메뉴 건너뛰기




Volumn 28, Issue 1, 2015, Pages 55-65

Interferon-based combination treatment for chronic hepatitis C in the era of direct acting antivirals

Author keywords

Cyclophilin inhibitors; NS5A inhibitors; NS5B polymerase inhibitors; Pegylated interferon plus ribavirin; Protease inhibitors

Indexed keywords

ALISPORIVIR; ASUNAPREVIR; BOCEPREVIR; DACLATASVIR; DANOPREVIR; FALDAPREVIR; GRAZOPREVIR; INTERLEUKIN 28B; LEDIPASVIR; LOMIBUVIR; MERICITABINE; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4A; NONSTRUCTURAL PROTEIN 5B; OMBITASVIR; PEGINTERFERON; PLACEBO; PROTEINASE INHIBITOR; RIBAVIRIN; SIMEPREVIR; SOFOSBUVIR; TELAPREVIR; VANIPREVIR; VEDROPREVIR;

EID: 84920410351     PISSN: 11087471     EISSN: 17927463     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (47)

References (77)
  • 1
    • 30044432484 scopus 로고    scopus 로고
    • American Gastroenterological Association technical review on the management of hepatitis C
    • Dienstag JL, McHutchison JG. American Gastroenterological Association technical review on the management of hepatitis C. Gastroenterology 2006;130:231-264;214-217.
    • (2006) Gastroenterology , vol.130 , Issue.231-264 , pp. 214-217
    • Dienstag, J.L.1    McHutchison, J.G.2
  • 2
    • 23944480609 scopus 로고    scopus 로고
    • Hepatitis C and liver transplantation
    • Brown RS. Hepatitis C and liver transplantation. Nature 2005;436:973-978.
    • (2005) Nature , vol.436 , pp. 973-978
    • Brown, R.S.1
  • 3
    • 79960453276 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: Management of hepatitis C virus infection
    • European Association for the Study of the Liver. EASL clinical practice guidelines: management of hepatitis C virus infection. J Hepatol 2011;55:245-264.
    • (2011) J Hepatol , vol.55 , pp. 245-264
  • 4
    • 65449136656 scopus 로고    scopus 로고
    • American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: An update
    • Ghany MG, Strader DB, Thomas DL, Seeff LB; American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009;49:1335-1374.
    • (2009) Hepatology , vol.49 , pp. 1335-1374
    • Ghany, M.G.1    Strader, D.B.2    Thomas, D.L.3    Seeff, L.B.4
  • 5
    • 69249101721 scopus 로고    scopus 로고
    • Treatment options for patients with chronic hepatitis C not responding to initial antiviral therapy
    • Jacobson IM. Treatment options for patients with chronic hepatitis C not responding to initial antiviral therapy. Clin Gastroenterol Hepatol 2009;7:921-930.
    • (2009) Clin Gastroenterol Hepatol , vol.7 , pp. 921-930
    • Jacobson, I.M.1
  • 8
    • 34547734952 scopus 로고    scopus 로고
    • Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus
    • Jones CT, Murray CL, Eastman DK, Tassello J, Rice CM. Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus. J Virol 2007;81:8374-8383.
    • (2007) J Virol , vol.81 , pp. 8374-8383
    • Jones, C.T.1    Murray, C.L.2    Eastman, D.K.3    Tassello, J.4    Rice, C.M.5
  • 10
    • 33744507185 scopus 로고    scopus 로고
    • From structure to function: New insights into hepatitis C virus RNA replication
    • Appel N, Schaller T, Penin F, Bartenschlager R. From structure to function: new insights into hepatitis C virus RNA replication. J Biol Chem 2006;281:9833-9836.
    • (2006) J Biol Chem , vol.281 , pp. 9833-9836
    • Appel, N.1    Schaller, T.2    Penin, F.3    Bartenschlager, R.4
  • 11
    • 47749092840 scopus 로고    scopus 로고
    • NS3 helicase domains involved in infectious intracellular hepatitis C virus particle assembly
    • Ma Y, Yates J, Liang Y, Lemon SM, Yi M. NS3 helicase domains involved in infectious intracellular hepatitis C virus particle assembly. J Virol 2008;82:7624-7639.
