Techno-Economic Analysis of Horseradish Peroxidase Production Using a Transient Expression System in Nicotiana benthamiana

Applied Biochemistry and Biotechnology

Volumn 175, Issue 2, 2015, Pages 841-854

  Walwyn, David Richard ^a   Huddy, Suzanne M ^b   Rybicki, Edward P ^b  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Agroinfiltration; Commercial production; Horseradish peroxidase; Nicotiana benthamiana; Techno economic analysis; Transient expression

Indexed keywords

BIOMASS; ENZYMES; FOOD PRODUCTS; MAMMALS; PLANTS (BOTANY); PRODUCTIVITY; RECOMBINANT PROTEINS;

AGROINFILTRATION; COMMERCIAL PRODUCTIONS; HORSE-RADISH PEROXIDASE; NICOTIANA BENTHAMIANA; TECHNO-ECONOMIC ANALYSIS; TRANSIENT EXPRESSION;

ECONOMIC ANALYSIS;

HORSERADISH PEROXIDASE; ISOENZYME; RECOMBINANT ENZYME; RECOMBINANT PROTEIN;

ARTICLE; BIOMASS; CLINICAL ASSESSMENT; COMPARATIVE STUDY; COST BENEFIT ANALYSIS; CROP PRODUCTION; DRUG MANUFACTURE; ECONOMIC ASPECT; ENZYME SYNTHESIS; GREENHOUSE; HUMAN; NICOTIANA BENTHAMIANA; NONHUMAN; PLANT YIELD; PROCESS TECHNOLOGY; SENSITIVITY ANALYSIS; TECHNO ECONOMIC ANALYSIS; TRANSIENT EXPRESSION; BIOSYNTHESIS; BIOTECHNOLOGY; CHEMISTRY; ECONOMICS; ENZYMOLOGY; GENE EXPRESSION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HORSERADISH; ISOLATION AND PURIFICATION; TOBACCO; TRANSGENIC PLANT;

ARMORACIA RUSTICANA; MAMMALIA; NICOTIANA BENTHAMIANA;

ARMORACIA; BIOMASS; BIOTECHNOLOGY; COST-BENEFIT ANALYSIS; GENE EXPRESSION; HORSERADISH PEROXIDASE; ISOENZYMES; PLANTS, GENETICALLY MODIFIED; RECOMBINANT PROTEINS; TOBACCO;

EID: 84920959275     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-014-1320-5     Document Type: Article

References (35)

