A pathogenesis-based transcript signature in donor-specific antibody-positive kidney transplant patients with normal biopsies

Genomics Data

Volumn 2, Issue , 2014, Pages 357-360

  Broin, P O ^a   Hayde, N ^b   Bao, Y ^a   Ye, B ^a   Calder, R B ^a   de Boccardo, G ^a   Lubetzky, M ^a   Ajaimy, M ^a   Pullman, J ^a   Colovai, A ^a   Akalin, E ^a   Golden, A ^a,c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c YESHIVA UNIVERSITY   (United States)

Author keywords

Antibody mediated rejection; Donor specific antibodies; Gene expression; Kidney; Transplant

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CD45 ANTIGEN;

ADULT; ANTIBODY MEDIATED REJECTION; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE ONTOLOGY; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOASSAY; KIDNEY BIOPSY; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; NUCLEOTIDE SEQUENCE; PHENOTYPE; T LYMPHOCYTE ACTIVATION; UPREGULATION;

EID: 84920549625     PISSN: 22135960     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gdata.2014.10.005     Document Type: Article

References (9)

1. Hayde N., Broin P.O., Bao Y., de Boccardo G., Lubetzky M., Ajaimy M., Pullman J., Colovai A., Golden A., Akalin E. Increased intragraft rejection-associated gene transcripts in patients with donor-specific antibodies and normal biopsies. Kidney Int. 2014, 86:600-609.
2. Einecke G., Sis B., Reeve J., Mengel M., Campbell P.M., Hidalgo L.G., Kaplan B., Halloran P.F. Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure. Am. J. Transplant. 2009, 9:2520-2531.
3. Sellarés J., de Freitas D.G., Mengel M., Reeve J., Einecke G., Sis B., Hidalgo L.G., Famulski K., Matas A., Halloran P.F. Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence. Am. J. Transplant. 2012, 12:388-399.
4. Bhowmik D.M., Dinda A.K., Mahanta P., Agarwal S.K. The evolution of the Banff classification schema for diagnosing renal allograft rejection and its implications for clinicians. Indian J. Nephrol. 2010, 20(1):2-8.
5. Carvalho B.S., Irizarry R.A. A framework for oligonucleotide microarray preprocessing. Bioinformatics 2010, 26(19):2363-2367.
6. Smyth G.K. Limma: linear models for microarray data. Bioinformatics and Computational Biology Solutions Using R and Bioconductor 2005, 397-420. Springer, New York. R. Gentleman, V. Carey, S. Dudoit, R. Irizarry, W. Huber (Eds.).
7. Falcon S., Gentleman R. Using GOstats to test gene lists for GO term association. Bioinformatics 2007, 23(2):257-258.
8. Subramanian A., Tamayo P., Mootha V.K., Mukherjee S., Ebert B.L., Gillette M.A., Paulovich A., Pomeroy S.L., Golub T.R., Lander E.S., Mesirov J.P. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U. S. A. 2005, 102(43):15545-15550. https://startpage.com/.
9. Sellarés J., Reeve J., Loupy A., Mengel M., Sis B., Skene A., de Freitas D.G., Kreepala C., Hidalgo L.G., Famulski K.S., Halloran P.F. Molecular diagnosis of antibody-mediated rejection in human kidney transplants. Am. J. Transplant. 2013, 13(4):971-983.