Plasma exchange to remove HIT antibodies: Dissociation between enzyme-immunoassay and platelet activation test reactivities

Blood

Volumn 125, Issue 1, 2015, Pages 195-198

  Warkentin, Theodore E ^a,b   Sheppard, Jo Ann I ^a   Chu, F Victor ^b   Kapoor, Anil ^b   Crowther, Mark A ^a,b   Gangji, Azim ^b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; HEPARIN PLATELET FACTOR 4 ANTIBODY; SEROTONIN; IMMUNOGLOBULIN G; THROMBOCYTE FACTOR 4;

AGED; ARTICLE; BLEEDING; CARDIOPULMONARY BYPASS; CASE REPORT; CORONARY ARTERY BYPASS GRAFT; CRYOPRECIPITATE; ENZYME IMMUNOASSAY; ERYTHROCYTE TRANSFUSION; FEMALE; HEART RIGHT ATRIUM; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; INFERIOR CAVA VEIN; KIDNEY CARCINOMA; NEPHRECTOMY; PLASMAPHERESIS; SEROTONIN RELEASE; SPLEEN INJURY; SPLENECTOMY; THROMBECTOMY; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; CARCINOMA; CHEMICALLY INDUCED; CHEMISTRY; COMPLICATION; DRUG EFFECTS; KIDNEY TUMOR; METABOLISM; PATHOLOGY; PROCEDURES; THROMBOCYTE; THROMBOCYTOPENIA; THROMBOSIS; TREATMENT OUTCOME;

AGED; BLOOD PLATELETS; CARCINOMA; FEMALE; HEMORRHAGE; HEPARIN; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOGLOBULIN G; KIDNEY NEOPLASMS; PLASMA EXCHANGE; PLATELET ACTIVATION; PLATELET FACTOR 4; THROMBOCYTOPENIA; THROMBOSIS; TREATMENT OUTCOME; VENA CAVA, INFERIOR;

EID: 84920627872     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-07-590844     Document Type: Article

References (15)

1. Warkentin TE, Greinacher A, Gruel Y, Aster RH, Chong BH; Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Laboratory testing for heparin-induced thrombocytopenia: a conceptual framework and implications for diagnosis. J Thromb Haemost. 2011; 9(12): 2498-2500.
2. Welsby IJ, Um J, Milano CA, Ortel TL, Arepally G. Plasmapheresis and heparin reexposure as a management strategy for cardiac surgical patients with heparin-induced thrombocytopenia. Anesth Analg. 2010; 110(1): 30-35.
3. Gilcher RO, Smith JW. Apheresis: principles and technology of hemapheresis. In: Simon TL, Snyder EL, Solheim BG, Stowell CP, Strauss RG, Petrides M, eds. In: Rossi's Principles of Transfusion Medicine, 4th ed. Bethesda, MD: AABB and Blackwell Press; 2009: 617-628.
4. Koster A, Selleng S. Management of intraoperative anticoagulation in patients with heparin-induced thrombocytopenia undergoing cardiovascular surgery. In: Warkentin TE, Greinacher A, eds. Heparin-Induced Thrombocytopenia, 5th ed. Boca Raton, FL: CRC Press; 2013: 550-572.
5. Sheridan D, Carter C, Kelton JG. A diagnostic test for heparin-induced thrombocytopenia. Blood. 1986; 67(1): 27-30.
6. Horsewood P, Warkentin TE, Hayward CPM, Kelton JG. The epitope specificity of heparin-induced thrombocytopenia. Br J Haematol. 1996; 95(1): 161-167.
7. Lo GK, Juhl D, Warkentin TE, Sigouin CS, Eichler P, Greinacher A. Evaluation of pretest clinical score (4 T's) for the diagnosis of heparin-induced thrombocytopenia in two clinical settings. J Thromb Haemost. 2006; 4(4): 759-765.
8. Warkentin TE, Greinacher A, Koster A, Lincoff AM. Treatment and prevention of heparin-induced thrombocytopenia. American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest. 2008; 133(6 Suppl): 340S-380S.
9. Selleng S, Haneya A, Hirt S, Selleng K, Schmid C, Greinacher A. Management of anticoagulation in patients with subacute heparin-induced thrombocytopenia scheduled for heart transplantation. Blood. 2008; 112(10): 4024-4027.
10. Warkentin TE, Sheppard JA. Serological investigation of patients with a previous history of heparin-induced thrombocytopenia who are reexposed to heparin. Blood. 2014; 123(16): 2485-2493.
11. Linkins LA, Dans AL, Moores LK, et al.; American College of Chest Physicians. Treatment and prevention of heparin-induced thrombocytopenia: antithrombotic therapy and prevention of thrombosis, 9th ed. American College of Chest Physicians Evidence-based Clinical Practice Guidelines. Chest. 2012; 141(2 Suppl): e495S-e530S.
12. Warkentin TE, Kelton JG. Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med. 2001; 344(17): 1286-1292.
13. Warkentin TE, Sheppard JI, Moore JC, Sigouin CS, Kelton JG. Quantitative interpretation of optical density measurements using PF4-dependent enzyme-immunoassays. J Thromb Haemost. 2008; 6(8): 1304-1312.
14. Greinacher A, Ittermann T, Bagemühl J, et al. Heparin-induced thrombocytopenia: towards standardization of platelet factor 4/heparin antigen tests. J Thromb Haemost. 2010; 8(9): 2025-2031.
15. McFarland J, Lochowicz A, Aster R, Chappell B, Curtis B. Improving the specificity of the PF4 ELISA in diagnosing heparin-induced thrombocytopenia. Am J Hematol. 2012; 87(8): 776-781.