Pharmacokinetics of hydrocodone/acetaminophen combination product in children ages 6-17 with moderate to moderately severe postoperative pain

Journal of Clinical Pharmacology

Volumn 55, Issue 2, 2015, Pages 204-211

  Liu, Wei ^a   Dutta, Sandeep ^a   Kearns, Greg ^b   Awni, Walid ^a   Neville, Kathleen A ^b  

^a ABBVIE INC   (United States)

^b CHILDREN S MERCY HOSPITAL   (United States)

Author keywords

acetaminophen; hydrocodone; Lortab; opioid; pediatric; pharmacokinetics

Indexed keywords

HYDROCODONE; HYDROCODONE BITARTRATE PLUS PARACETAMOL; OPIATE; PARACETAMOL; ACETAMINOPHEN, HYDROCODONE DRUG COMBINATION; DRUG COMBINATION; NARCOTIC ANALGESIC AGENT;

ADOLESCENT; AREA UNDER THE CURVE; ARTICLE; BODY SURFACE; BODY WEIGHT; CHILD; CLINICAL ARTICLE; DRUG CLEARANCE; DRUG DOSE REGIMEN; DRUG EXPOSURE; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; MALE; MULTICENTER STUDY; PAIN SEVERITY; POSTOPERATIVE PAIN; PRESCHOOL CHILD; SINGLE DRUG DOSE; CLINICAL TRIAL; DOSE RESPONSE; DRUG COMBINATION; METABOLISM;

ACETAMINOPHEN; ADOLESCENT; ANALGESICS, OPIOID; AREA UNDER CURVE; BODY SURFACE AREA; BODY WEIGHT; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; FEMALE; HUMANS; HYDROCODONE; MALE; PAIN, POSTOPERATIVE;

EID: 84921000405     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1002/jcph.394     Document Type: Article

References (14)

1. Yaster M, Kost-Byerly S, Maxwell L,. In:, Schechter N, et al. ed., Opioid agonists and antagonists in pediatric pain management in pain in infants, children and adolescents. Philadelphia (PA): Lippincott Williams and Wilkins; 2003: 181-224.
2. Maunuksela EL, Olkkola KT,. Nonsteroidal anti-inflammatory drugs in pediatric pain management. In:, Schechter NL, Berde CB, Yaster M, eds. Pain in infants, children, and adolescents, 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2003: 171-180.
3. Berde CB, Sethna NF,. Analgesics for the treatment of pain in children. NEJM. 2002; 347: 1094-1103.
4. Mather L, Mackie J,. The incidence of postoperative pain in children. Pain. 1983; 15: 271-282.
5. Duedahl TH, Hansen EH,. A qualitative systematic review of morphine treatment in children with postoperative pain. Pediatr Anesth. 2007; 17: 756-774.
6. Koller DM, et al. Effectiveness of oxycodone, ibuprofen, or the combination in the initial management of orthopedic injury-related pain in children. Pediatr Emerg Care. 2007; 23: 627-633.
7. Greco C, Berde C,. Pain management for the hospitalized pediatric patient. Pediatr Clin N Am. 2005; 52: 995-1027.
8. Lortab® Elixir [Package Insert]. Smyrna, GA: UCB Pharma, Inc.; 2008.
9. Bartelink IH, Rademaker CM, Schobben AF, van den Anker JN,. Guidelines on paediatric dosing on the basis of developmental physiology and pharmacokinetic considerations. Clin Pharmacokinet. 2006; 45 (11): 1077-1097.
10. Nimmo WS, Wilson J, Prescott LF,. Narcotic analgesics and delayed gastric emptying during labour. Lancet. 1975; 1 (7912): 890-893.
11. Nimmo WS, Heading RC, Wilson J, Tothill P, Prescott LF,. Inhibition of gastric emptying and drug absorption by narcotic analgesics. Br J Clin Pharmacol. 1975; 2 (6): 509-513.
12. Crawford JD, Terry ME, Rourke GM,. Simplification of drug dosage calculation by application of the surface area principle. Pediatrics. 1850; 5 (5): 783-790.
13. Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE,. Developmental pharmacology-drug disposition, action, and therapy in infants and children. N Engl J Med. 2003; 349: 1157-1167.
14. Hines RN, McCarver DG,. The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes. J Pharmacol Exp Ther. 2002; 300: 355-360.