MiR-23a/-24-induced gene silencing results in mesothelial cell integration of pancreatic cancer

British Journal of Cancer

Volumn 112, Issue 1, 2015, Pages 131-139

  Listing, H ^a   Mardin, W A ^a   Wohlfromm, S ^b   Mees, S T ^a   Haier, J ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b Arrows Biomedical Deutschland GmbH   (Germany)

Author keywords

EMT; FZD5; HNF1B; miR 23a; miR 24; PDAC; peritoneal dissemination; TMEM92

Indexed keywords

BETA CATENIN; ELONGATION FACTOR; FZD5 PROTEIN; HEPATOCYTE NUCLEAR FACTOR 1BETA; MICRORNA; MICRORNA 23A; MICRORNA 24; TMEM92 PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN; MIRN23 MICRORNA, HUMAN; MIRN24 MICRORNA, HUMAN;

ARTICLE; CELL ADHESION ASSAY; CELL INTERACTION; CELL MIGRATION ASSAY; CONTROLLED STUDY; DISTANT METASTASIS; GENE EXPRESSION PROFILING; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; MESOTHELIUM CELL; MICROARRAY ANALYSIS; PANCREAS ADENOCARCINOMA; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME-LAPSE VIDEO MICROSCOPY; TUMOR INVASION; WESTERN BLOTTING; BIOSYNTHESIS; CELL COMMUNICATION; EPITHELIUM; GENETICS; METABOLISM; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; TISSUE MICROARRAY; TUMOR CELL LINE;

CARCINOMA, PANCREATIC DUCTAL; CELL COMMUNICATION; CELL LINE, TUMOR; EPITHELIUM; GENE SILENCING; HUMANS; MICRORNAS; PANCREATIC NEOPLASMS; TISSUE ARRAY ANALYSIS;

EID: 84920671215     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2014.587     Document Type: Article

References (29)

1. Bhanot P, Brink M, Samos CH, Hsieh JC, Wang Y, Macke JP, Andrew D, Nathans J, Nusse R (1996) A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382: 225-230.
2. Bloomston M, Frankel WL, Petrocca F, Volinia S, Alder H, Hagan JP, Liu CG, Bhatt D, Taccioli C, Croce CM (2007) MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA 297: 1901-1908.
3. Brown AM, Wildin RS, Prendergast TJ, Varmus HE (1986) A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line. Cell 46: 1001-1009.
4. Bu XM, Zhao CH, Zhang N, Gao F, Lin S, Dai XW (2008) Hypermethylation and aberrant expression of secreted frizzled-related protein genes in pancreatic cancer. World J Gastroenterol 14: 3421-3424.
5. Bushati N, Cohen SM (2007) MicroRNA functions. Annu Rev Cell Dev Biol 23: 175-205.
6. Clevers H, Nusse R (2012) Wnt/b-catenin signaling and disease. Cell 149: 1192-1205.
7. Goomer RS, Holst BD, Wood IC, Jones FS, Edelman GM (1994) Regulation in vitro of an L-CAM enhancer by homeobox genes HoxD9 and HNF-1. Proc Natl Acad Sci USA 91: 7985-7989.
8. Howard S, Deroo T, Fujita Y, Itasaki N (2011) A positive role of cadherin in Wnt/β-catenin signalling during epithelial-mesenchymal transition. PLoS One 6: e23899.
9. Jamora C, DasGupta R, Kocieniewski P, Fuchs E (2003) Links between signal transduction, transcription and adhesion in epithelial bud development. Nature 422: 317-322.
10. Jang JY, Kang MJ, Heo JS, Choi SH, Choi DW, Park SJ, Han SS, Yoon DS, Yu HC, Kang KJ, Kim SG, Kim SW (2013) A prospective randomized controlled study comparing outcomes of standard resection and extended resection, including dissection of the nerve plexus and various lymph nodes, in patients with pancreatic head cancer. Ann Surg 259(4): 656-664.
11. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ (2009) Cancer statistics, 2009. CA Cancer J Clin 59: 225-249.
12. Konstas AA, Shearwin-Whyatt LM, Fotia AB, Degger B, Riccardi D, Cook DI, Korbmacher C, Kumar S (2002) Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein. J Biol Chem 277: 29406-29416.
13. Lee EJ, Gusev Y, Jiang J, Nuovo GJ, Lerner MR, FrankelWL, Morgan DL, Postier RG, Brackett DJ, Schmittgen TD (2007) Expression profiling identifies microRNA signature in pancreatic cancer. Int J Cancer 120: 1046-1054.
14. Lim J, Thiery JP (2012) Epithelial-mesenchymal transitions: insights from development. Development 139: 3471-3486.
15. McCleary-Wheeler AL, Lomberk GA, Weiss FU, Schneider G, Fabbri M, Poshusta TL, Dusetti NJ, Baumgart S, Iovanna JL, Ellenrieder V, Urrutia R, Fernandez-Zapico ME (2013) Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis. Cancer Lett 328: 212-221.
16. Mees ST, Mardin WA, Wendel C, Baeumer N, Willscher E, Senninger N, Schleicher C, Colombo-Benkmann M, Haier J (2010) EP300 - a miRNAregulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas. Int J Cancer 126: 114-124.
17. Pei J, Grishin NV (2012) Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. Cell Signal 24: 758-769.
18. Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G (1998) A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392: 190-193.
19. Pryczynicz A, Guzińska-Ustymowicz K, Kemona A, Czyzewska J (2010) Expression of the E-cadherin-catenin complex in patients with pancreatic ductal adenocarcinoma. Folia Histochem Cytobiol 48: 128-133.
20. Siegel R, Naishadham D, Jemal A (2012) Cancer statistics, 2012. CA Cancer J Clin 62: 10-29.
21. Sohn TA, Yeo CJ, Cameron JL, Koniaris L, Kaushal S, Abrams RA, Sauter PK, Coleman J, Hruban RH, Lillemoe KD (2000) Resected adenocarcinoma of the pancreas-616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg 4: 567-579.
22. Suter CM, Martin DI, Ward RL (2004) Germline epimutation of MLH1 in individuals with multiple cancers. Nat Genet 36: 497-501.
23. Szafranska AE, Davison TS, John J, Cannon T, Sipos B, Maghnouj A, Labourier E, Hahn SA (2007) MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma. Oncogene 26: 4442-4452.
24. Thiery JP (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454.
25. Thiery JP, Acloque H, Huang RY, Nieto MA (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890.
26. Van den Bossche J, Malissen B, Mantovani A, De Baetselier P, Van Ginderachter JA (2012) Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs. Blood 119: 1623-1633.
27. van Roy F, Berx G (2008) The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci 65: 3756-3788.
28. Vinson CR, Conover S, Adler PN (1989) A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains. Nature 338: 263-264.
29. Zeng G, Germinaro M, Micsenyi A, Monga NK, Bell A, Sood A, Malhotra V, Sood N, Midda V, Monga DK, Kokkinakis DM, Monga SP (2006) Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma. Neoplasia 8: 279-289.