Discovery of novel 2,4-diarylaminopyrimidine analogues (DAAPalogues) showing potent inhibitory activities against both wild-type and mutant ALK kinases

Journal of medicinal chemistry

Volumn 58, Issue 1, 2015, Pages 197-211

  Song, Zilan ^a   Yang, Yanhong ^a   Liu, Zhiqing ^a   Peng, Xia ^a   Guo, Junfeng ^a   Yang, Xinying ^a   Wu, Kui ^a   Ai, Jing ^a   Ding, Jian ^a   Geng, Meiyu ^a   Zhang, Ao ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2-AMINO-N-(3-((5-CHLORO-4-((2-(ISOPROPYLSULFONYL)PHENYL)AMINO)PYRIMIDIN-2-YL)AMINO)PHENYL)ACETAMIDE; ACETANILIDE DERIVATIVE; ANAPLASTIC LYMPHOMA KINASE; ANTINEOPLASTIC AGENT; MUTANT PROTEIN; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; SULFONE;

3T3 CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; AREA UNDER THE CURVE; CELL LINE; CELL PROLIFERATION; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECTS; DRUG SCREENING; FEMALE; GENETICS; HUMAN; METABOLISM; MOUSE; MUTATION; NEOPLASMS; NUDE MOUSE; PATHOLOGY; RAT; TUMOR CELL LINE; TUMOR VOLUME;

ACETANILIDES; ANIMALS; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; FEMALE; HUMANS; MICE; MICE, NUDE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; MUTANT PROTEINS; MUTATION; NEOPLASMS; NIH 3T3 CELLS; PROTEIN KINASE INHIBITORS; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; SULFONES; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84920864868     PISSN: None     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5005144     Document Type: Article

References (0)