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Volumn 25, Issue 11, 2014, Pages 2101-2115

The current and future impact of human papillomavirus on treatment of squamous cell carcinoma of the head and neck

Author keywords

Cetuximab; Human papillomavirus; Oropharyngeal cancer; Panitumumab; Squamous cell carcinoma of the head and neck

Indexed keywords

AFATINIB; CARBOPLATIN; CETUXIMAB; CISPLATIN; DACOMITINIB; DOCETAXEL; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; LAPATINIB; NIMORAZOLE; OXALIPLATIN; PACLITAXEL; PANITUMUMAB; PEMETREXED; PLACEBO; SORAFENIB; TIRAPAZAMINE; MONOCLONAL ANTIBODY;

EID: 84921000018     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdu265     Document Type: Review
Times cited : (70)

References (83)
  • 2
    • 77954339808 scopus 로고    scopus 로고
    • Squamous cell carcinoma of the head and neck: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • Gregoire V, Lefebvre JL, Licitra L et al. Squamous cell carcinoma of the head and neck: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010; 21(suppl 5): v184-v186.
    • (2010) Ann Oncol , vol.21 , pp. v184-v186
    • Gregoire, V.1    Lefebvre, J.L.2    Licitra, L.3
  • 4
    • 60549117324 scopus 로고    scopus 로고
    • Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    • Hashibe M, Brennan P, Chuang S et al. Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev 2009; 18: 541-550.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 541-550
    • Hashibe, M.1    Brennan, P.2    Chuang, S.3
  • 5
    • 35648946454 scopus 로고    scopus 로고
    • Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: results of two multicentric casecontrol studies
    • Guha N, Boffetta P, Wunsch Filho V et al. Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: results of two multicentric casecontrol studies. Am J Epidemiol 2007; 166: 1159-1173.
    • (2007) Am J Epidemiol , vol.166 , pp. 1159-1173
    • Guha, N.1    Boffetta, P.2    Wunsch Filho, V.3
  • 6
    • 0034600339 scopus 로고    scopus 로고
    • Evidence for a causal association between human papillomavirus and a subset of head and neck cancers
    • Gillison ML, Koch WM, Capone RB et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 2000; 92: 709-720.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 709-720
    • Gillison, M.L.1    Koch, W.M.2    Capone, R.B.3
  • 8
    • 80052565730 scopus 로고    scopus 로고
    • Human papillomavirus and rising oropharyngeal cancer incidence in the United States
    • Chaturvedi AK, Engels EA, Pfeiffer RM et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 2011; 29: 4294-4301.
    • (2011) J Clin Oncol , vol.29 , pp. 4294-4301
    • Chaturvedi, A.K.1    Engels, E.A.2    Pfeiffer, R.M.3
  • 9
    • 84876062521 scopus 로고    scopus 로고
    • Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer-systematic review and meta-analysis of trends by time and region
    • Mehanna H, Beech T, Nicholson T et al. Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer-systematic review and meta-analysis of trends by time and region. Head Neck 2013; 35: 747-755.
    • (2013) Head Neck , vol.35 , pp. 747-755
    • Mehanna, H.1    Beech, T.2    Nicholson, T.3
  • 10
    • 77950596891 scopus 로고    scopus 로고
    • Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets
    • Hong AM, Grulich AE, Jones D et al. Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets. Vaccine 2010; 28: 3269-3272.
    • (2010) Vaccine , vol.28 , pp. 3269-3272
    • Hong, A.M.1    Grulich, A.E.2    Jones, D.3
  • 11
    • 13944263935 scopus 로고    scopus 로고
    • Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review
    • Kreimer AR, Clifford GM, Boyle P, Franceschi S. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev 2005; 14: 467-475.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 467-475
    • Kreimer, A.R.1    Clifford, G.M.2    Boyle, P.3    Franceschi, S.4
  • 12
    • 34248350674 scopus 로고    scopus 로고
    • Case-control study of human papillomavirus and oropharyngeal cancer
    • D'Souza G, Kreimer AR, Viscidi R et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007; 356: 1944-1956.
    • (2007) N Engl J Med , vol.356 , pp. 1944-1956
    • D'Souza, G.1    Kreimer, A.R.2    Viscidi, R.3
  • 13
    • 66149105905 scopus 로고    scopus 로고
    • Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment
    • Pai SI, Westra WH. Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment. Annu Rev Pathol 2009; 4: 49-70.
