Acetaminophen for Patent Ductus Arteriosus

Annals of Pharmacotherapy

Volumn 49, Issue 2, 2015, Pages 241-246

  Le, Jennifer ^a   Gales, Mark A ^a,b   Gales, Barry J ^a,b  

^a SOUTHWESTERN OKLAHOMA STATE UNIVERSITY   (United States)

^b INTEGRIS BAPTIST MEDICAL CENTER   (United States)

Author keywords

acetaminophen; neonates; paracetamol; patent ductus arteriosus

Indexed keywords

IBUPROFEN; PARACETAMOL; PROSTAGLANDIN SYNTHASE INHIBITOR;

DRUG EFFICACY; HUMAN; HYPERTRANSAMINASEMIA; MEDLINE; PATENT DUCTUS ARTERIOSUS; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; TREATMENT DURATION; DUCTUS ARTERIOSUS, PATENT; NEWBORN;

ACETAMINOPHEN; CYCLOOXYGENASE INHIBITORS; DUCTUS ARTERIOSUS, PATENT; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE;

EID: 84920973641     PISSN: 10600280     EISSN: 15426270     Source Type: Journal    
DOI: 10.1177/1060028014557564     Document Type: Review

References (34)

1. US Department of Health & Human Services. National Institutes of Health, National Heart, Lung, and Blood Institute. What is patent ductus arteriosus?http://www.nhl-bi.nih.gov/health/health-topics/topics/pda/. Accessed August 21, 2014.
2. Mayo Clinic. Diseases and conditions: patent ductus arteriosus. http://www.mayoclinic.org/diseases-conditions/patent-ductus-arteriosus/basics/treatment/con-20028530. Accessed August 21, 2014.
3. Sekar KC.Treating patent ductus arteriosus in neonates: evaluating current therapies.Medscape Educ. 2014:1-13
4. Merck Sharp & Dohme Corp. Merck manuals: patent ductus arteriosus (PDA). http://www.merckmanuals.com/professional/pediatrics/congenital_cardiovascular_anomalies/patent_ductus_arteriosus_pda.html?qt=patent%20ductus%20arteriosus&alt=sh%23v1096376. Accessed August 21, 2014.
5. Corff KE,Sekar KC.Clinical considerations for the pharmacological management of patent ductus arteriosus with cyclooxygenase inhibitors in premature infants.J Pediatr Pharmacol Ther. 2007;12:147-157
6. Bose CL,Laughon MM.Patent ductus arteriosus: lack of evidence for common treatments.Arch Dis Child Fetal Neonatal Ed. 2007;92:F498-F502
7. Indocin I.VWhitehouse Station, NJ: Lundbeck Inc; 2009:
8. Lebanon, NJ: Recordati Rare Diseases Inc; 2013:
9. Ohlsson A,Walia R,Shah SS.Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants.Cochrane Database Syst Rev. 2013; (4):
10. Erdeve O,Yurttutan S,Altug N, et al.Oral versus intravenous ibuprofen for patent ductus arteriosus closure: a randomized controlled trial in extremely low birthweight infants.Arch Dis Child Fetal Neonatal Ed. 2012;97:279-283
11. Gokmen T,Erdeve O,Altug N,Oguz SS,Uras N,Dilman U.Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus.J Pediatr. 2011;158:549-554
12. Morris JL,Rosen DA,Rosen KR.Nonsteroidal anti-inflammatory agents in neonates.Paediatr Drugs. 2003;5:385-405
13. 2011. 24th ed.Montvale, NJ: Thompson Reuters; 2011.Montvale, NJ: Thompson Reuters; 2011:
14. Anderson BJ.Paracetamol (acetaminophen): mechanisms of action.Paediatr Anaesth. 2008;18:915-921
15. Hammerman C,Bin-Nun A,Markovitch E,Schimmel MS,Kaplan M,Fink D.Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment.Pediatrics. 2011;128:e1618-e1621
16. Oncel MY,Yurttutan S,Uras N, et al.An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants.Arch Dis Child Fetal Neonatal Ed. 2013;98:F94
