Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups

Clinical Cancer Research

Volumn 21, Issue 1, 2015, Pages 184-192

  Merino, Diana M ^a   Shlien, Adam ^a   Villani, Anita ^a   Pienkowska, Malgorzata ^a   Mack, Stephen ^a   Ramaswamy, Vijay ^a   Shih, David ^a   Tatevossian, Ruth ^b   Novokmet, Ana ^a   Choufani, Sanaa ^a   Dvir, Rina ^c   Ben Arush, Myran ^d   Harris, Brent T ^e   Hwang, Eugene I ^f   Lulla, Rishi ^g   Pfister, Stefan M ^h   Achatz, Maria Isabel ⁱ   Jabado, Nada ^j   Finlay, Jonathan L ^k   Weksberg, Rosanna ^a   Bouffet, Eric ^a   Hawkins, Cynthia ^a   Taylor, Michael D ^a   Tabori, Uri ^a   Ellison, David W ^b   Gilbertson, Richard J ^b   Malkin, David ^a   more..

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^d Rambam Health Care Campus ^*  (Israel)

^e GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^f CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^g CHILDREN'S MEMORIAL HOSPITAL   (United States)

^h GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

ⁱ A C CAMARGO CANCER CENTER   (Brazil)

^j MONTREAL CHILDREN S HOSPITAL   (Canada)

^k CHILDREN S HOSPITAL LOS ANGELES   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; ATYPICAL CHOROID PLEXUS PAPILLOMA; BRAIN TUMOR; CANCER RISK; CHOROID PLEXUS CARCINOMA; CHOROID PLEXUS PAPILLOMA; CHOROID PLEXUS TUMOR; CONTROLLED STUDY; DIPLOIDY; DISOMY; DNA CONTENT; DNA METHYLATION; EVENT FREE SURVIVAL; FEMALE; GENE DOSAGE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE SEGREGATION; GENETIC HETEROGENEITY; GENOME ANALYSIS; HIGH RISK PATIENT; HUMAN; HUMAN TISSUE; HYPERDIPLOID; HYPODIPLOID; MALE; MOLECULAR MODEL; OUTCOME ASSESSMENT; OVERALL SURVIVAL; RISK ASSESSMENT; RISK FACTOR; SOMATIC MUTATION; TRANSCRIPTOMICS; TUMOR SUPPRESSOR GENE; ADOLESCENT; BIOSYNTHESIS; CANCER STAGING; CHILD; CLASSIFICATION; DISEASE FREE SURVIVAL; GENETICS; INFANT; MUTATION; PATHOLOGY; PRESCHOOL CHILD; PROGNOSIS;

PROTEIN P53; TP53 PROTEIN, HUMAN; TUMOR PROTEIN;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CHOROID PLEXUS NEOPLASMS; DISEASE-FREE SURVIVAL; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INFANT; MALE; MUTATION; NEOPLASM PROTEINS; NEOPLASM STAGING; PROGNOSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84920664265     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-14-1324     Document Type: Article

References (19)

1. Ogiwara H, Dipatri AJ Jr, Alden TD, Bowman RM, Tomita T. Choroid plexus tumors in pediatric patients. Br J Neurosurg 2012;26:32-7.
2. Lafay-Cousin L, Keene D, Carret A-S, Fryer C, Brossard J, Crooks B, et al. Choroid plexus tumors in children less than 36 months: the Canadian Pediatric Brain Tumor Consortium (CPBTC) experience. Child's Nerv Syst 2011;27:259-64.
3. Addo NK, Kamaly-Asl ID, Josan VA, Kelsey AM, Estlin EJ. Preoperative vincristine for an inoperable choroid plexus papilloma: a case discussion and review of the literature. Case Rep 2011;8:149-53.
4. Rickert CH, Paulus W. Tumors of the choroid plexus. Microsc Res Tech 2001;52:104-11.
5. Tabori U, Shlien A, Baskin B, Levitt S, Ray P, Alon N, et al. TP53 alterations determine clinical subgroups and survival of patients with choroid plexus tumors. J Clin Oncol 2010;28:1995-2001.
6. Lafay-Cousin L, Mabbott DJ, Halliday W, Taylor MD, Tabori U, Kamaly-Asl ID, et al. Use of ifosfamide, carboplatin, and etoposide chemotherapy in choroid plexus carcinoma. J Neurosurg Pediatr 2010;5:615-21.
7. Jeibmann A, Hasselblatt M, Gerss J, Wrede B, Egensperger R, Beschorner R, et al. Prognostic implications of atypical histologic features in choroid plexus papilloma. J Neuropathol Exp Neurol 2006;65: 1069-73.
8. Wrede B, Hasselblatt M, Peters O, Thall PF, Kutluk T, Moghrabi A, et al. Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. J Neurooncol 2009;95:383-92.
9. Jeibmann A, Wrede B, Peters O, Wolff JE, Paulus W, Hasselblatt M. Malignant progression in choroid plexus papillomas. J Neurosurg 2007;107:199-202.
10. Van Loo P, Nordgard SH, Lingjñrde OC, Russnes HG, Rye IH, Sun W, et al. Allele-specific copy number analysis of tumors. Proc Natl Acad Sci U S A 2010;107:16910-5.
11. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette Ma, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 2005;102:15545-50.
12. Witt H, Mack SC, Ryzhova M, Bender S, Sill M, Isserlin R, et al. Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. Cancer Cell 2011;20:143-57.
13. Tuna M, Knuutila S, Mills GB. Uniparental disomy in cancer. Trends Mol Med 2009;15:120-8.
14. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114:97-109.
15. Dhillon RS, Wang YY, McKelvie PA, O'Brien B. Progression of choroid plexus papilloma. J Clin Neurosci 2013;20:1775-8.
16. Gozali AE, Britt B, Shane L, Gonzalez I, Gilles F, McComb JG, et al. Choroid plexus tumors; management, outcome, and association with the Li-Fraumeni syndrome: The Children's Hospital Los Angeles (CHLA) experience, 1991-2010. Pediatr Blood Cancer 2012;58:905-9.
17. Bettegowda C, Adogwa O, Mehta V, Chaichana KL, Weingart J, Carson BS, et al. Treatment of choroid plexus tumors: a 20-year single institutional experience. J Neurosurg Pediatr 2012;10:398-405.
18. Ruland V, Hartung S, Kordes U, Wolff JE, Paulus W, Hasselblatt M. Choroid plexus carcinomas are characterized by complex chromosomal alterations related to patient age and prognosis. Genes Chromosomes Cancer 2014;53:373-80.
19. Muller PAJ, Vousden KH. Mutant p53 in cancer: new functions and therapeutic opportunities. Cancer Cell 2014;25:304-17.