    • (2009) Annu Rev Pathol , vol.4 , pp. 49-70
    • Pai, S.I.1    Westra, W.H.2
  • 14
    • 84899121619 scopus 로고    scopus 로고
    • Molecular mechanisms of HPV induced carcinogenesis in head and neck
    • Rampias T, Sasaki C, Psyrri A. Molecular mechanisms of HPV induced carcinogenesis in head and neck. Oral Oncol 2014; 50(5): 356-363.
    • (2014) Oral Oncol , vol.50 , Issue.5 , pp. 356-363
    • Rampias, T.1    Sasaki, C.2    Psyrri, A.3
  • 15
    • 0027358723 scopus 로고
    • The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
    • Scheffner M, Huibregtse JM, Vierstra RD, Howley PM. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 1993; 75: 495-505.
    • (1993) Cell , vol.75 , pp. 495-505
    • Scheffner, M.1    Huibregtse, J.M.2    Vierstra, R.D.3    Howley, P.M.4
  • 16
    • 65349107653 scopus 로고    scopus 로고
    • E6 and E7 gene silencing and transformed phenotype of human papillomavirus 16-positive oropharyngeal cancer cells
    • Rampias T, Sasaki C, Weinberger P, Psyrri A. E6 and E7 gene silencing and transformed phenotype of human papillomavirus 16-positive oropharyngeal cancer cells. J Natl Cancer Inst 2009; 101: 412-423.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 412-423
    • Rampias, T.1    Sasaki, C.2    Weinberger, P.3    Psyrri, A.4
  • 17
    • 0029834371 scopus 로고    scopus 로고
    • E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway
    • Boyer SN, Wazer DE, Band V. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res 1996; 56: 4620-4624.
    • (1996) Cancer Res , vol.56 , pp. 4620-4624
    • Boyer, S.N.1    Wazer, D.E.2    Band, V.3
  • 18
    • 0026609875 scopus 로고
    • Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F
    • Cao L, Faha B, Dembski M et al. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. Nature 1992; 355: 176-179.
    • (1992) Nature , vol.355 , pp. 176-179
    • Cao, L.1    Faha, B.2    Dembski, M.3
  • 19
    • 0024535228 scopus 로고
    • The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
    • Dyson N, Howley PM, Munger K, Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 1989; 243: 934-937.
    • (1989) Science , vol.243 , pp. 934-937
    • Dyson, N.1    Howley, P.M.2    Munger, K.3    Harlow, E.4
  • 20
    • 33644849030 scopus 로고    scopus 로고
    • Molecular classification identifies a subset of human papillomavirus-associated oropharyngeal cancers with favorable prognosis
    • Weinberger PM, Yu Z, Haffty BG et al. Molecular classification identifies a subset of human papillomavirus-associated oropharyngeal cancers with favorable prognosis. J Clin Oncol 2006; 24: 736-747.
    • (2006) J Clin Oncol , vol.24 , pp. 736-747
    • Weinberger, P.M.1    Yu, Z.2    Haffty, B.G.3
  • 21
    • 35948962411 scopus 로고    scopus 로고
    • Gene expression profiles in HPV-infected head and neck cancer
    • Schlecht NF, Burk RD, Adrien L et al. Gene expression profiles in HPV-infected head and neck cancer. J Pathol 2007; 213: 283-293.
    • (2007) J Pathol , vol.213 , pp. 283-293
    • Schlecht, N.F.1    Burk, R.D.2    Adrien, L.3
  • 22
    • 84881219523 scopus 로고    scopus 로고
    • Molecular profile of head and neck squamous cell carcinomas bearing p16 high phenotype
    • Rampias T, Pectasides E, Prasad M et al. Molecular profile of head and neck squamous cell carcinomas bearing p16 high phenotype. Ann Oncol 2013; 24: 2124-2131.
    • (2013) Ann Oncol , vol.24 , pp. 2124-2131
    • Rampias, T.1    Pectasides, E.2    Prasad, M.3
  • 24
    • 74649085290 scopus 로고    scopus 로고
    • Moderate predictive value of demographic and behavioral characteristics for a diagnosis of HPV16-positive and HPV16-negative head and neck cancer
    • D'Souza G, Zhang HH, D'Souza WD et al. Moderate predictive value of demographic and behavioral characteristics for a diagnosis of HPV16-positive and HPV16-negative head and neck cancer. Oral Oncol 2010; 46: 100-104.
