLISM; CEREBELLUM; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; DISORDERS OF CARBOHYDRATE METABOLISM; EPILEPSY; FRONTAL CORTEX; GLUCOSE HYPOMETABOLISM; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLUCOSE TRANSPORTER 1 DEFICIENCY SYNDROME; HEAD CIRCUMFERENCE; HUMAN; IMAGE ANALYSIS; POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE ANALYSIS; TEMPORAL CORTEX; THALAMUS; ADOLESCENT; BRAIN; CHILD; COHORT ANALYSIS; DEFICIENCY; DIAGNOSTIC USE; GENETICS; INFANT; METABOLISM; MIDDLE AGED; NERVE TRACT; PRESCHOOL CHILD; SCINTISCANNING; SIGNAL PROCESSING; YOUNG ADULT;

ADOLESCENT; ADULT; BRAIN; BRAIN MAPPING; CARBOHYDRATE METABOLISM, INBORN ERRORS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; EPILEPSY; FLUORODEOXYGLUCOSE F18; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; HUMANS; INFANT; MIDDLE AGED; MONOSACCHARIDE TRANSPORT PROTEINS; NEURAL PATHWAYS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; SIGNAL PROCESSING, COMPUTER-ASSISTED; YOUNG ADULT;

EID: 84921322565     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2014.11.007     Document Type: Article

References (46)