    • (2008) J Virol , vol.82 , pp. 7624-7639
    • Ma, Y.1    Yates, J.2    Liang, Y.3    Lemon, S.M.4    Yi, M.5
  • 12
    • 60049083503 scopus 로고    scopus 로고
    • The hepatitis C virus NS4B protein can trans-complement viral RNA replication and modulates production of infectious virus
    • Jones DM, Patel AH, Targett-Adams P, McLauchlan J. The hepatitis C virus NS4B protein can trans-complement viral RNA replication and modulates production of infectious virus. J Virol 2009;83:2163-2177.
    • (2009) J Virol , vol.83 , pp. 2163-2177
    • Jones, D.M.1    Patel, A.H.2    Targett-Adams, P.3    McLauchlan, J.4
  • 13
    • 42949145532 scopus 로고    scopus 로고
    • Regulation of hepatitis C virion production via phosphorylation of the NS5A protein
    • Tellinghuisen TL, Foss KL, Treadaway J. Regulation of hepatitis C virion production via phosphorylation of the NS5A protein. PLoS Pathol 2008;4:e1000032.
    • (2008) PLoS Pathol , vol.4
    • Tellinghuisen, T.L.1    Foss, K.L.2    Treadaway, J.3
  • 14
    • 80053339008 scopus 로고    scopus 로고
    • American Association for Study of Liver Diseases. An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases
    • Ghany MG, Nelson DR, Strader DB, Thomas DL, Seeff LB.; American Association for Study of Liver Diseases. An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology 2011;54:1433-1444.
    • (2011) Hepatology , vol.54 , pp. 1433-1444
    • Ghany, M.G.1    Nelson, D.R.2    Strader, D.B.3    Thomas, D.L.4    Seeff, L.B.5
  • 15
    • 34247594930 scopus 로고    scopus 로고
    • Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
    • Sarrazin C, Kieffer TL, Bartels D, et al. Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir. Gastroenterology 2007;132:1767-1777.
    • (2007) Gastroenterology , vol.132 , pp. 1767-1777
    • Sarrazin, C.1    Kieffer, T.L.2    Bartels, D.3
  • 16
    • 73149113353 scopus 로고    scopus 로고
    • Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients
    • Susser S, Welsch C, Wang Y, et al. Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients. Hepatology 2009;50:1709-1718.
    • (2009) Hepatology , vol.50 , pp. 1709-1718
    • Susser, S.1    Welsch, C.2    Wang, Y.3
  • 17
    • 79958830099 scopus 로고    scopus 로고
    • Hepatitis C virus resistance to protease inhibitors
    • Halfon P, Locarnini S. Hepatitis C virus resistance to protease inhibitors. J Hepatol 2011;55:192-206.
    • (2011) J Hepatol , vol.55 , pp. 192-206
    • Halfon, P.1    Locarnini, S.2
  • 18
    • 84855212109 scopus 로고    scopus 로고
    • New targets for antiviral therapy of chronic hepatitis C
    • Bühler S, Bartenschlager R. New targets for antiviral therapy of chronic hepatitis C. Liver Int 2012;32(Suppl 1):9-16.
    • (2012) Liver Int , vol.32 , pp. 9-16
    • Bühler, S.1    Bartenschlager, R.2
  • 19
    • 84864602817 scopus 로고    scopus 로고
    • The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors
    • Romano KP, Ali A, Aydin C, et al. The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors. PLoS Pathog 2012;8:e1002832.
    • (2012) PLoS Pathog , vol.e1002832 , pp. 8
    • Romano, K.P.1    Ali, A.2    Aydin, C.3
  • 20
    • 34548285424 scopus 로고    scopus 로고
    • Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase
    • Koch U, Narjes F. Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. Curr Top Med Chem 2007;7:1302-1329.