    • (2010) Oral Oncol , vol.46 , pp. 100-104
    • D'Souza, G.1    Zhang, H.H.2    D'Souza, W.D.3
  • 25
    • 41449085148 scopus 로고    scopus 로고
    • Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers
    • Gillison ML, D'Souza G, Westra W et al. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 2008; 100: 407-420.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 407-420
    • Gillison, M.L.1    D'Souza, G.2    Westra, W.3
  • 26
    • 43049097865 scopus 로고    scopus 로고
    • Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas
    • Hafkamp HC, Manni JJ, Haesevoets A et al. Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas. Int J Cancer 2008; 122: 2656-2664.
    • (2008) Int J Cancer , vol.122 , pp. 2656-2664
    • Hafkamp, H.C.1    Manni, J.J.2    Haesevoets, A.3
  • 27
    • 84875421186 scopus 로고    scopus 로고
    • Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis
    • O'Sullivan B, Huang SH, Siu LL et al. Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J Clin Oncol 2013; 31: 543-550.
    • (2013) J Clin Oncol , vol.31 , pp. 543-550
    • O'Sullivan, B.1    Huang, S.H.2    Siu, L.L.3
  • 28
    • 77957955293 scopus 로고    scopus 로고
    • Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial
    • Rischin D, Young RJ, Fisher R et al. Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial. J Clin Oncol 2010; 28: 4142-4148.
    • (2010) J Clin Oncol , vol.28 , pp. 4142-4148
    • Rischin, D.1    Young, R.J.2    Fisher, R.3
  • 29
    • 77954600498 scopus 로고    scopus 로고
    • Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology Group
    • Rischin D, Peters LJ, O'Sullivan B et al. Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology Group. J Clin Oncol 2010; 28: 2989-2995.
    • (2010) J Clin Oncol , vol.28 , pp. 2989-2995
    • Rischin, D.1    Peters, L.J.2    O'Sullivan, B.3
  • 30
    • 77954190940 scopus 로고    scopus 로고
    • Human papillomavirus and survival of patients with oropharyngeal cancer
    • Ang KK, Harris J, Wheeler R et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010; 363: 24-35.
    • (2010) N Engl J Med , vol.363 , pp. 24-35
    • Ang, K.K.1    Harris, J.2    Wheeler, R.3
  • 31
    • 84915752148 scopus 로고    scopus 로고
    • Impact of p16 status on the results of the phase III cetuximab (cet)/radiotherapy (RT)
    • Rosenthal DI, Harari PM, Giralt J et al. Impact of p16 status on the results of the phase III cetuximab (cet)/radiotherapy (RT). J Clin Oncol 2014; 32: abstract 6001.
    • (2014) J Clin Oncol , vol.32
    • Rosenthal, D.I.1    Harari, P.M.2    Giralt, J.3
  • 32
    • 79951916067 scopus 로고    scopus 로고
    • Analysis of the effect of p16 and tobacco packyears ( p-y) on overall (OS) and progression-free survival (PFS) for patients with oropharynx cancer (OPC) in Radiation Therapy Oncology Group (RTOG) protocol 9003
    • Gillison ML, Zhang Q, Ang K et al. Analysis of the effect of p16 and tobacco packyears ( p-y) on overall (OS) and progression-free survival (PFS) for patients with oropharynx cancer (OPC) in Radiation Therapy Oncology Group (RTOG) protocol 9003. J Clin Oncol 2010; 28: abstract 5510.
    • (2010) J Clin Oncol , vol.28
    • Gillison, M.L.1    Zhang, Q.2    Ang, K.3
  • 33
    • 18544409287 scopus 로고    scopus 로고
    • A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003
    • Fu KK, Pajak TF, Trotti A et al. A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. Int J Radiat Oncol Biol Phys 2000; 48: 7-16.
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 7-16
    • Fu, K.K.1    Pajak, T.F.2    Trotti, A.3
  • 34
    • 79955514313 scopus 로고    scopus 로고
    • Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial
    • Posner MR, Lorch JH, Goloubeva O et al. Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial. Ann Oncol 2011; 22: 1071-1077.
    • (2011) Ann Oncol , vol.22 , pp. 1071-1077
    • Posner, M.R.1    Lorch, J.H.2    Goloubeva, O.3
  • 35
    • 35548972994 scopus 로고    scopus 로고
    • Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer
    • Posner MR, Hershock DM, Blajman CR et al. Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med 2007; 357: 1705-1715.
    • (2007) N Engl J Med , vol.357 , pp. 1705-1715
    • Posner, M.R.1    Hershock, D.M.2    Blajman, C.R.3
  • 36
    • 65349173893 scopus 로고    scopus 로고
    • Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck
    • Lassen P, Eriksen JG, Hamilton-Dutoit S et al. Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol 2009; 27: 1992-1998.
