Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes

Frontiers in Microbiology

Volumn 5, Issue DEC, 2014, Pages

  Iannelli, Francesco ^a   Santagati, Maria ^b   Santoro, Francesco ^a   Oggioni, Marco R ^a,c   Stefani, Stefania ^b   Pozzi, Gianni ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

ICE; Macrolide resistance; Prophage; S. pyogenes; Tn1207.1; Tn1207.3; 1207.3

Indexed keywords

MACROLIDE;

AMPLICON; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; DNA SEQUENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PROPHAGE; STREPTOCOCCUS PYOGENES;

STREPTOCOCCUS PYOGENES;

EID: 84920662944     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2014.00687     Document Type: Article

References (28)

1. Banks, D. J., Porcella, S. F., Barbian, K. D., Beres, S. B., Philips, L. E., Voyich, J. M.,et al. (2004). Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain. J. Infect. Dis. 190, 727-738. doi: 10.1086/422697
2. Banks, D. J., Porcella, S. F., Barbian, K. D., Martin, J. M., and Musser, J. M. (2003). Structure and distribution of an unusual chimeric genetic element encoding macrolide resistance in phenotypically diverse clones of group A Streptococcus. J. Infect. Dis. 188, 1898-1908. doi: 10.1086/379897
3. Beres, S. B., and Musser, J. M. (2007). Contribution of exogenous genetic elements to the group A Streptococcus metagenome. PLoS ONE 8:e800. doi: 10.1371/journal.pone.0000800
4. Brenciani, A., Bacciaglia, A., Vignaroli, C., Pugnaloni, A., Varaldo, P. E., and Giovanetti, E. (2010). Φm46.1, the main Streptococcus pyogenes element carrying mef(A) and tet(O) genes. Antimicrob. Agents Chemother. 54, 221-229. doi: 10.1128/AAC.00499-09
5. Duplessis, M., and Moineau, S. (2001). Identification of a genetic determinant responsible for host specificity in Streptococcus thermophilus bacteriophages. Mol. Microbiol. 41, 325-336. doi: 10.1046/j.1365-2958.2001.02521.x
6. Euler, C. W., Ryan, P., Martin, J. M., and Φischetti, V. A. (2007). M.SpyI, a DNA methyltransferase encoded on a mefA chimeric element, modifies the genome of Streptococcus pyogenes. J. Bacteriol. 189, 1044-1054. doi: 10.1128/JB.01411-06
7. Giovanetti, E., Brenciani, A., Vecchi, M., Manzin, A., and Varaldo, P. E. (2005). Prophage association of mef(A) elements encoding e?ux-mediated erythromycin resistance in Streptococcus pyogenes. J. Antimicrob. Chemother. 55, 445-451. doi: 10.1093/jac/dki049
8. Iannelli, F., Santoro, F., Oggioni, M. R., and Pozzi, G. (2014). Nucleotide sequence analysis of integrative conjugative element Tn5253 of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 58, 1235-1239. doi: 10.1128/AAC.01764-13
9. Kinch, L. N., Ginalski, K., Rychlewski, L., and Grishin, N. V. (2005). Identification of novel restriction endonuclease-like fold families among hypothetical proteins. Nucleic Acids Res. 33, 3598-3605. doi: 10.1093/nar/gki676
10. Lévesque, C. M., Duplessis, M., Labonté, J., Labrie, S., Fremaux, C., Tremblay, D.,et al. (2005). Genomic organization and molecular analysis of virulent bacteriophage 2972 infecting an exopolysaccharide-producing Streptococcus thermophilus strain. Appl. Environ. Microbiol. 71, 4057-4068. doi: 10.1128/AEM.71.7.4057-4068.2005
11. Llull, D., López, R., and García, E. (2006). Skl, a novel choline-binding N-acetylmuramoyl-L-alanine amidase of Streptococcus mitis SK137 containing a CHAP domain. FEBS Lett. 580, 1959-1964. doi: 10.1016/j.febslet.2006.02.060
12. Moore, S. D., and Prevelige, P. E. J. (2002). DNA packaging: a new class of molecular motors. Curr. Biol. 12, R96-R98. doi: 10.1016/S0960-9822(02)00670-X