1. Lico, C., Santi, L., Twyman, R. M., Pezzotti, M., & Avesani, L. (2012). The use of plants for the production of therapeutic human peptides. Plant Cell Reports, 31, 439–451.
2. Viana, A. A., Pelegrini, P. B., & Grossi-de-Sa, M. F. (2012). Plant biofarming: novel insights for peptide expression in heterologous systems. Biopolymers, 98, 416–427.
3. Fischer, R., Drossard, J., Commandeur, U., Schillberg, S., & Emans, N. (1999). Towards molecular farming in the future: moving from diagnostic protein and antibody production in microbes to plants. Biotechnology and Applied Biochemistry, 30(Pt 2), 101–108.
4. Fischer, R., & Emans, N. (2000). Molecular farming of pharmaceutical proteins. Transgenic Research, 9, 279–299.
5. Daniell, H., Singh, N. D., Mason, H., & Streatfield, S. J. (2009). Plant-made vaccine antigens and biopharmaceuticals. Trends in Plant Science, 14, 669–679.
6. Chen, Q., Lai, H., Hurtado, J., Stahnke, J., Leuzinger, K., & Dent, M. (2013). Agroinfiltration as an effective and scalable strategy of gene delivery for production of pharmaceutical proteins. Advanced Techniques in Biology & Medicine, 1, 103. doi:10.4172/atbm.1000103.
7. Gleba, Y. Y., Tusé, D. & Giritch, A. (2014). Plant viral vectors. In K Palmer & Y Gleba, Current topics in microbiology and immunology (pp. 155–192). New York: Springer.
8. Rybicki, E. P. (2010). Plant-made vaccines for humans and animals. Plant Biotechnology Journal, 8, 620–637.
9. Fischer, R., Stoger, E., Schillberg, S., Christou, P., & Twyman, R. M. (2004). Plant-based production of biopharmaceuticals. Current Opinion in Plant Biology, 7, 152–158.
10. Kathuria, S., Sriraman, R., Nath, R., Sack, M., Pal, R., Artsaenko, O., Talwar, G., Fischer, R., & Finnern, R. (2002). Efficacy of plant-produced recombinant antibodies against HCG. Human Reproduction, 17, 2054–2061.
11. Vaquero, C., Sack, M., Schuster, F., Finnern, R., Drossard, J., Schumann, D., Reimann, A., & Fischer, R. (2002). A carcinoembryonic antigen-specific diabody produced in tobacco. The FASEB Journal, 16, 408–410.
12. Meyers, A., Chakauya, E., Shephard, E., Tanzer, F. L., Maclean, J., Lynch, A., Williamson, A.-L., & Rybicki, E. P. (2008). Expression of HIV-1 antigens in plants as potential subunit vaccines. BMC Biotechnology, 8, 53.
13. Maclean, J., Koekemoer, M., Olivier, A., Stewart, D., Hitzeroth, I., Rademacher, T., Fischer, R., Williamson, A.-L., & Rybicki, E. (2007). Optimization of human papilloma virus type 16 (HPV-16) L1 expression in plants: comparison of the suitability of different HPV-16L1 gene variants and different cell-compartment localization. Journal of General Virology, 88, 1460–1469.
14. Ma, J. K., Chikwamba, R., Sparrow, P., Fischer, R., Mahoney, R., & Twyman, R. M. (2005). Plant-derived pharmaceuticals–the road forward. Trends in Plant Science, 10, 580–585.
15. Schillberg, S., Twyman, R. M., & Fischer, R. (2005). Opportunities for recombinant antigen and antibody expression in transgenic plants—technology assessment. Vaccine, 23, 1764–1769.
16. Thomas, D. R., Penney, C. A., Majumder, A., & Walmsley, A. M. (2011). Evolution of plant-made pharmaceuticals. International Journal of Molecular Sciences, 12, 3220–3236.
17. GEN. (2012). Protalix, Pfizer report FDA approval of plant-derived Gaucher disease ERT Elelyso. Genetic Engineering & Biotechnology News. GEN. http://www.genengnews.com/gen-news-highlights/protalix-pfizer-report-fda-approval-of-plant-derived-gaucher-disease-ert-elelyso/81246710/. Accessed 3 April 2014.
18. InVitria. (2010). Lactoferrin is a multi-functional protein that maintains cell health and is found in milk and other bodily fluids. InVitria. http://www.invitria.com/cell-culture-products-services/lactoferrin.html. Accessed 3 April 2014.
19. Spök, A., & Karner, S. (2008). In A. J. Stein & E. Rodríguez-Cerezo (Eds.), Plant molecular farming: opportunities and challenges. Brussels: Institute for Prospective Technological Studies.
20. GEN. (2013). Plant-based protein biomanufacturing. Genetic Engineering & Biotechnology News. GEN. http://www.genengnews.com/gen-articles/plant-based-protein-biomanufacturing/4734/. Accessed 1 August 2014.
21. Buyel, J., & Fischer, R. (2012). Predictive models for transient protein expression in tobacco (Nicotiana tabacum L.) can optimize process time, yield, and downstream costs. Biotechnology and Bioengineering, 109, 2575–2588.
22. Hendricks, F., & Thiel, L. (2011). CSIR biopharming platform: pre-feasibility study report. Pretoria: CSIR.
23. Kushad, M. M., Guidera, M., & Bratsch, A. D. (1999). Distribution of horseradish peroxidase activity in horseradish plants. HortScience, 34, 127–129.
24. Veitch, N. C. (2004). Horseradish peroxidase: a modern view of a classic enzyme. Phytochemistry, 65, 249–259.
25. Krel, H. W. (1991). In J. Lobarzewski, H. Greppin, C. Pelel, & T. Gaspar (Eds.), Biochemical, molecular, and physiological aspects of plant peroxidases (pp. 470–478). Geneva: Imprimerie Nationale.
26. Dewan, S. S. (2011). Market research report on medical enzymes: technologies and global markets. Wellesley: BCC Research.
27. Barnard, A. (2012). The optimization of the extraction and purification of horseradish peroxidase from horseradish roots. MSc Thesis, Stellenbosch University, Stellenbosch, South Africa.
28. Backhurst, J. R., & Harker, J. H. (1973). Process plant design (1st ed.). New York: American Elsevier.
29. Choi, D., Chipman, D. C., Bents, S. C., & Brown, R. C. (2010). A techno-economic analysis of polyhydroxyalkanoate and hydrogen production from syngas fermentation of gasified biomass. Applied Biochemistry and Biotechnology, 160, 1032–1046.
30. Peters, M., Timmerhaus, K. & West, R. (2003). Plant design and economics for chemical engineers. 5th ed. McGraw-Hill Education, New York.
31. Giacomelli, G. (2011). Designing the greenhouse to meet your expectations: what’s your technology level? CEAC, the University of Arizona.
32. Pannell, D. J. (1997). Sensitivity analysis of normative economic models: theoretical framework and practical strategies. Agricultural Economics, 16, 139–152.
33. Estrada, J. M., Kraakman, N., Lebrero, R., & Muñoz, R. (2012). A sensitivity analysis of process design parameters, commodity prices and robustness on the economics of odour abatement technologies. Biotechnology Advances, 30, 1354–1363.
34. de Araujo, A. C., Gallani, S., Mulas, M., & Skogestad, S. (2013). Sensitivity analysis of optimal operation of an activated sludge process model for economic controlled variable selection. Industrial & Engineering Chemistry Research, 52, 9908–9921.
35. Wilken, L. R., & Nikolov, Z. L. (2012). Recovery and purification of plant-made recombinant proteins. Biotechnology Advances, 30, 419–433.