    • (2009) J Clin Oncol , vol.27 , pp. 1992-1998
    • Lassen, P.1    Eriksen, J.G.2    Hamilton-Dutoit, S.3
  • 37
    • 74549123751 scopus 로고    scopus 로고
    • HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer
    • Lassen P, Eriksen JG, Hamilton-Dutoit S et al. HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer. Radiother Oncol 2010; 94: 30-35.
    • (2010) Radiother Oncol , vol.94 , pp. 30-35
    • Lassen, P.1    Eriksen, J.G.2    Hamilton-Dutoit, S.3
  • 38
    • 0031909654 scopus 로고    scopus 로고
    • A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinom. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85
    • Overgaard J, Sand Hansen H, Overgaard M et al. A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol 1998; 46: 135-146.
    • (1998) Radiother Oncol , vol.46 , pp. 135-146
    • Overgaard, J.1    Sand Hansen, H.2    Overgaard, M.3
  • 39
    • 80053368876 scopus 로고    scopus 로고
    • A randomized phase III trial (RTOG 0522) of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III-IV head and neck squamous cell carcinomas (HNC)
    • Ang KK, Zhang QE, Rosenthal DI et al. A randomized phase III trial (RTOG 0522) of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III-IV head and neck squamous cell carcinomas (HNC). J Clin Oncol 2011; 29: abstract 5500.
    • (2011) J Clin Oncol , vol.29
    • Ang, K.K.1    Zhang, Q.E.2    Rosenthal, D.I.3
  • 40
    • 39649109915 scopus 로고    scopus 로고
    • Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial
    • Fakhry C, Westra WH, Li S et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 2008; 100: 261-269.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 261-269
    • Fakhry, C.1    Westra, W.H.2    Li, S.3
  • 41
    • 84877154549 scopus 로고    scopus 로고
    • Expression of p16, ERCC1, and EGFR amplification as predictors of responsiveness of locally advanced squamous cell carcinomas of head and neck (SCCHN) to cisplatin, radiotherapy, and erlotinib: a phase II randomized trial
    • Austin M, Schmidt R, Parvathaneni U et al. Expression of p16, ERCC1, and EGFR amplification as predictors of responsiveness of locally advanced squamous cell carcinomas of head and neck (SCCHN) to cisplatin, radiotherapy, and erlotinib: a phase II randomized trial. J Clin Oncol 2012; 30: abstract 5515.
    • (2012) J Clin Oncol , vol.30
    • Austin, M.1    Schmidt, R.2    Parvathaneni, U.3
  • 42
    • 84868345415 scopus 로고    scopus 로고
    • A phase II, randomized trial (CONCERT-1) of chemoradiotherapy (CRT) with or without panitumumab (pmab) in patients ( pts) with unresected, locally advanced squamous cell carcinoma of the head and neck (LASCCHN)
    • Giralt J, Fortin A, Mesia R et al. A phase II, randomized trial (CONCERT-1) of chemoradiotherapy (CRT) with or without panitumumab (pmab) in patients ( pts) with unresected, locally advanced squamous cell carcinoma of the head and neck (LASCCHN). J Clin Oncol 2012; 30: abstract 5502.
    • (2012) J Clin Oncol , vol.30
    • Giralt, J.1    Fortin, A.2    Mesia, R.3
  • 43
    • 84888645853 scopus 로고    scopus 로고
    • Phase 2, randomized trial (CONCERT-2) of panitumumab (pmab) plus radiotherapy (PRT) compared with chemoradiotherapy (CRT) in patients ( pts) with unresected, locally advanced squamous cell carcinoma of the head and neck (LASCCHN)
    • Giralt J, Trigo JM, Nuyts S et al. Phase 2, randomized trial (CONCERT-2) of panitumumab (pmab) plus radiotherapy (PRT) compared with chemoradiotherapy (CRT) in patients ( pts) with unresected, locally advanced squamous cell carcinoma of the head and neck (LASCCHN). Ann Oncol 2012; 23: abstract 1016O.
    • (2012) Ann Oncol , vol.23
    • Giralt, J.1    Trigo, J.M.2    Nuyts, S.3
  • 44
    • 84876033745 scopus 로고    scopus 로고
    • Tumor molecular correlates of unresectable, locally advanced head and neck squamous cell carcinoma (SCCHN) response to concurrent radiation (RT), cisplatin (DDP), and cetuximab (C225) in a phase II trial (ECOG 3303)
    • Egloff AM, Lee J, Vaezi AE et al. Tumor molecular correlates of unresectable, locally advanced head and neck squamous cell carcinoma (SCCHN) response to concurrent radiation (RT), cisplatin (DDP), and cetuximab (C225) in a phase II trial (ECOG 3303). J Clin Oncol 2010; 28: abstract 5537.
