The impact of obesity on patient survival in liver transplant recipients: A meta-analysis

Liver International

Volumn 35, Issue 1, 2015, Pages 164-170

  Saab, Sammy ^a   Lalezari, David ^b   Pruthi, Paridhima ^a   Alper, Theodore ^a   Tong, Myron J ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KAISER PERMANENTE   (United States)

^c HUNTINGTON MEDICAL RESEARCH INSTITUTES   (United States)

Author keywords

Liver transplantation; Obesity

Indexed keywords

ARTICLE; ASCITES; BODY MASS; BODY WEIGHT; DISEASE SEVERITY; FOLLOW UP; GRAFT RECIPIENT; GRAFT SURVIVAL; HUMAN; LIVER DISEASE; LIVER GRAFT; LIVER TRANSPLANTATION; META ANALYSIS; OBESITY; OUTCOME ASSESSMENT; OVERALL SURVIVAL; RISK FACTOR; SENSITIVITY ANALYSIS; SURGICAL MORTALITY; SYSTEMATIC REVIEW; ADULT; COMPLICATION; MIDDLE AGED; MORTALITY; PATHOLOGY; RISK; STATISTICS AND NUMERICAL DATA; SURVIVAL;

ADULT; ASCITES; BODY MASS INDEX; HUMANS; LIVER TRANSPLANTATION; MIDDLE AGED; OBESITY; RISK; SURVIVAL ANALYSIS; TRANSPLANT RECIPIENTS;

EID: 84921019032     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12431     Document Type: Article

References (36)

1. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity in the United States, 2009-2010. NCHS Data Brief 2012; 82: 1-8.
2. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA 2012; 307: 491-7.
3. Agopian VG, Kaldas FM, Hong JC, et al. Liver transplantation for nonalcoholic steatohepatitis: the new epidemic. Ann Surg 2012; 256: 624-33.
4. Singal AK, Guturu P, Hmoud B, et al. Evolving frequency and outcomes of liver transplantation based on etiology of liver disease. Transplantation 2013; 95: 755-60.
5. Nair S, Verma S, Thuluvath PJ. Obesity and its effect on survival in patients undergoing orthotopic liver transplantation in the United States. Hepatology 2002; 35: 105-9.
6. Zaydfudim V, Feurer ID, Moore DE, et al. The negative effect of pretransplant overweight and obesity on the rate of improvement in physical quality of life after liver transplantation. Surgery 2009; 146: 174-80.
7. Pelletier SJ, Schaubel DE, Wei G, et al. Effect of body mass index on the survival benefit of liver transplantation. Liver Transpl 2007; 13: 1678-83.
8. International Obesity Task Force Secretariat. The Global Challenge of Obesity and the International Obesity Task Force. 2002. Available at [WWW document] URL http://www.iuns.org/the-global-challenge-of-obesity-and-the-international-obesity-task-force. Accessed: 6 August 2013.
9. Charlton MR, Burns JM, Pedersen RA, et al. Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology 2011; 141: 1249-53.
10. Burke A, Lucey MR. Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and orthotopic liver transplantation. Am J Transplant 2004; 4: 686-93.
11. Stepanova M, Younossi ZM. Independent association between nonalcoholic fatty liver disease and cardiovascular disease in the US population. Clin Gastroenterol Hepatol 2012; 10: 646-50.
12. Lazo M, Hernaez R, Eberhardt MS, et al. Prevalence of nonalcoholic Fatty liver disease in the United States: the third national health and nutrition examination survey, 1988-1994. Am J Epidemiol 2013; 178: 38-45.
13. Domanski JP, Park SJ, Harrison SA. Cardiovascular disease and nonalcoholic fatty liver disease: does histologic severity matter? J Clin Gastroenterol 2012; 46: 427-30.
14. Keeffe EB, Gettys C, Esquivel CO. Liver transplantation in patients with severe obesity. Transplantation 1994; 57: 309-11.
15. Hillingsø JG, Wettergren A, Hyoudo M, Kirkegaard P. Obesity increases mortality in liver transplantation - the Danish experience. Transpl Int 2005; 18: 1231-5.
16. Smith SL. Risk factors for premature coronary heart disease after successful liver transplantation in adults. J Transpl Coord 1996; 6: 178-85.
17. Nair S, Cohen DB, Cohen MP, et al. Postoperative morbidity, mortality, costs, and long-term survival in severely obese patients undergoing orthotopic liver transplantation. Am J Gastroenterol 2001; 96: 842-5.
18. Leonard J, Heimbach JK, Malinchoc M, Watt K, Charlton M. The Impact of obesity on long term outcomes in liver transplant recipients - results of the NIDDK liver transplant database. Am J Transplant 2008; 8: 667-672.
19. Boin IF, Almeida LV, Udo EY, et al. Survival analysis of obese patients undergoing liver transplantation. Transplant Proc 2007; 39: 3225-7.
20. Braunfeld MY, Chan S, Pregler J, et al. Liver transplantation in the morbidly obese. J Clin Anesth 1996; 8: 585-90.
21. Dick AA, Spitzer AL, Seifert CF, et al. Liver transplantation at the extremes of the body mass index. Liver Transpl 2009; 15: 968-77.
22. Fujikawa T, Fujita S, Mizuno S, et al. Clinical and financial impact of obesity on the outcome of liver transplantation. Transplant Proc 2006; 38: 3612-4.
23. Hakeem AR, Cockbain AJ, Raza SS, et al. Increased morbidity in overweight and obese liver transplant recipients: a single centre experience of 1325 patients from the United Kingdom. Liver Transpl 2013; 19: 551-62.
24. LaMattina JC, Foley DP, Fernandez LA, et al. Complications associated with liver transplantation in the obese recipient. Clin Transplant 2012; 26: 910-8.
25. Perez-Protto SE, Quintini C, Reynolds LF, et al. Comparable graft and patient survival in lean and obese liver transplant recipients. Liver Transpl 2013; 19: 907-15.
26. Sawyer RG, Pelletier SJ, Pruett TL. Increased early morbidity and mortality with acceptable long-term function in severely obese patients undergoing liver transplantation. Clin Transplant 1999; 13: 126-30.
27. Werneck M, Afonso RC, Coelho GR, et al. Obese and nonobese recipients had similar need for ventilatory support after liver transplantation. Transplant Proc 2011; 43: 165-9.
28. Aytac E, Lavery IC, Kalady MF, Kiran RP. Impact of obesity on operation performed, complications, and long-term outcomes in terms of restoration of intestinal continuity for patients with mid and low rectal cancer. Dis Colon Rectum 2013; 56: 689-97.
29. Donohoe CL, Feeney C, Carey MF, Reynolds JV. Perioperative evaluation of the obese patient. J Clin Anesth 2011; 23: 575-86.
30. Jackson RS, Black JH 3rd, Lum YW, et al. Class I obesity is paradoxically associated with decreased risk of postoperative stroke after carotid endarterectomy. J Vasc Surg 2012; 55: 1306-12.
31. Deugarte DA, Stark R, Kaji AH, et al. Obesity does not impact outcomes for appendicitis. Am Surg 2012; 78: 254-7.
32. Al-Refaie WB, Parsons HM, Henderson WG, et al. Body mass index and major cancer surgery outcomes: lack of association or need for alternative measurements of obesity? Ann Surg Oncol 2010; 17: 2264-73.
33. Charlton M. Obesity, hyperlipidemia, and metabolic syndrome. Liver Transpl 2009; 15(Suppl. 2): S83-9.
34. Desai S, Hong JC, Saab S. Cardiovascular risk factors following orthotopic liver transplantation: predisposing factors, incidence and management. Liver Int 2010; 30: 948-57.
35. Busuttil RW, Farmer DG, Yersiz H, et al. Analysis of long-term outcomes of 3200 liver transplantations over two decades: a single-center experience. Ann Surg 2005; 241: 905-16.
36. Kim WR, Stock PG, Smith JM, et al. OPTN/SRTR 2011 Annual Data Report: liver. Am J Transplant 2013; 13(Suppl. 1): 73-102.