Fecal microbiota transplantation via nasogastric tube for recurrent clostridium difficile infection in pediatric patients

Journal of Pediatric Gastroenterology and Nutrition

Volumn 60, Issue 1, 2015, Pages 23-26

  Kronman, Matthew P ^a   Nielson, Heather J ^b   Adler, Amanda L ^b   Giefer, Matthew J ^a   Wahbeh, Ghassan ^a   Singh, Namita ^a   Zerr, Danielle M ^a   Suskind, David L ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b SEATTLE CHILDREN S HOSPITAL   (United States)

Author keywords

Clostridium difficile; fecal microbiota transplantation; pediatrics

Indexed keywords

ADOLESCENT; ARTICLE; BIOLOGICAL THERAPY; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CLOSTRIDIUM DIFFICILE INFECTION; DIARRHEA; FECAL MICROBIOTA TRANSPLANTATION; FECES MICROFLORA; FEMALE; FOLLOW UP; HUMAN; MALE; NASOGASTRIC TUBE; PEDIATRIC RECURRENT CLOSTRIDIUM DIFFICILE INFECTION; PRESCHOOL CHILD; PRIORITY JOURNAL; RECURRENT INFECTION; RELAPSE; RETROSPECTIVE STUDY; SCHOOL CHILD; TREATMENT OUTCOME; VOMITING; ADVERSE EFFECTS; CHILD, PRESCHOOL; CLOSTRIDIUM DIFFICILE; COMORBIDITY; DONOR SELECTION; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FECES; FOLLOW-UP STUDIES; GROWTH AND DEVELOPMENT; HOSPITALS, PEDIATRIC; HUMANS; IMMUNOCOMPROMISED HOST; IMMUNOLOGY; INTUBATION, GASTROINTESTINAL; ISOLATION AND PURIFICATION; MICROBIOLOGY; MICROBIOTA; RECURRENCE; RETROSPECTIVE STUDIES; THERAPIES, INVESTIGATIONAL; WASHINGTON;

CLOSTRIDIUM DIFFICILE;

CHILD; CHILD, PRESCHOOL; CLOSTRIDIUM DIFFICILE; COMORBIDITY; DONOR SELECTION; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FECES; FEMALE; FOLLOW-UP STUDIES; HOSPITALS, PEDIATRIC; HUMANS; IMMUNOCOMPROMISED HOST; INTUBATION, GASTROINTESTINAL; MALE; MICROBIOTA; RECURRENCE; RETROSPECTIVE STUDIES; THERAPIES, INVESTIGATIONAL; WASHINGTON;

EID: 84920719752     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0000000000000545     Document Type: Article

References (15)

1. Aas J, Gessert CE, Bakken JS. Recurrent Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube. Clin Infect Dis 2003;36:580-5.
2. Khoruts A, Dicksved J, Jansson JK, et al. Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-Associated diarrhea. J Clin Gastroenterol 2010;44:354-60.
3. Rohlke F, Surawicz CM, Stollman N. Fecal flora reconstitution for recurrent Clostridium difficile infection: results and methodology. J Clin Gastroenterol 2010;44:567-70.
4. Garborg K, Waagsbo B, Stallemo A, et al. Results of faecal donor instillation therapy for recurrent Clostridium difficile-Associated diarrhoea. Scand J Infect Dis 2010;42:857-61.
5. Gough E, Shaikh H, Manges AR. Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection. Clin Infect Dis 2011;53:994-1002.
6. van Nood E, Vrieze A, Nieuwdorp M, et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 2013;368:407-15.
7. Youngster I, Sauk J, Pindar C, et al. Fecal microbiota transplant for relapsing Clostridium difficile infection using a frozen inoculum from unrelated donors: a randomized, open-label, controlled pilot study. Clin Infect Dis 2014;58:1515-22.
8. Russell G, Kaplan J, Ferraro M, et al. Fecal bacteriotherapy for relapsing Clostridium difficile infection in a child: a proposed treatment protocol. Pediatrics 2010;126:e239-42.
9. Kahn SA, Young S, Rubin DT. Colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection in a child. Am J Gastroenterol 2012;107:1930-1.
10. Russell GH, Kaplan JL, Youngster I, et al. Fecal transplant for recurrent Clostridium difficile infection in children with and without inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2014;58:588-92.
11. Pierog A, Mencin A, Reilly NR. Fecal microbiota transplantation in children with recurrent Clostridium difficile infection. Pediatr Infect Dis J 2014.
12. Brecher SM, Novak-Weekley SM, Nagy E. Laboratory diagnosis of Clostridium difficile infections: there is light at the end of the colon. Clin Infect Dis 2013;57:1175-81.
13. US Food and Drug Administration/American Association of Blood Banks. Donor history questionnaire. http://www.fda.gov/biologics bloodvaccines/bloodbloodproducts/approvedproducts/licensedproducts blas/blooddonorscreening/ucm164185.htm. Accessed December 1,2014.
14. Bakken JS, Borody T, Brandt LJ, et al. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol 2011;9:1044-9.
15. Zipursky JS, Sidorsky TI, Freedman CA, et al. Patient attitudes toward the use of fecal microbiota transplantation in the treatment of recurrent Clostridium difficile infection. Clin Infect Dis 2012;55:1652-8.