P53 mutations change phosphatidylinositol acyl chain composition

Cell Reports

Volumn 10, Issue 1, 2015, Pages 8-19

  Naguib, Adam ^a   Bencze, Gyula ^a   Engle, Dannielle D ^a   Chio, Iok I C ^a   Herzka, Tali ^a   Watrud, Kaitlin ^a   Bencze, Szilvia ^a   Tuveson, David A ^a   Pappin, Darryl J ^a   Trotman, Lloyd C ^a  

^a Simons Center for Quantitative Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESSENTIAL FATTY ACID; INOSITOL; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; POLYPHOSPHOINOSITIDE; FATTY ACID; PROTEIN P53; PTEN PROTEIN, HUMAN; TP53 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL PHENOMENA; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; FATTY ACID ANALYSIS; FATTY ACID BLOOD LEVEL; LIPID COMPOSITION; LIPID FINGERPRINTING; MASS SPECTROMETRY; MOLECULAR DYNAMICS; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PANCREATIC CANCER CELL LINE; SECOND MESSENGER; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; CELL LINE; GENETICS; HIGH THROUGHPUT SCREENING; HUMAN; ISOLATION AND PURIFICATION; LIPID METABOLISM; METABOLISM; MUTATION; PHOSPHORYLATION;

CELL LINE; FATTY ACIDS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIPID METABOLISM; MUTATION; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORYLATION; PTEN PHOSPHOHYDROLASE; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84920811977     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.12.010     Document Type: Article

References (38)

