Quantification of major compounds from Ixeris dentata, Ixeris dentata Var. albiflora, and Ixeris sonchifolia and their comparative anti-inflammatory activity in Lipopolysaccharide-Stimulated RAW 264.7 Cells

Journal of Medicinal Food

Volumn 18, Issue 1, 2015, Pages 83-94

  Karki, Subash ^a   Park, Hee Juhn ^b   Nugroho, Agung ^b   Kim, Eon Ji ^a   Jung, Hyun Ah ^c   Choi, Jae Sue ^a  

^a Pukyong National University   (South Korea)

^b Sangji University   (South Korea)

^c Chonbuk National University   (South Korea)

Author keywords

anti inflammatory; HPLC; Ixeris dentata; Ixeris dentata var. albiflora; Ixeris sonchifolia; luteolin 7 O glucoside; luteolin 7 O glucuronide; nitric oxide

Indexed keywords

ANTIINFLAMMATORY AGENT; BACTERIUM LIPOPOLYSACCHARIDE; CAFFEIC ACID; CHLOROGENIC ACID; CYCLOOXYGENASE 2 INHIBITOR; INOSINATE DEHYDROGENASE; IXERIS ALBIFLORA EXTRACT; IXERIS DENTATA EXTRACT; IXERIS SONCHIFOLIA EXTRACT; LUTEOLIN; LUTEOLIN 7 O BETA DEXTRO GLUCOPYRANOSIDE; LUTEOLIN 7 O GLUROSIDE; NITRIC OXIDE; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; TROLOX C; UNCLASSIFIED DRUG; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; POLYPHENOL;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; CELL VIABILITY ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IC50; IXERIS ALBIFLORA; IXERIS DENTATA; IXERIS SONCHIFOLIA; LIMIT OF QUANTITATION; METABOLITE; MOUSE; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; THIN LAYER CHROMATOGRAPHY; TRADITIONAL MEDICINE; WESTERN BLOTTING; ANIMAL; ASTERACEAE; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; INFLAMMATION; MACROPHAGE; METABOLISM; PHYTOTHERAPY;

IXERIS DENTATA; IXERIS DENTATA VAR. ALBIFLORA; IXERIS SONCHIFOLIA; MURINAE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTERACEAE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOXYGENASE 2; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHYTOTHERAPY; PLANT EXTRACTS; POLYPHENOLS; REACTIVE OXYGEN SPECIES;

EID: 84920719096     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2014.3205     Document Type: Article

References (44)

