메뉴 건너뛰기




Volumn 172, Issue 1, 2015, Pages 64-73

Intense Foxp3+CD25+ regulatory T-cell infiltration is associated with high-grade cutaneous squamous cell carcinoma and counterbalanced by CD8+/Foxp3+CD25+ ratio

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 1; INTERLEUKIN 10; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA;

EID: 84920845127     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.13172     Document Type: Article
Times cited : (31)

References (45)
  • 1
    • 0036241593 scopus 로고    scopus 로고
    • The epidemiology of skin cancer
    • Diepgen TL, Mahler V,. The epidemiology of skin cancer. Br J Dermatol 2002; 146 (Suppl. 61): 1-6.
    • (2002) Br J Dermatol , vol.146 , pp. 1-6
    • Diepgen, T.L.1    Mahler, V.2
  • 2
    • 31444431900 scopus 로고    scopus 로고
    • Non-melanoma skin cancer in Australia: The 2002 national survey and trends since 1985
    • Staples MP, Elwood M, Burton RC, et al,. Non-melanoma skin cancer in Australia: the 2002 national survey and trends since 1985. Med J Aust 2006; 184: 6-10.
    • (2006) Med J Aust , vol.184 , pp. 6-10
    • Staples, M.P.1    Elwood, M.2    Burton, R.C.3
  • 3
    • 79953802502 scopus 로고    scopus 로고
    • The new seventh edition American Joint Committee on Cancer staging of cutaneous non-melanoma skin cancer: A critical review
    • Warner CL, Cockerell CJ,. The new seventh edition American Joint Committee on Cancer staging of cutaneous non-melanoma skin cancer: a critical review. Am J Clin Dermatol 2011; 12: 147-54.
    • (2011) Am J Clin Dermatol , vol.12 , pp. 147-154
    • Warner, C.L.1    Cockerell, C.J.2
  • 4
    • 33645075180 scopus 로고    scopus 로고
    • Cutaneous squamous cell carcinoma: A comprehensive clinicopathologic classification. Part two
    • Cassarino DS, Derienzo DP, Barr RJ,. Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part two. J Cutan Pathol 2006; 33: 261-79.
    • (2006) J Cutan Pathol , vol.33 , pp. 261-279
    • Cassarino, D.S.1    Derienzo, D.P.2    Barr, R.J.3
  • 5
    • 0022447543 scopus 로고
    • Prognostic factors in squamous cell carcinoma of the lower lip
    • Frierson HF Jr, Cooper PH,. Prognostic factors in squamous cell carcinoma of the lower lip. Hum Pathol 1986; 17: 346-54.
    • (1986) Hum Pathol , vol.17 , pp. 346-354
    • Frierson, Jr.H.F.1    Cooper, P.H.2
  • 6
    • 0033946038 scopus 로고    scopus 로고
    • Histologic subtyping and malignancy assessment of cutaneous squamous cell carcinoma
    • Petter G, Haustein UF,. Histologic subtyping and malignancy assessment of cutaneous squamous cell carcinoma. Dermatol Surg 2000; 26: 521-30.
    • (2000) Dermatol Surg , vol.26 , pp. 521-530
    • Petter, G.1    Haustein, U.F.2
  • 7
    • 0035967241 scopus 로고    scopus 로고
    • Cutaneous squamous-cell carcinoma
    • Alam M, Ratner D,. Cutaneous squamous-cell carcinoma. N Engl J Med 2001; 344: 975-83.
    • (2001) N Engl J Med , vol.344 , pp. 975-983
    • Alam, M.1    Ratner, D.2
  • 8
    • 21644472035 scopus 로고    scopus 로고
    • Squamous cell carcinoma of the skin
    • Rudolph R, Zelac DE,. Squamous cell carcinoma of the skin. Plast Reconstr Surg 2004; 114: 82e-94e.
    • (2004) Plast Reconstr Surg , vol.114 , pp. 82e-94e
    • Rudolph, R.1    Zelac, D.E.2
  • 9
    • 33645075180 scopus 로고    scopus 로고
    • Cutaneous squamous cell carcinoma: A comprehensive clinicopathologic classification. Part one
    • Cassarino DS, Derienzo DP, Barr RJ,. Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one. J Cutan Pathol 2006; 33: 191-206.
