The role of RIAM in platelets put to a test

Blood

Volumn 125, Issue 2, 2015, Pages 207-208

  Plow, Edward F ^a   Qin, Jun ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; RAP1 GTP INTERACTING ADAPTOR MOLECULE; RAP1 PROTEIN; TALIN; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; RIAM PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL EXPERIMENT; BLOOD CLOTTING; CELL SPREADING; CYTOSKELETON; HEMOSTASIS; HOMOLOGOUS RECOMBINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REVIEW; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; ANIMAL; METABOLISM; PHYSIOLOGY; THROMBOCYTE; THROMBOCYTE ACTIVATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOOD PLATELETS; INTEGRINS; MEMBRANE PROTEINS; PLATELET ACTIVATION;

EID: 84920972680     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-11-608992     Document Type: Review

References (9)

1. Stritt S, Wolf K, Lorenz V, et al. Rap1-GTP-interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice. Blood. 2015;125(2):219-222.
2. Colo GP, Lafuente EM, Teixido J. The MRL proteins: adapting cell adhesion, migration and growth. Eur J Cell Biol. 2012;91(11-12):861-868.
3. Das M, Subbayya Ithychanda S, Qin J, Plow EF. Mechanisms of talin-dependent integrin signaling and crosstalk. Biochim Biophys Acta. 2014;1838(2):579-588.
4. Han J, Lim CJ, Watanabe N, et al. Reconstructing and deconstructing agonist-induced activation of integrin aIIbb3. Curr Biol. 2006;16(18):1796-1806.
5. Lee HS, Lim CJ, Puzon-McLaughlin W, Shattil SJ, Ginsberg MH. RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. J Biol Chem. 2009;284(8):5119-5127.
6. Lafuente EM, van Puijenbroek AA, Krause M, et al. RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev Cell. 2004;7(4):585-595.
7. Goksoy E, Ma YQ, Wang X, et al. Structural basis for the autoinhibition of talin in regulating integrin activation. Mol Cell. 2008;31(1):124-133.
8. Song X, Yang J, Hirbawi J, et al. A novel membranedependent on/off switch mechanism of talin FERM domain at sites of cell adhesion. Cell Res. 2012;22(11): 1533-1545.
9. Chrzanowska-Wodnicka M, Smyth SS, Schoenwaelder SM, Fischer TH, White GC II. Rap1b is required for normal platelet function and hemostasis in mice. J Clin Invest. 2005;115(3):680-687.