    • (2010) J Clin Oncol , vol.28
    • Egloff, A.M.1    Lee, J.2    Vaezi, A.E.3
  • 45
    • 84876106601 scopus 로고    scopus 로고
    • Randomised phase II study of oral lapatinib combined with chemoradiotherapy in patients with advanced squamous cell carcinoma of the head and neck: rationale for future randomised trials in human papilloma virus-negative disease
    • Harrington K, Berrier A, Robinson M et al. Randomised phase II study of oral lapatinib combined with chemoradiotherapy in patients with advanced squamous cell carcinoma of the head and neck: rationale for future randomised trials in human papilloma virus-negative disease. Eur J Cancer 2013; 49: 1609-1618.
    • (2013) Eur J Cancer , vol.49 , pp. 1609-1618
    • Harrington, K.1    Berrier, A.2    Robinson, M.3
  • 46
    • 79956159129 scopus 로고    scopus 로고
    • Impact of HPV infection on the clinical outcome of p-CAIR trial in head and neck cancer
    • Snietura M, Piglowski W, Jaworska M et al. Impact of HPV infection on the clinical outcome of p-CAIR trial in head and neck cancer. Eur Arch Otorhinolaryngol 2011; 268: 721-726.
    • (2011) Eur Arch Otorhinolaryngol , vol.268 , pp. 721-726
    • Snietura, M.1    Piglowski, W.2    Jaworska, M.3
  • 47
    • 84856805559 scopus 로고    scopus 로고
    • Phase 2 trial of oxaliplatin and pemetrexed as an induction regimen in locally advanced head and neck cancer
    • Gilbert J, Murphy B, Dietrich MS et al. Phase 2 trial of oxaliplatin and pemetrexed as an induction regimen in locally advanced head and neck cancer. Cancer 2012; 118: 1007-1013.
    • (2012) Cancer , vol.118 , pp. 1007-1013
    • Gilbert, J.1    Murphy, B.2    Dietrich, M.S.3
  • 48
    • 67650079783 scopus 로고    scopus 로고
    • Human papillomavirus infection as a prognostic factor in oropharyngeal squamous cell carcinomas treated in a prospective phase II clinical trial
    • Jo S, Juhasz A, Zhang K et al. Human papillomavirus infection as a prognostic factor in oropharyngeal squamous cell carcinomas treated in a prospective phase II clinical trial. Anticancer Res 2009; 29: 1467-1474.
    • (2009) Anticancer Res , vol.29 , pp. 1467-1474
    • Jo, S.1    Juhasz, A.2    Zhang, K.3
  • 49
    • 73949102962 scopus 로고    scopus 로고
    • Induction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: results from a phase II prospective trial
    • Kies MS, Holsinger FC, Lee JJ et al. Induction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: results from a phase II prospective trial. J Clin Oncol 2010; 28: 8-14.
    • (2010) J Clin Oncol , vol.28 , pp. 8-14
    • Kies, M.S.1    Holsinger, F.C.2    Lee, J.J.3
  • 50
    • 79951861341 scopus 로고    scopus 로고
    • Induction docetaxel, cisplatin, and cetuximab followed by concurrent radiotherapy, cisplatin, and cetuximab and maintenance cetuximab in patients with locally advanced head and neck cancer
    • Argiris A, Heron DE, Smith RP et al. Induction docetaxel, cisplatin, and cetuximab followed by concurrent radiotherapy, cisplatin, and cetuximab and maintenance cetuximab in patients with locally advanced head and neck cancer. J Clin Oncol 2010; 28: 5294-5300.
    • (2010) J Clin Oncol , vol.28 , pp. 5294-5300
    • Argiris, A.1    Heron, D.E.2    Smith, R.P.3
  • 51
    • 84946496958 scopus 로고    scopus 로고
    • Final analysis: a randomized, blinded, placebo (P)-controlled phase III study of adjuvant postoperative lapatinib (L) with concurrent chemotherapy and radiation therapy (CH-RT) in high-risk patients with squamous cell carcinoma of the head and neck (SCCHN)
    • Harrington KJ, Temam S, D'Cruz A et al. Final analysis: a randomized, blinded, placebo (P)-controlled phase III study of adjuvant postoperative lapatinib (L) with concurrent chemotherapy and radiation therapy (CH-RT) in high-risk patients with squamous cell carcinoma of the head and neck (SCCHN). J Clin Oncol 2014; 32: abstract 6005.
