Mucins suppress virulence traits of Candida albicans

mBio

Volumn 5, Issue 6, 2014, Pages

  Kavanaugh, Nicole L ^a,b   Zhang, Angela Q ^a   Nobile, Clarissa J ^c,d   Johnson, Alexander D ^d   Ribbeck, Katharina ^a  

^a Massachusetts Institute of Technology   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUCIN; MUCIN 2; MUCIN 5AC; MUCIN 5B; POLYSTYRENE; VIRULENCE FACTOR;

ARTICLE; BIOFILM; CANDIDA ALBICANS; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; FUNGAL COLONIZATION; FUNGAL GENE; FUNGAL STRUCTURES; FUNGAL VIRULENCE; FUNGUS HYPHAE; GENE EXPRESSION; HOST RESISTANCE; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; YEAST CELL; ANTAGONISTS AND INHIBITORS; CELL ADHESION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PHYSIOLOGY;

CANDIDA ALBICANS;

BIOFILMS; CANDIDA ALBICANS; CELL ADHESION; GENE EXPRESSION REGULATION, FUNGAL; HUMANS; MUCINS; VIRULENCE FACTORS;

EID: 84920896631     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.01911-14     Document Type: Article

References (40)

1. Sudbery P, Gow N, Berman J. 2004. The distinct morphogenic states of Candida albicans. Trends Microbiol. 12:317-324. http://dx.doi.org/10.1016/j.tim.2004.05.008.
2. Calderone RA, Fonzi WA. 2001. Virulence factors of Candida albicans. Trends Microbiol. 9:327-335. http://dx.doi.org/10.1016/S0966-842X(01)02094-7.
3. Donlan RM, Costerton JW. 2002. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin. Microbiol. Rev. 15:167-193. http://dx.doi.org/10.1128/CMR.15.2.167-193.2002.
4. Drell T, Lillsaar T, Tummeleht L, Simm J, Aaspõllu A, Väin E, Saarma I, Salumets A, Donders GG, Metsis M. 2013. Characterization of the vaginal micro-and mycobiome in asymptomatic reproductive-age Estonian women. PLoS One 8:e54379. http://dx.doi.org/10.1371/journal.pone.0054379.
5. Ghannoum MA, Jurevic RJ, Mukherjee PK, Cui F, Sikaroodi M, Naqvi A, Gillevet PM. 2010. Characterization of the oral fungal microbiome (mycobiome) in healthy individuals. PLoS Pathog. 6:e1000713. http://dx.doi.org/10.1371/journal.ppat.1000713.
6. Scanlan PD, Marchesi JR. 2008. Micro-eukaryotic diversity of the human distal gut microbiota: qualitative assessment using culture-dependent and-independent analysis of faeces. ISME J. 2:1183-1193. http://dx.doi.org/10.1038/ismej.2008.76.
7. Lindén SK, Sheng YH, Every AL, Miles KM, Skoog EC, Florin TH, Sutton P, McGuckin MA. 2009. MUC1 Limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy. PLoS Pathog. 5:e1000617. http://dx.doi.org/10.1371/journal.ppat.1000617.
8. Caldara M, Friedlander RS, Kavanaugh NL, Aizenberg J, Foster KR, Ribbeck K. 2012. Mucin biopolymers prevent bacterial aggregation by retaining cells in the free-swimming state. Curr. Biol. 22:2325-2330. http://dx.doi.org/10.1016/j.cub.2012.10.028.
9. Nelson AL, Roche AM, Gould JM, Chim K, Ratner AJ, Weiser JN. 2007. Capsule enhances pneumococcal colonization by limiting mucusmediated clearance. Infect. Immun. 75:83-90. http://dx.doi.org/10.1128/IAI.01475-06.
10. Bergey EJ, Cho MI, Blumberg BM, Hammarskjöld ML, Rekosh D, Epstein LG, Levine MJ. 1994. Interaction of HIV-1 and human salivary mucins. J. Acquir. Immune Defic. Syndr. 7:995-1002.
