MiR142-3p down regulation contributes to thyroid follicular tumorigenesis by targeting ASH1L and MLL1

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 1, 2015, Pages E59-E69

  Colamaio, Marianna ^a,b   Puca, Francesca ^a,b   Ragozzino, Elvira ^a,b   Gemei, Marica ^d   Decaussin Petrucci, Myriam ^c   Aiello, Concetta ^e   Bastos, André Uchimura ^a,b   Federico, Antonella ^g   Chiappetta, Gennaro ^e   Del Vecchio, Luigi ^d   Torregrossa, Liborio ^f   Battista, Sabrina ^a,b   Fusco, Alfredo ^a,b  

^a CNR   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITÉ LYON 1   (France)

^d CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^e NATIONAL CANCER INSTITUTE   (Italy)

^f UNIVERSITY OF PISA   (Italy)

^g INSTITUTO NACIONAL DE CÂNCER   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ABSENT SMALL OR HOMEOTIC LIKE 1 PROTEIN; HISTONE H3; LYSINE; MICRORNA; MICRORNA 142; MICRORNA 142 3P; MICRORNA 142 5P; MIXED LINEAGE LEUKEMIA 1 PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; ASH1L PROTEIN, HUMAN; DNA BINDING PROTEIN; MIRN142 MICRORNA, HUMAN; MIXED LINEAGE LEUKEMIA PROTEIN; MLL PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

3' UNTRANSLATED REGION; ARTICLE; CARCINOGENESIS; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE FUNCTION; HISTONE METHYLATION; HOMEOBOX; HUMAN; HUMAN CELL; HUMAN TISSUE; PROTEIN EXPRESSION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID ADENOMA; THYROID CELL; THYROID FOLLICULAR CARCINOMA; TRANSCRIPTION REGULATION; ADENOCARCINOMA; ADENOMA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; THYROID GLAND; THYROID TUMOR;

ADENOCARCINOMA, FOLLICULAR; ADENOMA; CARCINOGENESIS; CELL PROLIFERATION; DNA-BINDING PROTEINS; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; MYELOID-LYMPHOID LEUKEMIA PROTEIN; THYROID GLAND; THYROID NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 84920565385     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-2280     Document Type: Article

References (38)