1. Aoki Y., Hosaka S., Tachibana N., Karasawa Y., Kawa S., Kiyosawa K. Reassessment of K-ras mutations at codon 12 by direct PCR and sequencing from tissue microdissection in human pancreatic adenocarcinomas. Pancreas 2000, 21:152-157.
2. Aoyagi T., Matsui T. Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure. Curr. Pharm. Des. 2011, 17:1818-1824.
3. Balog J., Sasi-Szabó L., Kinross J., Lewis M.R., Muirhead L.J., Veselkov K., Mirnezami R., Dezso B., Damjanovich L., Darzi A., et al. Intraoperative tissue identification using rapid evaporative ionization mass spectrometry. Sci. Transl. Med. 2013, 5:94ra93.
4. Berrozpe G., Schaeffer J., Peinado M., Real F., Perucho M. Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer. Int. J. Cancer 1994, 58:185-191.
5. Bigay J., Antonny B. Curvature, lipid packing, and electrostatics of membrane organelles: defining cellular territories in determining specificity. Dev. Cell 2012, 23:886-895.
6. Caldas C., Hahn S.A., da Costa L.T., Redston M.S., Schutte M., Seymour A.B., Weinstein C.L., Hruban R.H., Yeo C.J., Kern S.E. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat. Genet. 1994, 8:27-32.
7. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-1657.
8. Chen Z., Trotman L.C., Shaffer D., Lin H.-K., Dotan Z.A., Niki M., Koutcher J.A., Scher H.I., Ludwig T., Gerald W., et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 2005, 436:725-730.
9. Clague M.J., Urbé S., de Lartigue J. Phosphoinositides and the endocytic pathway. Exp. Cell Res. 2009, 315:1627-1631.
10. Clark J., Anderson K.E., Juvin V., Smith T.S., Karpe F., Wakelam M.J., Stephens L.R., Hawkins P.T. Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry. Nat. Methods 2011, 8:267-272.
11. Cockcroft S. The diverse functions of phosphatidylinositol transfer proteins. Curr. Top. Microbiol. Immunol. 2012, 362:185-208.
12. Comer F.I., Parent C.A. Phosphoinositides specify polarity during epithelial organ development. Cell 2007, 128:239-240.
13. Courtney K.D., Corcoran R.B., Engelman J.A. The PI3K pathway as drug target in human cancer. J.Clin. Oncol. 2010, 28:1075-1083.
14. Darnell J.C., Osterman D.G., Saltiel A.R. Fatty acid remodelling of phosphatidylinositol under conditions of de novo synthesis in rat liver microsomes. Biochim. Biophys. Acta 1991, 1084:279-291.
15. Feinberg A.P., Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 1983, 301:89-92.
16. Hollander M.C., Blumenthal G.M., Dennis P.A. PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat. Rev. Cancer 2011, 11:289-301.
17. Holthuis J.C., Menon A.K. Lipid landscapes and pipelines in membrane homeostasis. Nature 2014, 510:48-57.
18. Hsu F.F., Turk J. Characterization of phosphatidylinositol, phosphatidylinositol-4-phosphate, and phosphatidylinositol-4,5-bisphosphate by electrospray ionization tandem mass spectrometry: a mechanistic study. J.Am. Soc. Mass Spectrom. 2000, 11:986-999.
19. Hunt A.N., Skippen A.J., Koster G., Postle A.D., Cockcroft S. Acyl chain-based molecular selectivity for HL60 cellular phosphatidylinositol and of phosphatidylcholine by phosphatidylinositol transfer protein alpha. Biochim. Biophys. Acta 2004, 1686:50-60.
20. Ivanova P.T., Milne S.B., Myers D.S., Brown H.A. Lipidomics: a mass spectrometry based systems level analysis of cellular lipids. Curr. Opin. Chem. Biol. 2009, 13:526-531.
21. Kessis T.D., Slebos R.J., Nelson W.G., Kastan M.B., Plunkett B.S., Han S.M., Lorincz A.T., Hedrick L., Cho K.R. Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. Proc. Natl. Acad. Sci. USA 1993, 90:3988-3992.
22. Kita K., Saito S., Morioka C., Watanabe A. Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes. Int. J. Cancer 1999, 80:553-558.
23. Kyriazis A.A., Kyriazis A.P., Sternberg C.N., Sloane N.H., Loveless J.D. Morphological, biological, biochemical, and karyotypic characteristics of human pancreatic ductal adenocarcinoma Capan-2 in tissue culture and the nude mouse. Cancer Res. 1986, 46:5810-5815.
24. Lee C., Kim J.-S., Waldman T. PTEN gene targeting reveals a radiation-induced size checkpoint in human cancer cells. Cancer Res. 2004, 64:6906-6914.
25. Liu Y., Bankaitis V.A. Phosphoinositide phosphatases in cell biology and disease. Prog. Lipid Res. 2010, 49:201-217.
26. Loukopoulos P., Kanetaka K., Takamura M., Shibata T., Sakamoto M., Hirohashi S. Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity. Pancreas 2004, 29:193-203.
27. Milne S.B., Ivanova P.T., DeCamp D., Hsueh R.C., Brown H.A. A targeted mass spectrometric analysis of phosphatidylinositol phosphate species. J.Lipid Res. 2005, 46:1796-1802.
28. Moore P., Sipos B., Orlandini S., Sorio C., Real F., Lemoine N., Gress T., Bassi C., Klöppel G., Kalthoff H., et al. Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. Virchows Arch. 2001, 439:798-802.
29. Moss S.E. How actin gets the PIP. Sci. Signal. 2012, 5:pe7.
30. Park J.Y., Mitrou P.N., Keen J., Dahm C.C., Gay L.J., Luben R.N., McTaggart A., Khaw K.T., Ball R.Y., Arends M.J., Rodwell S.A. Lifestyle factors and p53 mutation patterns in colorectal cancer patients in the EPIC-Norfolk study. Mutagenesis 2010, 25:351-358.
31. Patton G.M., Fasulo J.M., Robins S.J. Separation of phospholipids and individual molecular species of phospholipids by high-performance liquid chromatography. J.Lipid Res. 1982, 23:190-196.
32. Santos C.R., Schulze A. Lipid metabolism in cancer. FEBS J. 2012, 279:2610-2623.
33. Steinberg G., Slaton W.H., Howton D.R., Mead J.F. Metabolism of essential fatty acids. IV. Incorporation of linoleate into arachidonic acid. J.Biol. Chem. 1956, 220:257-264.
34. Tuveson D.A., Hingorani S.R. Ductal pancreatic cancer in humans and mice. Cold Spring Harb. Symp. Quant. Biol. 2005, 70:65-72.
35. Wakelam M.J. The uses and limitations of the analysis of cellular phosphoinositides by lipidomic and imaging methodologies. Biochim. Biophys. Acta 2014, 1841:1102-1107.
36. Wenk M.R., Lucast L., Di Paolo G., Romanelli A.J., Suchy S.F., Nussbaum R.L., Cline G.W., Shulman G.I., McMurray W., De Camilli P. Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry. Nat. Biotechnol. 2003, 21:813-817.
37. Whitman M., Downes C.P., Keeler M., Keller T., Cantley L. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 1988, 332:644-646.
38. Yunis A., Arimura G., Russin D. Human pancreatic carcinoma (MIA PaCa-2) in continuous culture: sensitivity to asparaginase. International journal of cancer 1977, 19:128-135.