    • (2014) J Clin Oncol , vol.32
    • Harrington, K.J.1    Temam, S.2    D'Cruz, A.3
  • 52
    • 84984879477 scopus 로고    scopus 로고
    • Human papillomavirus (HPV) and overall survival (OS) after progression of oropharyngeal squamous cell carcinoma (OPSCC)
    • Fakhry C, Zhang Q, Nguyen-Tan P et al. Human papillomavirus (HPV) and overall survival (OS) after progression of oropharyngeal squamous cell carcinoma (OPSCC). Int J Rad Oncol Biol Phys 2014; 88(2): 466.
    • (2014) Int J Rad Oncol Biol Phys , vol.88 , Issue.2 , pp. 466
    • Fakhry, C.1    Zhang, Q.2    Nguyen-Tan, P.3
  • 53
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamouscell carcinoma of the head and neck
    • Bonner JA, Harari PM, Giralt J et al. Radiotherapy plus cetuximab for squamouscell carcinoma of the head and neck. N Engl J Med 2006; 354: 567-578.
    • (2006) N Engl J Med , vol.354 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3
  • 54
    • 73249143536 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival
    • Bonner JA, Harari PM, Giralt J et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol 2010; 11: 21-28.
    • (2010) Lancet Oncol , vol.11 , pp. 21-28
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3
  • 55
    • 84871463423 scopus 로고    scopus 로고
    • Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer
    • Huang SH, Perez-Ordonez B, Weinreb I et al. Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer. Oral Oncol 2013; 49: 79-85.
    • (2013) Oral Oncol , vol.49 , pp. 79-85
    • Huang, S.H.1    Perez-Ordonez, B.2    Weinreb, I.3
  • 56
    • 35648937953 scopus 로고    scopus 로고
    • A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen
    • Smeets SJ, Hesselink AT, Speel EJ et al. A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen. Int J Cancer 2007; 121(11): 2465-2472.
    • (2007) Int J Cancer , vol.121 , Issue.11 , pp. 2465-2472
    • Smeets, S.J.1    Hesselink, A.T.2    Speel, E.J.3
  • 57
    • 51649085865 scopus 로고    scopus 로고
    • Platinum-based chemotherapy plus cetuximab in head and neck cancer
    • Vermorken JB, Mesia R, Rivera F et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 2008; 359: 1116-1127.
    • (2008) N Engl J Med , vol.359 , pp. 1116-1127
    • Vermorken, J.B.1    Mesia, R.2    Rivera, F.3
  • 58
    • 84892854637 scopus 로고    scopus 로고
    • Safety and efficacy of cisplatin plus 5-FU and cetuximab in HPV-positive and HPV-negative recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): analysis of the phase III EXTREME trial
    • Psyrri A, Licitra L, De Blas B et al. Safety and efficacy of cisplatin plus 5-FU and cetuximab in HPV-positive and HPV-negative recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): analysis of the phase III EXTREME trial. Ann Oncol 2012; 23: abstract 1018O.
    • (2012) Ann Oncol , vol.23
    • Psyrri, A.1    Licitra, L.2    De Blas, B.3
  • 59
    • 85017052694 scopus 로고    scopus 로고
    • EXTREME (PF+/-cetuximab) and SPECTRUM (PF+/-panitumumab): HPV status and outcome
    • Vermorken JB. EXTREME (PF+/-cetuximab) and SPECTRUM (PF+/-panitumumab): HPV status and outcome. Radiother Oncol 2013; 107: abstract SP-006.
    • (2013) Radiother Oncol , vol.107
    • Vermorken, J.B.1
  • 60
    • 84897101976 scopus 로고    scopus 로고
    • Impact of tumor HPV status on outcome in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck receiving chemotherapy with or without cetuximab: retrospective analysis of the phase III EXTREME trial
    • Vermorken JB, Psyrri A, Mesia R et al. Impact of tumor HPV status on outcome in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck receiving chemotherapy with or without cetuximab: retrospective analysis of the phase III EXTREME trial. Ann Oncol 2014; 25(4): 801-807.