1. Rossing M, Borup R, Henao R, et al. Down-regulation of microRNAs controlling tumourigenic factors in follicular thyroid carcinoma. J Mol Endocrinol. 2012;48:11-23.
2. Barbarotto E, Schmittgen TD, Calin GA. MicroRNAs and cancer: profile, profile, profile. Int J Cancer. 2008;122:969-977.
3. Pallante P, Battista S, Pierantoni GM, Fusco A. Deregulation of microRNA expression in thyroid neoplasias. Nat Rev Endocrinol. 2014;10:88-101.
4. Visone R, Russo L, Pallante P, et al. MicroRNAs (miR)-221 and miR-222, both overexpre ssed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle. Endocr Relat Cancer. 2007;14:791-798.
5. Colamaio M, Borbone E, Russo L, et al. miR-191 down-regulation plays a role in thyroid follicular tumors through CDK6 targeting. J Clin Endocrinol Metab. 2011;96:E1915-1924.
6. Colamaio M, Calí G, Sarnataro D, et al. Let-7a down-regulation plays a role in thyro id neoplasias of follicular histotype affecting cell adhesion and migration through its ability to target the FXYD5 (Dysadherin) gene. J Clin Endocrinol Metab. 2012;97:E2168-2178.
7. Wu L, Cai C, Wang X, Liu M, Li X, Tang H. MicroRNA-142-3p, a new regulator of RAC1, suppresses the migration and invasion of hepatocellular carcinoma cells. FEBS Lett. 2011;585:1322-1330.
8. Shen WW, Zeng Z, Zhu WX, Fu GH. MiR-142-3p functions as a tumor suppressor by targeting CD133, ABCG2, and Lgr5 in colon cancer cells. J Mol Med (Berl). 2013;91:989-1000.
9. Schuettengruber B, Martinez AM, Iovino N, Cavalli G. Trithorax group proteins: switching genes on and keeping them active. Nat Rev Mol Cell Biol. 2011;12:799-814.
10. Takahashi Y, Hamada J, Murakawa K, et al. Expression profil es of 39HOXgenes in normalhumanadult organs and anaplastic thyroid cancer cell lines by quantitative real-time RT-PCR system. Exp Cell Res. 2004;293:144-153.
11. Cantile M, Scognamiglio G, La Sala L, et al. Aberrant expression of posteriorHOXgenes in well different fine needle aspiration biopsies (FNAB)iated histotypes of thyroid cancers. Int J Mol Sci. 2013;14: 21727-21740.
12. Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F. The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. EMBO J. 19 94;13:3339-3347.
13. Gregory GD, Vakoc CR, Rozovskaia T, et al. Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes. Mol Cell Biol. 2007;27:8466-8479.
14. McCarty SK,Saji M,Zhang X,et al. Group I p21-Activated kinases regulate thyroid cancer cell migration and are overexpressed and activated in thyroid cancer invasion Endocr Relat Cancer. 2010 17 989-999.
15. Tanaka Y, Kawahashi K, Katagiri Z, Nakayama Y, Mahajan M, Kioussis D. Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression. PLoS One. 2011;6: e28171.
16. Tanaka Y, Katagiri Z, Kawahashi K, Kioussis D, Kitajima S. Trithorax-group protein ASH1 methylates histone H3 lysine 36. Gene. 2007;397:161-168.
17. Tanaka Y, Nakayama Y, Taniguchi M, Kioussis D. Regulation of early T cell development by the PHD finger of histone lysine methyltransferase ASH1. Biochem Biophys Res Commun. 2008;365: 58 9-594.
18. Schwarz DS, Hutvágner G, Du T, Xu Z, Aronin N, Zamore PD. Asymmetry in the assembly of the RNAi enzyme complex. Cell. 2003;115:199-208.
19. Skårn M, Barøy T, Stratford EW, Myklebost O. Epigenetic regulation and functional characterization of microRNA-142 in mesenchymal cells. PLoS One. 2013;8:e79231.
20. Mills AA. Throwing the cancer switch : reciprocal roles of polycomb and trithorax proteins. Nat Rev Cancer. 2010;10:669-682.
21. Yu BD, Hanson RD, Hess JL, Horning SE, Korsmeyer SJ. MLL, a mammalian trithorax-group gene, functi ons as a transcriptional maintenance factor in morphogenesis. Proc Natl Acad Sci USA. 1998;95:10632-10636.
22. Miyazaki H, Higashimoto K, Yada Y, Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract polycomb silencing. PLoS Genet 2013;9:e1003897.
23. Blobel GA, Kadauke S, Wang E, et al. A reconfigured pattern of MLL occupancy within mitotic chromati n promotes rapid transcriptional reactivation following mitotic exit. Mol Cell. 2009;36: 970-983.
24. Steffen PA, Fonseca JP, G änger C, et al. Quantitative in vivo analysis of chromatin binding o f Polycomb and Trithorax group proteins reveals retention of ASH1 on mitotic chromatin. Nucl Acids Res. 2013;41:5235-5250.
25. Gu B, Lee MG. Histone H3 lysine 4 methyltransferases and demethylases in self-renewal and differentiation of stem cells. Cell Biosci. 2013;3:39.
26. Tkachuk DC, Kohler S., and Cleary M.L. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell. 1992;71:691-700.
27. Krivtsov AV, Armstrong SA. MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer. 2007;7:823-833.
28. Takeda S, Liu H, Sasagawa S, et al. HGF-MET signals via the MLLETS2 complex in hepatocellular carcinoma. J Clin Invest. 2013; 123:3154-3165.
29. Ansari KI, Kasiri S, Mandal SS. Histone methylaseMLL1has critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo. Oncogene. 2013;32:3359-3370.
30. Liu J, Lee W, Jiang Z, et al. Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events. Genome Res. 2012;22:2315-2327.
31. Mouradov D, Sloggett C, Jorissen RN, et al. Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer. Cancer Res. 2014;74:3238-47.
32. Guenther MG, Jenner RG, Chevalier B, et al. Global and Hox-specific roles for the MLL1 methyltransferase. Proc Natl Acad Sci USA. 2005;102:8603-8608.
33. Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic lineage differentiation. Science. 2004;303:83-86.
34. Lu X, Li X, He Q, et al. miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates. Cell Res. 2013;23:1356-1368.
35. Ding S,Liang Y,Zhao M,et al. Decreased microRNA-142-3p/5p expression causes CD4 T cell activati on and B cell hyperstimulation in systemic lupus erythematosus Arthritis Rheum. 2012 64 2953-2963.
36. Namløs HM, Meza-Zepeda LA, Barøy T, et al. Modulation of the osteosarcoma expression phenotype by microRNAs. PLoS One. 2012;7:e48086.
37. Chang SS, Jiang WW, Smith I, et al. MicroRNA alterations in head and neck squamous cell carcinoma. Int J Cancer. 2008;123:2791-2797.
38. Di Leva G, Piovan C, Gasparini P, et al. Estrogen mediated-Activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. PLoS Genet 20 13; 9:e1003311.