11. Couceiro JN, Paulson JC, Baum LG. 1993. Influenza virus strains selectively recognize sialyloligosaccharides on human respiratory epithelium; the role of the host cell in selection of hemagglutinin receptor specificity. Virus Res. 29:155-165. http://dx.doi.org/10.1016/0168-1702(93)90056-S.
12. Slutsky B, Staebell M, Anderson J, Risen L, Pfaller M, Soll DR. 1987. “White-opaque transition”: a second high-frequency switching system in Candida albicans. J. Bacteriol. 169:189-197.
13. Kvaal C, Lachke SA, Srikantha T, Daniels K, McCoy J, Soll DR. 1999. Misexpression of the opaque-phase-specific gene PEP1 (SAP1) in the white phase of Candida albicans confers increased virulence in a mouse model of cutaneous infection. Infect. Immun. 67:6652-6662.
14. Anderson JM, Soll DR. 1987. Unique phenotype of opaque cells in the white-opaque transition of Candida albicans. J. Bacteriol. 169:5579-5588.
15. Xie J, Tao L, Nobile CJ, Tong Y, Guan G, Sun Y, Cao C, Hernday AD, Johnson AD, Zhang L, Bai FY, Huang G. 2013. White-opaque switching in natural MTLa/_ isolates of Candida albicans: evolutionary implications for roles in host adaptation, pathogenesis, and sex. PLoS Biol. 11: e1001525. http://dx.doi.org/10.1371/journal.pbio.1001525.
16. Miller MG, Johnson AD. 2002. White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating. Cell 110:293-302. http://dx.doi.org/10.1016/S0092-8674(02)00837-1.
17. Bennett RJ, Uhl MA, Miller MG, Johnson AD. 2003. Identification and characterization of a Candida albicans mating pheromone. Mol. Cell. Biol. 23:8189-8201. http://dx.doi.org/10.1128/MCB.23.22.8189-8201.2003.
18. Hoyer LL, Green CB, Oh SH, Zhao X. 2008. Discovering the secrets of the Candida albicans agglutinin-like sequence (ALS) gene family—a sticky pursuit. Med. Mycol. 46:1-15. http://dx.doi.org/10.1080/13693780701435317.
19. Nobile CJ, Fox EP, Nett JE, Sorrells TR, Mitrovich QM, Hernday AD, Tuch BB, Andes DR, Johnson AD. 2012. A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell 148:126-138. http://dx.doi.org/10.1016/j.cell.2011.10.048.
20. Naglik JR, Challacombe SJ, Hube B. 2003. Candida albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiol. Mol. Biol. Rev. 67:400-428. http://dx.doi.org/10.1128/MMBR.67.3.400-428.2003.
21. Gangloff YG, Romier C, Thuault S, Werten S, Davidson I. 2001. The histone fold is a key structural motif of transcription factor TFIID. Trends Biochem. Sci. 26:250-257. http://dx.doi.org/10.1016/S0968-0004(00)01741-2.
22. Crater JS, Carrier RL. 2010. Barrier properties of gastrointestinal mucus to nanoparticle transport. Macromol. Biosci. 10:1473-1483. http://dx.doi.org/10.1002/mabi.201000137.
23. Kocevar-Nared J, Kristl J, Smid-Korbar J. 1997. Comparative rheological investigation of crude gastric mucin and natural gastric mucus. Biomaterials 18:677-681. http://dx.doi.org/10.1016/S0142-9612(96)00180-9.
24. Worku ML, Sidebotham RL, Baron JH, Misiewicz JJ, Logan RP, Keshavarz T, Karim QN. 1999. Motility of Helicobacter pylori in a viscous environment. Eur. J. Gastroenterol. Hepatol. 11:1143-1150. http://dx.doi.org/10.1097/00042737-199910000-00012.