1. Zhong Y: Great Dictionary of Chinese Medicinals. Vol. 1. Shanghai Science and Technological Publisher, Shanghai, China, 1985, pp. 589-597.
2. Zhang YC, He CN, Chew EH: Studies on the chemical constituents and biological activities of Ixeris. Chem Biodivers 2013;10:1373-1391.
3. Ahn EM, Bang MH, Song MC, et al.: Cytotoxic and ACAT inhibitory sesquiterpene lactones from the root of Ixeris dentata forma. albiflora. Arch Pharm Res 2006;29:937-941.
4. Park EK, Sung JH, Trinh HT, et al.: Lactic acid bacterial fermentation increases the antiallergic effects of Ixeris dentata. J Microbiol Biotechnol 2008;18:308-313.
5. Seto M, Miyasa T, Fukushima S: Sesquiterpene lactones from Ixeris dentata Nakai. Chem Pharm Bull 1986;34: 4170-4176.
6. Choi JS, Young HS, Kim BW: Hyperglycemic and hyperlipemic effects of Ixeris dentata in diabetic rats. Arch Pharm Res 1990;13:269-273.
7. Hong S, Jeong D, Kim K, Hwang E: The composition of the root of Ixeris dentata var. albiflora Nakai and cell viability and DPPH radical scavenging activities of its extract. Korean J Nutr 2010;43:105-113.
8. Kim DS, Ko JH, Jeon YD, et al.: Ixeris dentata Nakai reduces clinical score and HIF-1expression in experimental colitis in mice. Evid Based Complement Alternat Med 2013:2013;671281.
9. Ye G, Fang JJ, Fan MS, Huang CG: Structure elucidation and complete NMR spectral assignments of a novel sesquiterpene glycoside from Ixeris sonchifolia. Magn Reson Chem 2007;45: 362-363.
10. Huang HM: Clinical efficiency evaluation of Kudiezi injection on treating 65 cerebral infarction patients. Chin J Tradit Med Sci Technol 2008;15:389.
11. Wang LZ: Clinical observation on the effect of Ixeris Sonchifolia Hance injection on the treatment of 40 angina pectoris of coronary heart disease phlegm obstruction patients. Yunnan J Tradit Chin Med Mater Med 2008;29:6-8.
12. Shi P, Zhang Y, Qu H, Fan X: Systematic characterisation of secondary metabolites from Ixeris sonchifolia by the combined use of HPLC-TOFMS and HPLC-ITMS. Phytochem Anal 2011;22:66-73.
13. Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE: Chronic inflammation: importance of NOD2 and NALP3 in interleukin- 1beta generation. Clin Exp Immunol 2007;147:227-235.
14. Heiss E, Herhaus C, Klimo K, Bartsch H, Gerhauser C: Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem 2001;276:32008-32015.
15. Garcia-Lafuente A, Guillamon E, Villares A, Rostagno MA, Martinez JA: Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res 2009;58: 537-552.
16. Petros A, Bennett D, Vallance P: Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 1991;338:1557-1558.
17. Ju HK, Baek SH, An RB, et al.: Inhibitory effects of nardostachin on nitric oxide, prostaglandin E2, and tumor necrosis factor-A production in lipopolysaccharide activated macrophages. Biol Pharm Bull 2003;26:1375-1378.
18. Brock TG, McNish RW, Peters-Golden M: Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2. J Biol Chem 1991;274:11660-11666.
19. Kong LY, Zhang L, Yu ZG, Yuan L: RP-HPLC determination of adenosine in herb of Ixeris sonchifolia (Bge.) Hance. Chin J Pharm Anal 2006;26:1665-1667.
20. Yin R, Deng XX, Han F, et al.: Determination of five components in Ixeris sonchifolia by high performance liquid chromatography. J Pharm Biomed Anal 2007;43:1364-1369.
21. Sun Q, Chang L, Ren Y, et al.: Simultaneous analysis of 11 main active components in Cirsium setosum based on HPLC-ESI-MS/MS and combinedwith statistical methods. JSepSci 2012;35:2897-2907.
22. Ainsworth EA, Gillespie KM: Estimation of total phenolic content and other oxidation substrates in plant tissues using Folin- Ciocalteu reagent. Nat Protoc 2007;2:875-877.
23. Mossman T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J Immunol Methods 1983;65:55-63.
24. Shin EM, Zhou HY, Guo LY, et al.: Anti-inflammatory effects of glycyrol isolated from Glycyrrhiza uralensis in LPS-stimulated RAW 264.7 macrophages. Int Immunopharmacol 2008;8:1524-1532.
25. Lebel CP, Bondy SC: Sensitive and rapid quantitation of oxygen reactive species formation in rat synaptosomes. Neurochem Int 1990;17:435-440.
26. Sharif O, Bolshakov VN, Raines S, Newham P, Perkins ND: Transcriptional profiling of the LPS induced NF-jB response in macrophages. BMC Immunol 2007;8:1-17.
27. Lee HY, Lee GH, Kim HK, et al.: Ixeris dentata induced regulation of amylase synthesis and secretion in glucose-treated human salivary gland cells. Food Chem Toxicol 2013;62:739-749.
28. Chung HS, Jeong HJ, Han MJ, et al.: Nitric oxide and tumor necrosis factor-A production by Ixeris dentata in mouse peritoneal macrophages. J Ethnopharmacol 2002;82:217-222.
29. Lee E: Effects of Ixeris dentata extract on the production of proinflammatory cytokines in the LPS stimulated rat and Raw 264.7 cells. Korean J Plant Res 2011;24:604-612.
30. Nugroho A, Kim MH, Lee CM, Choi JS, Lee S, Park HJ: Highperformance liquid chromatographic quantification and validation of luteolin glycosides from Sonchus brachyotus and their peroxynitrite-scavenging activity. Nat Pro Sci 2012;18:39-46
31. Husain SR, Cillard J, Cillard P: Hydroxyl radical scavenging activity of flavonoids. Phytochem 1989;26:2489-2491.
32. Rice-Evans CA, Miller NJ, Paganga G: Antioxidant properties of phenolic compounds. Trends Plant Sci 1997;2:152-159.
33. Valko M: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell 2007;39:44-84.
34. Shan J, Fu J, Zhao Z, et al.: Chlorogenic acid inhibits lipopolysaccharide- induced cyclooxygenase-2 expression in RAW 264.7 cells through suppressing NF-jB and JNK/AP-1 activation. Int Immunopharmacol 2009;9:1042-1048.
35. Francisco V, Costa G, Figueirinha A, et al.: Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-kappaB pathway inhibition: contribution of chlorogenic acid. J Ethnopharmacol 2013;148:126-134
36. Kwon SH, Lee HK, Kim JA, et al.: Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via antiacetylcholinesterase and anti-oxidative activities in mice. Eur J Pharmacol 2010;649:210-217.
37. Park KH, Park M, Choi SE, et al.: The anti-oxidative and antiinflammatory effects of caffeoyl derivatives from the roots of Aconitum koreanum R. Raymond. Biol Pharm Bull 2009;32:2029-2033.
38. Huang SS, Chiu CS, Lin TH, et al.: Antioxidant and anti-inflammatory activities of aqueous extract of Centipeda minima. J Ethnopharmacol 2013;147:395-405.
39. Jung HA, Jin SE, Min BS, Kim BW, Choi JS: Anti-inflammatory activity of Korean thistle Cirsium maackii and its major flavonoid, luteolin 5-O-glucoside. Food Chem Toxicol 2012;50:2171-2179.
40. Nishitani Y, Yamamoto K, Yoshida M, et al.: Intestinal antiinflammatory activity of luteolin: role of the aglycone in NFkappaB inactivation in macrophages co-cultured with intestinal epithelial cells. BioFactors 2013;39:522-533.
41. Park CM, Song YS: Luteolin and luteolin-7-O-glucoside inhibit lipopolysaccharide-induced inflammatory responses through modulation of NF-jB/AP-1/PI3K-Akt signaling cascades in RAW 264.7 cells. Nutr Res Pract 2013;7:423-429.
42. Hu C, Kitts DD: Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW 264.7 cells. Mol Cell Biochem 2004;265:107-113.
43. Quillet-Mary A, Jaffrezou JP, Mansat V, Bordier C, Naval J, Laurent G: Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. J Biol Chem 1997;272: 21388-21395.
44. Heim KE, Tagliaferro AR, Bobilya DJ: Flavonoid antioxidants: chemistry, metabolism and structure-Activity relationships. J Nutr Biochem 2002;13:572-584.