1. Akman C.I., Engelstad K., Hinton V.J., Ullner P., Koenigsberger D., Leary L., et al. Acute hyperglycemia produces transient improvement in glucose transporter type 1 deficiency. Ann. Neurol. 2010, 67:31-40.
2. Banerjee P.K., Snead O.C. Thalamic mediodorsal and intralaminar nuclear lesions disrupt the generation of experimentally induced generalized absence-like seizures in rats. Epilepsy Res. 1994, 17:193-205.
3. Bentourkia M., Michel C., Ferriere G., Bol A., Coppens A., Sibomana M., et al. Evolution of brain glucose metabolism with age in epileptic infants, children and adolescents. Brain Dev. 1998, 20:524-529.
4. Chan C.H., Briellmann R.S., Pell G.S., Scheffer I.E., Abbott D.F., Jackson G.D. Thalamic atrophy in childhood absence epilepsy. Epilepsia 2006, 47:399-405.
5. Choeiri C., Staines W., Messier C. Immunohistochemical localization and quantification of glucose transporters in the mouse brain. Neuroscience 2002, 111:19-34.
6. Chugani H.T. A critical period of brain development: studies of cerebral glucose utilization with PET. Prev. Med. 1998, 27:184-188.
7. Coenen A.M., Drinkenburg W.H., Inoue M., van Luijtelaar E.L. Genetic models of absence epilepsy, with emphasis on the WAG/Rij strain of rats. Epilepsy Res. 1992, 12:75-86.
8. Coulter D.A., Huguenard J.R., Prince D.A. Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade. Br. J. Pharmacol. 1990, 100:807-813.
9. Crunelli V., Leresche N. Childhood absence epilepsy: genes, channels, neurons and networks. Nat. Rev. Neurosci. 2002, 3:371-382.
10. Cummings T.J., Chugani D.C., Chugani H.T. Positron emission tomography in pediatric epilepsy. Neurosurg. Clin. N. Am. 1995, 6:465-472.
11. de Curtis M., Avanzini G. Thalamic regulation of epileptic spike and wave discharges. Funct. Neurol. 1994, 9:307-326.
12. De Vivo D.C., Leary L., Wang D. Glucose transporter 1 deficiency syndrome and other glycolytic defects. J. Child Neurol. 2002, 17(Suppl. 3). 3S15-3S23; discussion 3S24-3S25.
13. De Vivo D.C., Trifiletti R.R., Jacobson R.I., Ronen G.M., Behmand R.A., Harik S.I. Defective glucose transport across the blood-brain barrier as a cause of persistent hypoglycorrhachia, seizures, and developmental delay. N. Engl. J. Med. 1991, 325:703-709.
14. Dobrogowska D.H., Vorbrodt A.W. Quantitative immunocytochemical study of blood-brain barrier glucose transporter (GLUT-1) in four regions of mouse brain. J. Histochem. Cytochem. 1999, 47:1021-1030.
15. Duncan J.D., Moss S.D., Bandy D.J., Manwaring K., Kaplan A.M., Reiman E.M., et al. Use of positron emission tomography for presurgical localization of eloquent brain areas in children with seizures. Pediatr. Neurosurg. 1997, 26:144-156.
16. Engel J. The use of positron emission tomographic scanning in epilepsy. Ann. Neurol. 1984, 15(Suppl.):S180-S191.
17. Ichise M., Vines D.C., Gura T., Anderson G.M., Suomi S.J., Higley J.D., et al. Effects of early life stress on [11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer- and mother-reared rhesus monkeys. J. Neurosci. 2006, 26:4638-4643.
18. Kaufmann P., Shungu D.C., Sano M.C., Jhung S., Engelstad K., Mitsis E., Mao X., Shanske S., Hirano M., DiMauro S., De Vivo D.C. Neurol. 2004, 62(8):1297-1302.
19. Kinnala A., Suhonen-Polvi H., Aarimaa T., Kero P., Korvenranta H., Ruotsalainen U., et al. Cerebral metabolic rate for glucose during the first six months of life: an FDG positron emission tomography study. Arch. Dis. Child. Fetal Neonatal Ed. 1996, 74:F153-F157.
20. Labate A., Briellmann R.S., Abbott D.F., Waites A.B., Jackson G.D. Typical childhood absence seizures are associated with thalamic activation. Epileptic Disord. 2005, 7:373-377.
21. Leary L.D., Wang D., Nordli D.R., Engelstad K., De Vivo D.C. Seizure characterization and electroencephalographic features in Glut-1 deficiency syndrome. Epilepsia 2003, 44:701-707.
22. Liu Z., Vergnes M., Depaulis A., Marescaux C. Evidence for a critical role of GABAergic transmission within the thalamus in the genesis and control of absence seizures in the rat. Brain Res. 1991, 545:1-7.
23. Liu Z., Vergnes M., Depaulis A., Marescaux C. Involvement of intrathalamic GABAB neurotransmission in the control of absence seizures in the rat. Neuroscience 1992, 48:87-93.
24. McCormick D.A., Contreras D. On the cellular and network bases of epileptic seizures. Annu. Rev. Physiol. 2001, 63:815-846.
25. McMurtray A.M., Licht E., Yeo T., Krisztal E., Saul R.E., Mendez M.F. Positron emission tomography facilitates diagnosis of early-onset Alzheimer's disease. Eur. Neurol. 2008, 59:31-37.
26. Muzik O., Chugani D.C., Juhasz C., Shen C., Chugani H.T. Statistical parametric mapping: assessment of application in children. Neuroimage 2000, 12:538-549.
27. Neglig A., De Vasconcelos A.P., Boyet S. Quantitative autoradiographic measurement of local cerebral glucose utilization in freely moving rats during postnatal development. J. Neurosci. 1988, 8:2321-2333.
28. Niedermeyer E. Primary (idiopathic) generalized epilepsy and underlying mechanisms. Clin. Electroencephalogr. 1996, 27:1-21.
29. Pascual J.M., Van Heertum R.L., Wang D., Engelstad K., De Vivo D.C. Imaging the metabolic footprint of Glut1 deficiency on the brain. Ann. Neurol. 2002, 52:458-464.
30. Pascual J.M., Wang D., Hinton V., Engelstad K., Saxena C.M., Van Heertum R.L., et al. Brain glucose supply and the syndrome of infantile neuroglycopenia. Arch. Neurol. 2007, 64:507-513.
31. Pearson T.S., Akman C., Hinton V.J., Engelstad K., De Vivo D.C. Phenotypic spectrum of glucose transporter type 1 deficiency syndrome (Glut1 DS). Curr. Neurol. Neurosci. Rep. 2013, 13:342.
32. Pong A.W., Geary B.R., Engelstad K.M., Natarajan A., Yang H., De Vivo D.C. Glucose transporter type I deficiency syndrome: epilepsy phenotypes and outcomes. Epilepsia 2012, 53:1503-1510.
33. Richards D.A., Lemos T., Whitton P.S., Bowery N.G. Extracellular GABA in the ventrolateral thalamus of rats exhibiting spontaneous absence epilepsy: a microdialysis study. J. Neurochem. 1995, 65:1674-1680.
34. Rintahaka P.J., Chugani H.T., Messa C., Phelps M.E. Hemimegalencephaly: evaluation with positron emission tomography. Pediatr. Neurol. 1993, 9:21-28.
35. Salek-Haddadi A., Lemieux L., Merschhemke M., Friston K.J., Duncan J.S., Fish D.R. Functional magnetic resonance imaging of human absence seizures. Ann. Neurol. 2003, 53:663-667.
36. Schapiro M.B., Haxby J.V., Grady C.L. Nature of mental retardation and dementia in Down syndrome: study with PET, CT, and neuropsychology. Neurobiol. Aging 1992, 13:723-734.
37. Shouse M.N., Stroh P.J., Vreeken T. Temporal lobe and petit mal antiepileptics differentially affect ventral lateral thalamic and motor cortex excitability patterns. Brain Res. 1988, 473:372-379.
38. Snead O.C. Basic mechanisms of generalized absence seizures. Ann. Neurol. 1995, 37:14657.
39. Snead O.C., Hechler V., Vergnes M., Marescaux C., Maitre M. Increased gamma hydroxybutyric acid receptors in thalamus of a genetic animal model of petit mal epilepsy. Epilepsy Res. 1990, 7:121-128.
40. Swartz B.E., Thomas K., Simpkins F., Kovalik E., Mandelkern M.M. Rapid quantitative analysis of individual (18) FDG-PET scans. Clin. Positron Imaging 1999, 2:47-56.
41. Talairach J., Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain 1988, Thieme, Stuttgart.
42. Tucker D.M., Brown M., Luu P., Holmes M.D. Discharges in ventromedial frontal cortex during absence spells. Epilepsy Behav. 2007, 11:546-557.
43. von Krosigk M., Bal T., McCormick D.A. Cellular mechanisms of a synchronized oscillation in the thalamus. Science 1993, 261:361-364.
44. von Moers A., Brockmann K., Wang D., Korenke C.G., Huppke P., De Vivo D.C., et al. EEG features of glut-1 deficiency syndrome. Epilepsia 2002, 43:941-945.
45. Wallenstein G.V. The role of thalamic IGABAB in generating spike-wave discharges during petit mal seizures. Neuroreport 1994, 5:1409-1412.
46. Zeller K., Rahner-Welsch S., Kuschinsky W. Distribution of Glut1 glucose transporters in different brain structures compared to glucose utilization and capillary density of adult rat brains. J. Cereb. Blood Flow Metab. 1997, 17:204-209.