25. Smith DJ, Gaffney EA, Gadêlha H, Kapur N, Kirkman-Brown JC. 2009. Bend propagation in the flagella of migrating human sperm, and its modulation by viscosity. Cell Motil. Cytoskeleton 66:220-236. http://dx.doi.org/10.1002/cm.20345.
26. Alonso-Monge R, Navarro-García F, Molero G, Diez-Orejas R, Gustin M, Pla J, Sánchez M, Nombela C. 1999. Role of the mitogen-activated protein kinase Hog1p in morphogenesis and virulence of Candida albicans. J. Bacteriol. 181:3058-3068.
27. Banerjee I, Pangule RC, Kane RS. 2011. Antifouling coatings: recent developments in the design of surfaces that prevent fouling by proteins, bacteria, and marine organisms. Adv. Mater. 23:690-718. http://dx.doi.org/10.1002/adma.201001215.
28. Nucci M, Anaissie E. 2001. Revisiting the source of candidemia: skin or gut? Clin. Infect. Dis. 33:1959-1967. http://dx.doi.org/10.1086/323759.
29. Lesuffleur T, Porchet N, Aubert JP, Swallow D, Gum JR, Kim YS, Real FX, Zweibaum A. 1993. Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations. J. Cell Sci. 106 (Pt 3): 771-783.
30. Baillie GS, Douglas LJ. 1999. Role of dimorphism in the development of Candida albicans biofilms. J. Med. Microbiol. 48:671-679. http://dx.doi.org/10.1099/00222615-48-7-671.
31. Ramage G, VandeWalle K, López-Ribot JL, Wickes BL. 2002. The filamentation pathway controlled by the Efg1 regulator protein is required for normal biofilm formation and development in Candida albicans. FEMS Microbiol. Lett. 214:95-100. http://dx.doi.org/10.1111/j.1574-6968.2002.tb11330.x.
32. Ogasawara A, Komaki N, Akai H, Hori K, Watanabe H, Watanabe T, Mikami T, Matsumoto T. 2007. Hyphal formation of Candida albicans is inhibited by salivary mucin. Biol. Pharm. Bull. 30:284-286. http://dx.doi.org/10.1248/bpb.30.284.
33. Butrus SI, Klotz SA.1986. Blocking Candida adherence to contact lenses. Curr. Eye Res. 5:745-750. http://dx.doi.org/10.3109/02713688609000015.
34. Maidan MM, Thevelein JM, Van Dijck P. 2005. Carbon source induced yeast-to-hypha transition in Candida albicans is dependent on the presence of amino acids and on the G-protein-coupled receptor Gpr1. Biochem. Soc. Trans. 33:291-293. http://dx.doi.org/10.1042/BST0330291.
35. Saville SP, Lazzell AL, Monteagudo C, Lopez-Ribot JL. 2003. Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection. Eukaryot. Cell 2:1053-1060. http://dx.doi.org/10.1128/EC.2.5.1053-1060.2003.
36. Staab JF, Bahn Y-S, Sundstrom P. 2003. Integrative, multifunctional plasmids for hypha-specific or constitutive expression of green fluorescent protein in Candida albicans. Microbiology 149(Pt 10):2977-2986. http://dx.doi.org/10.1099/mic.0.26445-0.
37. Lieleg O, Lieleg C, Bloom J, Buck CB, Ribbeck K. 2012. Mucin biopolymers as broad-spectrum antiviral agents. Biomacromolecules 13: 1724-1732. http://dx.doi.org/10.1021/bm3001292.
38. Smith BF, LaMont JT. 1984. Hydrophobic binding properties of bovine gallbladder mucin. J. Biol. Chem. 259:12170-12177.
39. Gong DH, Turner B, Bhaskar KR, LaMont JT. 1990. Lipid binding to gastric mucin: protective effect against oxygen radicals. Am. J. Physiol. 259:G681-G686.
40. Sheffner AL. 1963. The reduction in vitro in viscosity of mucoprotein solutions by a new mucolytic agent, N-acetyl-L-cysteine. Ann. N. Y. Acad. Sci. 106:298-310.