13. Munoz-Najar, U., and Vijayakumar, M. N. (1999). An operon that confers UV resistance by evoking the SOS mutagenic response in streptococcal conjugative transposon Tn5252. J. Bacteriol. 181, 2782-2788.
14. O'Driscoll, J., Heiter, D. F., Wilson, G. G., Fitzgerald, G. F., Roberts, R., and van Sinderen, D. (2006). A genetic dissection of the LlaJI restriction cassette reveals insights on a novel bacteriophage resistance system. BMC Microbiol. 6:40. doi: 10.1186/1471-2180-6-40
15. Pedersen, M., Østergaard, S., Bresciani, J., and Vogensen, F. K. (2000). Mutational analysis of two structural genes of the temperate lactococcal bacteriophage TP901-1 involved in tail length determination and baseplate assembly. Virology 276, 315-328. doi: 10.1006/viro.2000.0497
16. Pozzi, G., Iannelli, F., Oggioni, M. R., Santagati, M., and Stefani, S. (2004). Genetic elements carrying macrolide e?ux genes in streptococci. Curr. Drug Targets Infect. Disord. 4, 203-206. doi: 10.2174/1568005043340641
17. Råden, B., and Rutberg, L. (1984). Nucleotide sequence of the temperate Bacillus subtilis bacteriophage SPO2 DNA polymerase gene L. J. Virol. 52, 9-15.
18. Santagati, M., Iannelli, F., Cascone, C., Campanile, F., Oggioni, M. R., Stefani, S.,et al. (2003). The novel conjugative transposon Tn1207.3 carries the macrolide e?ux gene mef(A) in Streptococcus pyogenes. Microb. Drug Resist. 9, 243-247. doi: 10.1089/107662903322286445
19. Santagati, M., Iannelli, F., Oggioni, M. R., Stefani, S., and Pozzi, G. (2000). Characterization of a genetic element carrying the macrolide e?ux gene mef(A) in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 44, 2585-2587. doi: 10.1128/AAC.44.9.2585-2587.2000
20. Santoro, F., Oggioni, M. R., Pozzi, G., and Iannelli, F. (2010). Nucleotide sequence and functional analysis of the tet(M)-carrying conjugative transposon Tn5251 of Streptococcus pneumoniae. FEMS Microbiol. Lett. 308, 150-158. doi: 10.1111/j.1574-6968.2010.02002.x
21. Schouler, C., Ehrlich, S. D., and Chopin, M. C. (1994). Sequence and organization of the lactococcal prolate-headed bIL67 phage genome. Microbiology 140, 3061-3069. doi: 10.1099/13500872-140-11-3061
22. Smith, M. C., and Thorpe, H. M. (2002). Diversity in the serine recombinases. Mol. Microbiol. 44, 299-307. doi: 10.1046/j.1365-2958.2002.02891.x
23. Takusagawa, F., Kamitori, S., and Markham, G. D. (1996). Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution. Biochemistry 35, 2586-2596. doi: 10.1021/bi952604z
24. Wang, J., Hartling, J. A., and Flanagan, J. M. (1997). The structure of ClpP at 2.3 A resolution suggests a model for ATP-dependent proteolysis. Cell 91, 447-456. doi: 10.1016/S0092-8674(00)80431-6
25. Wang, L., and Archer, G. L. (2010). Roles of CcrA and CcrB in excision and integration of staphylococcal cassette chromosome mec, a Staphylococcus aureus genomic island. J. Bacteriol. 12, 3204-3212. doi: 10.1128/JB.01520-09
26. Yang, W., and Steitz, T. A. (1995). Crystal structure of the site-specific recombinase gamma delta resolvase complexed with a 34 bp cleavage site. Cell 82, 193-207. doi: 10.1016/0092-8674(95)90307-0
27. Yeo, H. J., Zieglin, G., Korolev, S., Calendar, R., Lanka, E., and Waksman, G. (2002). Phage P4 origin-binding domain structure reveals a mechanism for regulation of DNA-binding activity by homo- and heterodimerization of winged helix proteins. Mol. Microbiol. 43, 855-867. doi: 10.1046/j.1365-2958.2002.02796.x
28. Young, R., Wang, I. N., and Roof, W. D. (2000). Phages will out: strategies of host cell lysis. Trends Microbiol. 8, 120-128. doi: 10.1016/S0966-842X(00)01705-4