    • (2006) J Cutan Pathol , vol.33 , pp. 191-206
    • Cassarino, D.S.1    Derienzo, D.P.2    Barr, R.J.3
  • 10
    • 0036657493 scopus 로고    scopus 로고
    • Skin cancer in organ transplant recipients: Epidemiology, pathogenesis, and management
    • Berg D, Otley CC,. Skin cancer in organ transplant recipients: epidemiology, pathogenesis, and management. J Am Acad Dermatol 2002; 47: 1-17.
    • (2002) J Am Acad Dermatol , vol.47 , pp. 1-17
    • Berg, D.1    Otley, C.C.2
  • 11
    • 1942443923 scopus 로고    scopus 로고
    • Histologic features in primary cutaneous squamous cell carcinomas in immunocompromised patients focusing on organ transplant patients
    • Smith KJ, Hamza S, Skelton H,. Histologic features in primary cutaneous squamous cell carcinomas in immunocompromised patients focusing on organ transplant patients. Dermatol Surg 2004; 30: 634-41.
    • (2004) Dermatol Surg , vol.30 , pp. 634-641
    • Smith, K.J.1    Hamza, S.2    Skelton, H.3
  • 12
    • 33646820007 scopus 로고    scopus 로고
    • Subsequent skin cancers in kidney and heart transplant recipients after the first squamous cell carcinoma
    • Euvrard S, Kanitakis J, Decullier E, et al,. Subsequent skin cancers in kidney and heart transplant recipients after the first squamous cell carcinoma. Transplantation 2006; 81: 1093-100.
    • (2006) Transplantation , vol.81 , pp. 1093-1100
    • Euvrard, S.1    Kanitakis, J.2    Decullier, E.3
  • 13
    • 3042786367 scopus 로고    scopus 로고
    • Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin
    • Harwood CA, Surentheran T, Sasieni P, et al,. Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin. Br J Dermatol 2004; 150: 949-57.
    • (2004) Br J Dermatol , vol.150 , pp. 949-957
    • Harwood, C.A.1    Surentheran, T.2    Sasieni, P.3
  • 14
    • 39149086140 scopus 로고    scopus 로고
    • HPV and skin neoplasia
    • (in German)
    • Pfister H,. HPV and skin neoplasia. Hautarzt 2008; 59: 26-30. (in German).
    • (2008) Hautarzt , vol.59 , pp. 26-30
    • Pfister, H.1
  • 15
    • 67349146753 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition induced by keratinocyte growth conditions is overcome by E6 and E7 from HPV16, but not HPV8 and HPV38: Characterization of global transcription profiles
    • Azzimonti B, Dell'Oste V, Borgogna C, et al,. The epithelial-mesenchymal transition induced by keratinocyte growth conditions is overcome by E6 and E7 from HPV16, but not HPV8 and HPV38: characterization of global transcription profiles. Virology 2009; 388: 260-9.
    • (2009) Virology , vol.388 , pp. 260-269
    • Azzimonti, B.1    Dell'Oste, V.2    Borgogna, C.3
  • 16
    • 84872807551 scopus 로고    scopus 로고
    • Relevance of the primary lesion in the prognosis of metastatic cutaneous squamous cell carcinoma
    • Ch'ng S, Clark JR, Brunner M, et al,. Relevance of the primary lesion in the prognosis of metastatic cutaneous squamous cell carcinoma. Head Neck 2013; 35: 190-4.
    • (2013) Head Neck , vol.35 , pp. 190-194
    • Ch'Ng, S.1    Clark, J.R.2    Brunner, M.3
  • 17
    • 84860507700 scopus 로고    scopus 로고
    • T-regulatory cells: Key players in tumor immune escape and angiogenesis
    • Facciabene A, Motz GT, Coukos G,. T-regulatory cells: key players in tumor immune escape and angiogenesis. Cancer Res 2012; 72: 2162-71.
