Safety and efficacy of isotonic (0.9%) vs. hypotonic (0.18%) saline as maintenance intravenous fluids in children: A randomized controlled trial

Indian Pediatrics

Volumn 51, Issue 12, 2014, Pages 969-974

  Shamim, Ahmar ^a,b   Afzal, Kamran ^a   Manazir Ali, S ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

^b Mahatma Gandhi Mission's Hospital   (India)

Author keywords

Hyponatremia; Intravenous fluids; Normal saline; Parenteral fluid therapy

Indexed keywords

CHLORIDE; CREATININE; GLUCOSE; HYPOTONIC SALINE; INFUSION FLUID; ISOTONIC SALINE; POTASSIUM; SODIUM; SODIUM CHLORIDE; UNCLASSIFIED DRUG; UREA;

ACUTE HEPATITIS; AGE; ARTICLE; BODY MASS; BODY SURFACE; CHILD; CHLORIDE BLOOD LEVEL; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DEATH; DRUG EFFICACY; DRUG SAFETY; FEMALE; FLUID THERAPY; GENDER; GLUCOSE BLOOD LEVEL; HOSPITAL ADMISSION; HUMAN; HYPONATREMIA; INFANT; INFECTION; MAJOR CLINICAL STUDY; MALE; MENINGOENCEPHALITIS; MORBIDITY; POTASSIUM BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; SERUM OSMOLALITY; SIDE EFFECT; SODIUM BLOOD LEVEL; TEACHING HOSPITAL; UREA BLOOD LEVEL; URINE PH; URINE VOLUME; WEIGHT CHANGE; ADVERSE EFFECTS; BLOOD; PRESCHOOL CHILD; PROCEDURES;

CHILD; CHILD, PRESCHOOL; FEMALE; FLUID THERAPY; HUMANS; HYPONATREMIA; INFANT; MALE; SODIUM; SODIUM CHLORIDE;

EID: 84921033349     PISSN: 00196061     EISSN: 09747559     Source Type: Journal    
DOI: 10.1007/s13312-014-0542-5     Document Type: Article

References (16)

1. Holliday MA, Segar ME. Maintenance need for water in parenteral fluid therapy. Pediatrics. 1957;19:823–32.
2. Anderson RJ. Hospital associated hyponatremia. Kidney lnt. 1986;29:1237–47.
3. Arieff AI, Ayus JC, Fraser CL, Hyponatraemia and death or permanent brain damage in healthy children. BMJ. 1992;304:1218–22.
4. Halberthal M, Halperin ML, Bohn D. Acute hyponatremia in children admitted in hospital. BMJ. 2001;322:780–2.
5. Holliday MA, Friedman A, Segar ME, Chesney R, Finberg L. Acute hospital induced hyponatremia in children: A physiological approach. J Pediatr. 2004;145:584–7.
6. Montañana PA, Modesto i Alapont V, Ocón AP, López PO, López Prats JL, et al. The use of isotonic fluid as maintenance therapy prevents iatrogenic hyponatremia in pediatrics: A randomized, controlled open study. Pediatr Crit Care Med. 2008;9:658–9.
7. Briassoulis G, Venkataraman S, Thompson AE. Energy expenditure in critically ill children. Pediatr Crit Care Med. 2000;28:1166–72.
8. Choong K, Bohn D. Maintenance parenteral fluids in the critically ill child. J Pediatr (Rio J). 2007; 83:S3–10.
9. Duke T, Mokela D, Frank D, Michael A, Paulo T, Mgone J, et al. Management of meningitis in children with oral fluid restriction or intravenous fluid at maintenance volumes: a randomized trial. Ann Trop Pediatr. 2002;22:145–57.
10. Hoorn EJ, Geary D, Robb M, Halperin ML, Bohn D. Acute hyponatremia related to intravenous fluid administration in hospitalized children: An observational study. Pediatrics. 2004;113:1279–84.
11. Brazel P, McPhee IP. Inappropriate secretion of antidiuretic hormone in postoperative scoliosis patients: The role of fluid management. Spine. 1996;21:727.
12. Neville K, Verge C, Rosenberg A, O’Meara M, Walker J. Isotonic is better than hypotonic saline for intravenous rehydration of children with gastroenteritis: A prospective randomized study. Arch Dis Child. 2006;91:226–32.
13. Kannan L, Lodha R, Vivekanandhan S, Bagga A, Kabra SK, Kabra M. Intravenous fluid regimen and hyponatraemia among children: A randomized controlled trial. Pediatr Nephrol. 2010;25:2303–9.
14. Yung M, Keeley S. Randomised controlled trial of intravenous maintenance fluids. J Paediatr Child Health. 2009;45:9–14.
15. Choong K, Arora S, Cheng J, Farrokhyar F, Reddy D, Thabane L, et al. Hypotonic versus isotonic maintenance fluids after surgery in children: A randomized controlled trial. Pediatrics. 2011;128:857–66.
16. Saba TG, Fairbairn J, Houghton F, Laforte D, Foster BJ. A randomized controlled trial of isotonic versus hypotonic maintenance intravenous fluids in hospitalized children. BMC Pediatr. 2011;11:82.