Genetic testing in persons with age-related macular degeneration and the use of the AREDS supplements: To test or not to test?

Ophthalmology

Volumn 122, Issue 1, 2015, Pages 212-215

  Chew, Emily Y ^a   Klein, Michael L ^b   Clemons, Traci E ^c   Agrón, Elvira ^a   Abecasis, Gonc¸alo R ^d  

^a NATIONAL EYE INSTITUTE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c EMMES CORPORATION   (United States)

^d UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; PLACEBO; VASCULOTROPIN ANTIBODY; ZINC; ARMS2 PROTEIN, HUMAN; COMPLEMENT FACTOR H; COMPLEMENT FACTOR H, HUMAN; PROTEIN; ZINC DERIVATIVE;

AGE RELATED MACULAR DEGENERATION; ALLELE; ARMS2 GENE; ARTICLE; CFH GENE; CONTROLLED CLINICAL TRIAL (TOPIC); DISEASE COURSE; GENE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SCREENING; GENOTYPE; HUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; RISK REDUCTION; SUPPLEMENTATION; DIETARY SUPPLEMENT; GENETICS; MACULAR DEGENERATION; SINGLE NUCLEOTIDE POLYMORPHISM;

ANTIOXIDANTS; COMPLEMENT FACTOR H; DIETARY SUPPLEMENTS; GENETIC TESTING; GENOTYPE; HUMANS; MACULAR DEGENERATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; ZINC COMPOUNDS;

EID: 84920747114     PISSN: 01616420     EISSN: 15494713     Source Type: Journal    
DOI: 10.1016/j.ophtha.2014.10.012     Document Type: Article

References (5)

1. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled clinical trial of high dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 2001;119:1417-36.
2. Klein ML, Francis PJ, Rosner B, et al. CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration. Ophthalmology 2008;115:1019-25.
3. Awh CC, Lane AM, Hawken S, et al. CFH and ARMS2 genetic polymorphisms predict response to antioxidants and zinc in patients with age-related macular degeneration. Ophthalmology 2013;120:2317-23.
4. Chew EY, Klein M, Clemons TE, et al. No clinically significant association between CFH and ARMS2 genotypes and response to nutritional supplements. AREDS Report Number 38. Ophthalmology 2014;121:2173-80.
5. Awh CC, Hawkin S, Zanke BW. Treatment response to antioxidants and zinc based on CFH and ARMS2 genetic risk allele number in the Age-Related Eye Disease Study. Ophthalmology 2015;122:162-9.