17. Jasani B,Kabra N,Nanavati RN.Oral paracetamol in treatment of closure of patent ductus arteriosus in preterm neonates.J Postgrad Med. 2013;59:312-314
18. Ozdemir OM,Dogan M,Kucuktasci K,Ergin H,Sahin O.Paracetamol therapy for patent ductus arteriosus in premature infants: a chance before surgical ligation.Pediatr Cardiol. 2014;35:276-279
19. Sinha R,Negi V,Dalal SS.An interesting observation of PDA closure with oral paracetamol in preterm neonates.J Clin Neonatol. 2013;2:30-32
20. Kessel I,Waisman D,Lavie-Nevo K,Golzman M,Lorber A,Rotschild A.Paracetamol effectiveness, safety and blood level monitoring during patent ductus arteriosus closure: a case series.J Matern Fetal Neonatal Med. 2014;27:1719-1721
21. Nadir E,Kassem E,Foldi S,Hochberg A,Feldman M.Paracetamol treatment of patent ductus arteriosus in preterm infants.J Perinatol. 2014;34:748-749
22. Oncel MY,Yurttutan S,Degirmencioglu H, et al.Intravenous paracetamol treatment in the management of patent ductus arteriosus in extremely low birth weight infants.Neonatology. 2013;103:166-169
23. Alan S,Kahvecioglu D,Erdeve O,Atasay B,Arsan S.Is paracetamol a useful treatment for ibuprofen-resistant patent ductus arteriosus?.Neonatology. 2013;104:168-169
24. Roofthooft DW,van Beynum IM,Helbing WA,Reiss IK,Simons SH.Paracetamol for ductus arteriosus closure: not always a success story.Neonatology. 2013;104:
25. Tekgunduz KS,Ceviz N,Demirelli Y, et al.Intravenous paracetamol for patent ductus arteriosus in premature infants: a lower dose is also effective.Neonatology. 2013;104:6-7
26. Terrin G,Conte F,Scipione A, et al.Efficacy of paracetamol for the treatment of patent ductus arteriosus in preterm neonates.Ital J Pediatr. 2014;40:
27. Yurttutan S,Oncel MY,Arayici S, et al.A different first-choice drug in the medical management of patent ductus arteriosus: oral paracetamol.J Matern Fetal Neonatal Med. 2013;26:825-827
28. Oncel MY,Yurttutan S,Erdeve O, et al.Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: a randomized controlled trial.J Pediatr. 2014;164:510-4
29. DeMauro SB,Wright CJ.Acetaminophen: a possible alternative to ibuprofen in patent ductus arteriosus closure.J Pediatr. 2014;165:207-210
30. Dang D,Wang D,Zhang C,Zhou W,Zhou Q,Wu H.Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: a randomized controlled trial.PLoS One. 2013;8:
31. Zekai Tahir Burak Maternity and Teaching Hospital. Serum level measurement of oral paracetamol and oral ibuprofen for patent ductus arteriosus treatment in preterm infants [NLM identifier: NCT01544972]. http://www.clinicaltrialssearch.org/serum-level-measurement-of-oral-paracetamol-and-oral-ibup-rofen-for-patent-ductus-arteriosus-treatment-in-preterm-infants-nct01544972.html. Accessed October 13, 2014.
32. Hammerman C, Shaare Zedek Medical Center. Paracetamol and patent ductus arteriosus (PDA) [NLM identifier: NCT01291654]. http://clinicaltrials.gov/show/NCT01291654. Accessed October 13, 2014.
33. Aikio O, University of Oulu. The Preterm Infants’ Paracetamol Study (PreParaS) [NLM identifier: NCT01938261]. http://clinicaltrials.gov/show/NCT01938261. Accessed October 13, 2014.
34. LagoP. Paracetamol vs Ibuprofen for PDA Closure in Preterm Infants. (PARIDA) [NLM identifier: NCT02056223]. http://clinicaltrials.gov/ct2/show/NCT02056223. Accessed October 13, 2014.