    • (2014) Ann Oncol , vol.25 , Issue.4 , pp. 801-807
    • Vermorken, J.B.1    Psyrri, A.2    Mesia, R.3
  • 61
    • 84879785532 scopus 로고    scopus 로고
    • Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamouscell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial
    • Vermorken JB, Stöhlmacher-Williams J, Davidenko I et al. Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamouscell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial. Lancet Oncol 2013; 14: 697-710.
    • (2013) Lancet Oncol , vol.14 , pp. 697-710
    • Vermorken, J.B.1    Stöhlmacher-Williams, J.2    Davidenko, I.3
  • 62
    • 84880709088 scopus 로고    scopus 로고
    • Analysis of HPV and ERCC1 in recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN)
    • Mehra R. Analysis of HPV and ERCC1 in recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). J Clin Oncol 2013; 31: abstract 6006.
    • (2013) J Clin Oncol , vol.31
    • Mehra, R.1
  • 63
    • 84872445077 scopus 로고    scopus 로고
    • A randomized, open-label, phase II study of afatinib (BIBW 2992) versus cetuximab in recurrent or metastatic squamous cell carcinoma of the head and neck-final data
    • Phoenix, AZ
    • Seiwert T, Fayette J, Cupissol D et al. A randomized, open-label, phase II study of afatinib (BIBW 2992) versus cetuximab in recurrent or metastatic squamous cell carcinoma of the head and neck-final data. Multidisciplinary Head and Neck Cancer Symposium, Phoenix, AZ, 2012. Abstract LBPV10.
    • (2012) Multidisciplinary Head and Neck Cancer Symposium
    • Seiwert, T.1    Fayette, J.2    Cupissol, D.3
  • 64
    • 84888064205 scopus 로고    scopus 로고
    • PARTNER: a randomized phase II study of docetaxel/cisplatin (doc/cis) chemotherapy with or without panitumumab ( pmab) as first-line treatment (tx) for recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN)
    • Wirth LJ, Dakhil RS, Kornek G et al. PARTNER: a randomized phase II study of docetaxel/cisplatin (doc/cis) chemotherapy with or without panitumumab ( pmab) as first-line treatment (tx) for recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). J Clin Oncol 2013; 31: abstract 6029.
    • (2013) J Clin Oncol , vol.31
    • Wirth, L.J.1    Dakhil, R.S.2    Kornek, G.3
  • 65
    • 84888056957 scopus 로고    scopus 로고
    • Cetuximab with or without sorafenib in recurrent/metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN)
    • Gilbert J, Schell MJ, Zhao X et al. Cetuximab with or without sorafenib in recurrent/metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN). J Clin Oncol 2013; 31: abstract 6047.
    • (2013) J Clin Oncol , vol.31
    • Gilbert, J.1    Schell, M.J.2    Zhao, X.3
  • 66
    • 84896727505 scopus 로고    scopus 로고
    • Evaluation of potential predictive markers of efficacy of dacomitinib in patients ( pts) with recurrent/metastatic SCCHN from a phase II trial
    • Audet ML, Allo G, Weng X et al. Evaluation of potential predictive markers of efficacy of dacomitinib in patients ( pts) with recurrent/metastatic SCCHN from a phase II trial. J Clin Oncol 2013; 31: abstract 6041.
    • (2013) J Clin Oncol , vol.31
    • Audet, M.L.1    Allo, G.2    Weng, X.3
  • 67
    • 84887122589 scopus 로고    scopus 로고
    • p16 expression as a human papillomavirus (HPV)-independent prognostic biomarker in non-oropharyngeal squamous cell carcinoma (non-OPSCC)
    • Chung CH, Zhang Q, Kong C et al. p16 expression as a human papillomavirus (HPV)-independent prognostic biomarker in non-oropharyngeal squamous cell carcinoma (non-OPSCC). J Clin Oncol 2013; 31: abstract 6007.
    • (2013) J Clin Oncol , vol.31
    • Chung, C.H.1    Zhang, Q.2    Kong, C.3
  • 68
    • 84887076632 scopus 로고    scopus 로고
    • Multimodality determination of HPV status in head and neck cancers (HNC) and development of an HPV signature
    • Zuo Z, Keck MK, Khattri A et al. Multimodality determination of HPV status in head and neck cancers (HNC) and development of an HPV signature. J Clin Oncol 2013; 31: abstract 6008.
    • (2013) J Clin Oncol , vol.31
    • Zuo, Z.1    Keck, M.K.2    Khattri, A.3
  • 69
    • 84902281258 scopus 로고    scopus 로고
    • New treatment strategies for HPV-positive head and neck cancer
    • Kofler B, Laban S, Busch CJ et al. New treatment strategies for HPV-positive head and neck cancer. Eur Arch Otorhinolaryngol 2014; 271: 1861-1867.