    • (2007) Curr Top Med Chem , vol.7 , pp. 1302-1329
    • Koch, U.1    Narjes, F.2
  • 21
    • 84862816908 scopus 로고    scopus 로고
    • Recent progress in the development of selected hepatitis C virus NS3.4A protease and NS5B polymerase inhibitors
    • Kwong AD, McNair L, Jacobson I, George S. Recent progress in the development of selected hepatitis C virus NS3.4A protease and NS5B polymerase inhibitors. Curr Opin Pharmacol 2008;8:522-531.
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 522-531
    • Kwong, A.D.1    McNair, L.2    Jacobson, I.3    George, S.4
  • 22
    • 84921028832 scopus 로고    scopus 로고
    • Mericitabine and ritonavir-boosted danoprevir with or without ribavirin in treatment-naive HCV genotype 1 patients: INFORM-SVR study
    • Epub ahead of print
    • Gane EJ, Pockros PJ, Zeuzem S, et al. Mericitabine and ritonavir-boosted danoprevir with or without ribavirin in treatment-naive HCV genotype 1 patients: INFORM-SVR study. Liver Int 2014 doi: 10.1111/liv.12588 [Epub ahead of print].
    • (2014) Liver Int
    • Gane, E.J.1    Pockros, P.J.2    Zeuzem, S.3
  • 23
    • 84856159009 scopus 로고    scopus 로고
    • Preliminary study of two antiviral agents for hepatitis C genotype 1
    • Lok AS, Gardiner DF, Lawitz E, et al. Preliminary study of two antiviral agents for hepatitis C genotype 1. N Engl J Med 2012;366:216-224.
    • (2012) N Engl J Med , vol.366 , pp. 216-224
    • Lok, A.S.1    Gardiner, D.F.2    Lawitz, E.3
  • 24
    • 84883219967 scopus 로고    scopus 로고
    • Resistance analysis of hepatitis C virus genotype 1 prior treatment null responders receiving daclatasvir and asunaprevir
    • McPhee F, Hernandez D, Yu F, et al. Resistance analysis of hepatitis C virus genotype 1 prior treatment null responders receiving daclatasvir and asunaprevir. Hepatology 2013;58:902-911.
    • (2013) Hepatology , vol.58 , pp. 902-911
    • McPhee, F.1    Hernandez, D.2    Yu, F.3
  • 25
    • 84896460675 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A inhibitors and drug resistance mutations
    • Nakamoto S, Kanda T, Wu S, et al. Hepatitis C virus NS5A inhibitors and drug resistance mutations. World J Gastroenterol 2014;20:2902-2912.
    • (2014) World J Gastroenterol , vol.20 , pp. 2902-2912
    • Nakamoto, S.1    Kanda, T.2    Wu, S.3
  • 26
    • 84921433851 scopus 로고    scopus 로고
    • Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1
    • Epub ahead of print
    • Kosaka K, Imamura M, Hayes CN, et al. Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1. J Viral Hepat 2014. doi: 10.1111/ jvh.12271 [Epub ahead of print].
    • (2014) J Viral Hepat
    • Kosaka, K.1    Imamura, M.2    Hayes, C.N.3
  • 27
    • 84896520682 scopus 로고    scopus 로고
    • Antiviral therapy of hepatitis C in 2014: Do we need resistance testing?
    • Schneider MD, Sarrazin C. Antiviral therapy of hepatitis C in 2014: do we need resistance testing? Antiviral Res 2014;105:64-71.
    • (2014) Antiviral Res , vol.105 , pp. 64-71
    • Schneider, M.D.1    Sarrazin, C.2
  • 28
    • 66149129922 scopus 로고    scopus 로고
    • The cyclophilin inhibitor DEBIO-025 combined with PEG IFN-alpha2a significantly reduces viral load in treatment naive hepatitis C patients
    • Flisiak R, Feinman SV, Jablkowski M, et al. The cyclophilin inhibitor DEBIO-025 combined with PEG IFN-alpha2a significantly reduces viral load in treatment naive hepatitis C patients. Hepatology 2009;49:1460-1468.