    • (2012) Cancer Res , vol.72 , pp. 2162-2171
    • Facciabene, A.1    Motz, G.T.2    Coukos, G.3
  • 18
    • 14044257121 scopus 로고    scopus 로고
    • Ultraviolet radiation and skin cancer: Molecular mechanisms
    • Hussein MR,. Ultraviolet radiation and skin cancer: molecular mechanisms. J Cutan Pathol 2005; 32: 191-205.
    • (2005) J Cutan Pathol , vol.32 , pp. 191-205
    • Hussein, M.R.1
  • 19
    • 77953621449 scopus 로고    scopus 로고
    • UVR-induced regulatory T cells switch antigen-presenting cells from a stimulatory to a regulatory phenotype
    • Schwarz A, Schwarz T,. UVR-induced regulatory T cells switch antigen-presenting cells from a stimulatory to a regulatory phenotype. J Invest Dermatol 2010; 130: 1914-21.
    • (2010) J Invest Dermatol , vol.130 , pp. 1914-1921
    • Schwarz, A.1    Schwarz, T.2
  • 20
    • 79960835493 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: One-trick ponies or workhorses of the immune system?
    • Reizis B, Colonna M, Trinchieri G, et al,. Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system? Nat Rev Immunol 2011; 11: 558-65.
    • (2011) Nat Rev Immunol , vol.11 , pp. 558-565
    • Reizis, B.1    Colonna, M.2    Trinchieri, G.3
  • 21
    • 35948968823 scopus 로고    scopus 로고
    • Anti-tumor vaccines in head and neck cancer: Targeting immune responses to the tumor
    • Whiteside TL,. Anti-tumor vaccines in head and neck cancer: targeting immune responses to the tumor. Curr Cancer Drug Targets 2007; 7: 633-42.
    • (2007) Curr Cancer Drug Targets , vol.7 , pp. 633-642
    • Whiteside, T.L.1
  • 22
    • 77954721060 scopus 로고    scopus 로고
    • Regulatory T cells in tumor immunity
    • Nishikawa H, Sakaguchi S,. Regulatory T cells in tumor immunity. Int J Cancer 2010; 127: 759-67.
    • (2010) Int J Cancer , vol.127 , pp. 759-767
    • Nishikawa, H.1    Sakaguchi, S.2
  • 23
    • 0141953994 scopus 로고    scopus 로고
    • Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer
    • Hartmann E, Wollenberg B, Rothenfusser S, et al,. Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer. Cancer Res 2003; 63: 6478-87.
    • (2003) Cancer Res , vol.63 , pp. 6478-6487
    • Hartmann, E.1    Wollenberg, B.2    Rothenfusser, S.3
  • 24
    • 77956390779 scopus 로고    scopus 로고
    • In vitro chemosensitivity of head and neck cancer cell lines
    • Schuler PJ, Trellakis S, Greve J, et al,. In vitro chemosensitivity of head and neck cancer cell lines. Eur J Med Res 2010; 15: 337-44.
    • (2010) Eur J Med Res , vol.15 , pp. 337-344
    • Schuler, P.J.1    Trellakis, S.2    Greve, J.3
  • 25
    • 79960021734 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cell subpopulations in head and neck squamous cell carcinoma
    • Thiel A, Kesselring R, Pries R, et al,. Plasmacytoid dendritic cell subpopulations in head and neck squamous cell carcinoma. Oncol Rep 2011; 26: 615-20.
    • (2011) Oncol Rep , vol.26 , pp. 615-620
    • Thiel, A.1    Kesselring, R.2    Pries, R.3
  • 26
    • 84866673992 scopus 로고    scopus 로고
    • High expression of interleukin 10 might predict poor prognosis in early stage oral squamous cell carcinoma patients
    • Chen CJ, Sung WW, Su TC, et al,. High expression of interleukin 10 might predict poor prognosis in early stage oral squamous cell carcinoma patients. Clin Chim Acta 2013; 415: 25-30.