    • (2014) Eur Arch Otorhinolaryngol , vol.271 , pp. 1861-1867
    • Kofler, B.1    Laban, S.2    Busch, C.J.3
  • 70
    • 84872324199 scopus 로고    scopus 로고
    • Differential outcome of concurrent radiotherapy plus epidermal growth factor receptor inhibitors versus radiotherapy plus cisplatin in patients with human papillomavirus-related head and neck cancer
    • Pajares B, Trigo JM, Toledo MD et al. Differential outcome of concurrent radiotherapy plus epidermal growth factor receptor inhibitors versus radiotherapy plus cisplatin in patients with human papillomavirus-related head and neck cancer. BMC Cancer 2013; 13: 26.
    • (2013) BMC Cancer , vol.13 , pp. 26
    • Pajares, B.1    Trigo, J.M.2    Toledo, M.D.3
  • 71
    • 84875478416 scopus 로고    scopus 로고
    • Controversies in treatment deintensification of human papillomavirus-associated oropharyngeal carcinomas: should we, how should we, and for whom?
    • Quon H, Forastiere AA. Controversies in treatment deintensification of human papillomavirus-associated oropharyngeal carcinomas: should we, how should we, and for whom? J Clin Oncol 2013; 31: 520-522.
    • (2013) J Clin Oncol , vol.31 , pp. 520-522
    • Quon, H.1    Forastiere, A.A.2
  • 72
    • 84863975396 scopus 로고    scopus 로고
    • Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer
    • Gillison ML, Zhang Q, Jordan R et al. Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer. J Clin Oncol 2012; 30: 2102-2111.
    • (2012) J Clin Oncol , vol.30 , pp. 2102-2111
    • Gillison, M.L.1    Zhang, Q.2    Jordan, R.3
  • 73
    • 84887116228 scopus 로고    scopus 로고
    • Human papillomavirus detection and comorbidity: critical issues in selection of patients with oropharyngeal cancer for treatment De-escalation trials
    • Rietbergen MM, Brakenhoff RH, Bloemena E et al. Human papillomavirus detection and comorbidity: critical issues in selection of patients with oropharyngeal cancer for treatment De-escalation trials. Ann Oncol 2013; 24: 2740-2745.
    • (2013) Ann Oncol , vol.24 , pp. 2740-2745
    • Rietbergen, M.M.1    Brakenhoff, R.H.2    Bloemena, E.3
  • 74
    • 84888074328 scopus 로고    scopus 로고
    • E 1308: a phase II trial of induction chemotherapy (IC) followed by cetuximab with low dose versus standard dose IMRT in patients with human papilloma virus (HPV)-associated resectable squamous cell carcinoma of the oropharynx (OPSCC)
    • Marur S. E 1308: a phase II trial of induction chemotherapy (IC) followed by cetuximab with low dose versus standard dose IMRT in patients with human papilloma virus (HPV)-associated resectable squamous cell carcinoma of the oropharynx (OPSCC). J Clin Oncol 2013; 31: abstract 6005.
    • (2013) J Clin Oncol , vol.31
    • Marur, S.1
  • 76
    • 84984925873 scopus 로고    scopus 로고
    • (13 August 2014, date last accessed)
    • Radiation Therapy Oncology Group. RTOG 1016 protocol information. http://www. rtog.org/ClinicalTrials/ProtocolTable/StudyDetails.aspx?study=1016 2013 (13 August 2014, date last accessed).
    • (2013) RTOG 1016 protocol information
  • 79
    • 84984879447 scopus 로고    scopus 로고
    • (10 July 2014, date last accessed)
    • ClincalTrials.gov. The Quarterback trial. 2013; http://clinicaltrials.gov/ct2/show/NCT01706939 (10 July 2014, date last accessed).
    • (2013) The Quarterback trial
  • 82
    • 84896823075 scopus 로고    scopus 로고
    • Treatment-related outcome of oropharyngeal cancer patients differentiated by HPV dictated risk profile a tertiary cancer centre series analysis
    • Bossi P, Orlandi E, Miceli R et al. Treatment-related outcome of oropharyngeal cancer patients differentiated by HPV dictated risk profile a tertiary cancer centre series analysis. Ann Oncol 2014; 25(3): 694-699.
    • (2014) Ann Oncol , vol.25 , Issue.3 , pp. 694-699
    • Bossi, P.1    Orlandi, E.2    Miceli, R.3


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