Structure activity relationships of human galactokinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 3, 2015, Pages 721-727

  Liu, Li ^a   Tang, Manshu ^b   Walsh, Martin J ^a,c   Brimacombe, Kyle R ^a   Pragani, Rajan ^a   Tanega, Cordelle ^a   Rohde, Jason M ^a   Baker, Heather L ^a   Fernandez, Elizabeth ^a   Blackman, Burchelle ^a,d   Bougie, James M ^a   Leister, William H ^a   Auld, Douglas S ^a,e   Shen, Min ^a   Lai, Kent ^b   Boxer, Matthew B ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c DOW AGROSCIENCES LLC   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Galactokinase; Galactosemia; Structure activity relationships

Indexed keywords

GALACTOKINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; BENZOXAZOLE DERIVATIVE; GALACTOKINASE; GALACTOSE PHOSPHATE; GALACTOSE-1-PHOSPHATE; PROTEIN BINDING; RECOMBINANT PROTEIN; SPIRO COMPOUND;

ARTICLE; GALACTOSEMIA; HIGH THROUGHPUT SCREENING; HUMAN; IC50; QUANTITATIVE STUDY; STRUCTURE ACTIVITY RELATION; VALIDATION STUDY; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMISTRY; CONFORMATION; GENETICS; KINETICS; LIVER MICROSOME; METABOLISM; MOUSE; RAT; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; BENZOXAZOLES; CRYSTALLOGRAPHY, X-RAY; GALACTOKINASE; GALACTOSEPHOSPHATES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; KINETICS; MICE; MICROSOMES, LIVER; MOLECULAR CONFORMATION; PROTEIN BINDING; RATS; RECOMBINANT PROTEINS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84920734805     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.11.061     Document Type: Article

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