    • (2013) Clin Chim Acta , vol.415 , pp. 25-30
    • Chen, C.J.1    Sung, W.W.2    Su, T.C.3
  • 27
    • 0141926700 scopus 로고    scopus 로고
    • Frequent loss of Fas expression and function in human lung tumours with overexpression of FasL in small cell lung carcinoma
    • Viard-Leveugle I, Veyrenc S, French LE, et al,. Frequent loss of Fas expression and function in human lung tumours with overexpression of FasL in small cell lung carcinoma. J Pathol 2003; 201: 268-77.
    • (2003) J Pathol , vol.201 , pp. 268-277
    • Viard-Leveugle, I.1    Veyrenc, S.2    French, L.E.3
  • 28
    • 1642334157 scopus 로고    scopus 로고
    • Tumor-derived TGF-β modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells
    • Lewis MP, Lygoe KA, Nystrom ML, et al,. Tumor-derived TGF-β modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells. Br J Cancer 2004; 90: 822-32.
    • (2004) Br J Cancer , vol.90 , pp. 822-832
    • Lewis, M.P.1    Lygoe, K.A.2    Nystrom, M.L.3
  • 29
    • 33744457276 scopus 로고    scopus 로고
    • high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers
    • high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers. Cancer Immunol Immunother 2006; 55: 1064-71.
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 1064-1071
    • Kono, K.1    Kawaida, H.2    Takahashi, A.3
  • 30
    • 84871716970 scopus 로고    scopus 로고
    • Basic principles of tumor-associated regulatory T cell biology
    • Savage PA, Malchow S, Leventhal DS,. Basic principles of tumor-associated regulatory T cell biology. Trends Immunol 2013; 34: 33-40.
    • (2013) Trends Immunol , vol.34 , pp. 33-40
    • Savage, P.A.1    Malchow, S.2    Leventhal, D.S.3
  • 31
    • 29444442811 scopus 로고    scopus 로고
    • Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
    • Sato E, Olson SH, Ahn J, et al,. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci USA 2005; 102: 18538-43.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18538-18543
    • Sato, E.1    Olson, S.H.2    Ahn, J.3
  • 32
    • 81555200675 scopus 로고    scopus 로고
    • In breast cancer, a high ratio of tumour-infiltrating intraepithelial CD8+ to FoxP3+ cells is characteristic for the medullary subtype
    • Anz D, Eiber S, Scholz C, et al,. In breast cancer, a high ratio of tumour-infiltrating intraepithelial CD8+ to FoxP3+ cells is characteristic for the medullary subtype. Histopathology 2011; 59: 965-74.
    • (2011) Histopathology , vol.59 , pp. 965-974
    • Anz, D.1    Eiber, S.2    Scholz, C.3
  • 33
    • 79959742164 scopus 로고    scopus 로고
    • Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: The paradox of colorectal cancer
    • Ladoire S, Martin F, Ghiringhelli F,. Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer. Cancer Immunol Immunother 2011; 60: 909-18.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 909-918
    • Ladoire, S.1    Martin, F.2    Ghiringhelli, F.3
  • 34
    • 70350498771 scopus 로고    scopus 로고
    • Colorectal cancer stem cells
    • Salama P, Platell C,. Colorectal cancer stem cells. ANZ J Surg 2009; 79: 697-702.
    • (2009) ANZ J Surg , vol.79 , pp. 697-702
    • Salama, P.1    Platell, C.2
  • 35
    • 68049145110 scopus 로고    scopus 로고
    • Progression of cutaneous squamous cell carcinoma in immunosuppressed patients is associated with reduced CD123+ and FOXP3+ cells in the perineoplastic inflammatory infiltrate
    • Mühleisen B, Petrov I, Gächter T, et al,. Progression of cutaneous squamous cell carcinoma in immunosuppressed patients is associated with reduced CD123+ and FOXP3+ cells in the perineoplastic inflammatory infiltrate. Histopathology 2009; 55: 67-76.
    • (2009) Histopathology , vol.55 , pp. 67-76
    • Mühleisen, B.1    Petrov, I.2    Gächter, T.3
  • 36
    • 77956859589 scopus 로고    scopus 로고
    • FoxP3 expression is increased in cutaneous squamous cell carcinoma with perineural invasion
    • Tallon B, Bhawan J,. FoxP3 expression is increased in cutaneous squamous cell carcinoma with perineural invasion. J Cutan Pathol 2010; 37: 1184-5.