    • (2009) Hepatology , vol.49 , pp. 1460-1468
    • Flisiak, R.1    Feinman, S.V.2    Jablkowski, M.3
  • 29
    • 79955815806 scopus 로고    scopus 로고
    • Sustained virological response with 29 days of DEBIO-025 monotherapy in hepatitis C virus genotype 3
    • Patel H, Heathcote EJ. Sustained virological response with 29 days of DEBIO-025 monotherapy in hepatitis C virus genotype 3. Gut 2011;60:879.
    • (2011) Gut , vol.60 , pp. 879
    • Patel, H.1    Heathcote, E.J.2
  • 30
    • 79960446187 scopus 로고    scopus 로고
    • Once-daily alisporivir (DEB025) plus peginterferon alfa-2a/ribavirin results in superior sustained virologic response in chronic hepatitis C genotype 1 treatment-naive patients
    • Flisiak R, Pawlotsky JM, Crabbe R, et al. Once-daily alisporivir (DEB025) plus peginterferon alfa-2a/ribavirin results in superior sustained virologic response in chronic hepatitis C genotype 1 treatment-naive patients. J Hepatol 2011;54(Suppl 1):S2.
    • (2011) J Hepatol , vol.54 , pp. S2
    • Flisiak, R.1    Pawlotsky, J.M.2    Crabbe, R.3
  • 31
    • 79959438789 scopus 로고    scopus 로고
    • ADVANCE Study Team. Telaprevir for previously untreated chronic hepatitis C virus infection
    • Jacobson I., McHutchison JG, Dusheiko G, et al.; ADVANCE Study Team. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med 2011;364:2405-2416.
    • (2011) N Engl J Med , vol.364 , pp. 2405-2416
    • Jacobson, I.1    McHutchison, J.G.2    Dusheiko, G.3
  • 32
    • 80052826527 scopus 로고    scopus 로고
    • ILLUMINATE Study Team. Response-guided telaprevir combination treatment for hepatitis C virus infection
    • Sherman KE, Flamm SL, Afdhal NH, et al.; ILLUMINATE Study Team. Response-guided telaprevir combination treatment for hepatitis C virus infection. N Engl J Med 2011;365:1014-1024.
    • (2011) N Engl J Med , vol.365 , pp. 1014-1024
    • Sherman, K.E.1    Flamm, S.L.2    Afdhal, N.H.3
  • 33
    • 79953173221 scopus 로고    scopus 로고
    • SPRINT-2 Investigators. Boceprevir for untreated chronic HCV genotype 1 infection
    • Poordad F, McCone J Jr, Bacon BR.; SPRINT-2 Investigators. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med 2011;364:1195-1206.
    • (2011) N Engl J Med , vol.364 , pp. 1195-1206
    • Poordad, F.1    McCone, J.2    Bacon, B.R.3
  • 34
    • 79959381354 scopus 로고    scopus 로고
    • REALIZE Study Team. Telaprevir for retreatment of HCV infection
    • Zeuzem S, Andreone P, Pol S, et al.; REALIZE Study Team. Telaprevir for retreatment of HCV infection. N Engl J Med 2011;364:2417-2428.
    • (2011) N Engl J Med , vol.364 , pp. 2417-2428
    • Zeuzem, S.1    Andreone, P.2    Pol, S.3
  • 35
    • 79953176289 scopus 로고    scopus 로고
    • RESPOND-2 Investigators. Boceprevir for previously treated chronic HCV genotype 1 infection
    • Bacon BR, Gordon SC, Lawitz E, RESPOND-2 Investigators. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med 2011;364:1207-1217.
    • (2011) N Engl J Med , vol.364 , pp. 1207-1217
    • Bacon, B.R.1    Gordon, S.C.2    Lawitz, E.3
  • 36
    • 84896400773 scopus 로고    scopus 로고
    • Boceprevir for chronic HCV genotype 1 infection in patients with prior treatment failure to peginterferon/ribavirin, including prior null response
    • Vierling JM, Davis M, Flamm S, et al. Boceprevir for chronic HCV genotype 1 infection in patients with prior treatment failure to peginterferon/ribavirin, including prior null response. J Hepatol 2014;60:748-756.