    • (2010) J Cutan Pathol , vol.37 , pp. 1184-1185
    • Tallon, B.1    Bhawan, J.2
  • 37
    • 84875744038 scopus 로고    scopus 로고
    • High tissue density of Foxp3+ T cells is associated with clinical outcome in prostate cancer
    • Flammiger A, Weisbach L, Huland H, et al,. High tissue density of Foxp3+ T cells is associated with clinical outcome in prostate cancer. Eur J Cancer 2013; 49: 1273-9.
    • (2013) Eur J Cancer , vol.49 , pp. 1273-1279
    • Flammiger, A.1    Weisbach, L.2    Huland, H.3
  • 38
    • 79954815112 scopus 로고    scopus 로고
    • An evaluation of the clinical significance of FOXP3+ infiltrating cells in human breast cancer
    • Mahmoud SM, Paish EC, Powe DG, et al,. An evaluation of the clinical significance of FOXP3+ infiltrating cells in human breast cancer. Breast Cancer Res Treat 2011; 127: 99-108.
    • (2011) Breast Cancer Res Treat , vol.127 , pp. 99-108
    • Mahmoud, S.M.1    Paish, E.C.2    Powe, D.G.3
  • 39
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, et al,. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004; 10: 942-9.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3
  • 40
    • 79957884105 scopus 로고    scopus 로고
    • IL-10 expression by primary tumor cells correlates with melanoma progression from radial to vertical growth phase and development of metastatic competence
    • Itakura E, Huang RR, Wen DR, et al,. IL-10 expression by primary tumor cells correlates with melanoma progression from radial to vertical growth phase and development of metastatic competence. Mod Pathol 2011; 24: 801-9.
    • (2011) Mod Pathol , vol.24 , pp. 801-809
    • Itakura, E.1    Huang, R.R.2    Wen, D.R.3
  • 41
    • 47549090432 scopus 로고    scopus 로고
    • TGFβ in Cancer
    • Massaguè J,. TGFβ in Cancer. Cell 2008; 134: 215-30.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massaguè, J.1
  • 42
    • 33646135801 scopus 로고    scopus 로고
    • A novel method for the isolation of skin resident T cells from normal and diseased human skin
    • Clark RA, Chong BF, Mirchandani N, et al,. A novel method for the isolation of skin resident T cells from normal and diseased human skin. J Invest Dermatol 2006; 126: 1059-70.
    • (2006) J Invest Dermatol , vol.126 , pp. 1059-1070
    • Clark, R.A.1    Chong, B.F.2    Mirchandani, N.3
  • 43
    • 34247588130 scopus 로고    scopus 로고
    • CD25+ regulatory T cell inhibition enhances vaccine-induced immunity to neuroblastoma
    • Johnson BD, Jing W, Orentas RJ,. CD25+ regulatory T cell inhibition enhances vaccine-induced immunity to neuroblastoma. J Immunother 2007; 30: 203-14.
    • (2007) J Immunother , vol.30 , pp. 203-214
    • Johnson, B.D.1    Jing, W.2    Orentas, R.J.3
  • 44
    • 34248172651 scopus 로고    scopus 로고
    • CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo
    • Grauer OM, Nierkens S, Bennink E, et al,. CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo. Int J Cancer 2007; 121: 95-105.
    • (2007) Int J Cancer , vol.121 , pp. 95-105
    • Grauer, O.M.1    Nierkens, S.2    Bennink, E.3
  • 45
    • 44349089700 scopus 로고    scopus 로고
    • Treg depletion inhibits efficacy of cancer immunotherapy: Implications for clinical trials
    • Curtin JF, Candolfi M, Fakhouri TM, et al,. Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials. PLoS ONE 2008; 3: e1983.
    • (2008) PLoS ONE , vol.3 , pp. e1983
    • Curtin, J.F.1    Candolfi, M.2    Fakhouri, T.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.