    • (2014) J Hepatol , vol.60 , pp. 748-756
    • Vierling, J.M.1    Davis, M.2    Flamm, S.3
  • 37
    • 84894312806 scopus 로고    scopus 로고
    • Telaprevir twice daily is noninferior to telaprevir every 8 hours for patients with chronic hepatitis C
    • Buti M, Agarwal K, Horsmans Y, et al. Telaprevir twice daily is noninferior to telaprevir every 8 hours for patients with chronic hepatitis C. Gastroenterology 2014;146:744-753.
    • (2014) Gastroenterology , vol.146 , pp. 744-753
    • Buti, M.1    Agarwal, K.2    Horsmans, Y.3
  • 38
    • 84902953427 scopus 로고    scopus 로고
    • UPIC Study Group. Effectiveness of telaprevir or boceprevir in treatment-experienced patients with HCV genotype 1 infection and cirrhosis
    • Hézode C, Fontaine H, Dorival C, et al.; CUPIC Study Group. Effectiveness of telaprevir or boceprevir in treatment-experienced patients with HCV genotype 1 infection and cirrhosis. Gastroenterology 2014;147:132-142.
    • (2014) Gastroenterology , vol.147 , pp. 132-142
    • Hézode, C.1    Fontaine, H.2    Dorival, C.3
  • 39
    • 84882908504 scopus 로고    scopus 로고
    • CUPIC Study Group. Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) - NCT01514890
    • Hézode C, Fontaine H, Dorival C, et al; CUPIC Study Group. Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) - NCT01514890. J Hepatol 2013;59:434-441.
    • (2013) J Hepatol , vol.59 , pp. 434-441
    • Hézode, C.1    Fontaine, H.2    Dorival, C.3
  • 40
    • 84888871431 scopus 로고    scopus 로고
    • HCV-TARGET: A longitudinal, observational study of North American patients with chronic hepatitis C (HCV treated with boceprevir or telaprevir
    • Fried MW, Reddy KR, Di Bisceglie AM, et al. HCV-TARGET: A longitudinal, observational study of North American patients with chronic hepatitis C (HCV treated with boceprevir or telaprevir. J Hepatol 2013;58:S335.
    • (2013) J Hepatol , vol.58 , pp. S335
    • Fried, M.W.1    Reddy, K.R.2    Di Bisceglie, A.M.3
  • 41
    • 84904741728 scopus 로고    scopus 로고
    • Safety and efficacy of boceprevir/peginterferon/ribavirin for HCV G1 compensated cirrhotics: Meta-analysis of 5 trials
    • Vierling JM, Zeuzem S, Poordad F, et al. Safety and efficacy of boceprevir/peginterferon/ribavirin for HCV G1 compensated cirrhotics: Meta-analysis of 5 trials. J Hepatol 2014;61:200-209.
    • (2014) J Hepatol , vol.61 , pp. 200-209
    • Vierling, J.M.1    Zeuzem, S.2    Poordad, F.3
  • 42
    • 84888295678 scopus 로고    scopus 로고
    • Once-daily simeprevir (TMC435) with pegylated interferon and ribavirin in treatment-naïve genotype 1 hepatitis C: The randomized PILLAR study
    • Fried MW, Buti M, Dore GJ, et al. Once-daily simeprevir (TMC435) with pegylated interferon and ribavirin in treatment-naïve genotype 1 hepatitis C: the randomized PILLAR study. Hepatology 2013;58:1918-1929.
    • (2013) Hepatology , vol.58 , pp. 1918-1929
    • Fried, M.W.1    Buti, M.2    Dore, G.J.3
  • 43
    • 84892806505 scopus 로고    scopus 로고
    • Simeprevir increases rate of sustained virologic response among treatment-experienced patients with HCV genotype-1 infection: A phase IIb trial
    • Zeuzem S, Berg T, Gane E, et al. Simeprevir increases rate of sustained virologic response among treatment-experienced patients with HCV genotype-1 infection: a phase IIb trial. Gastroenterology 2014;146:430-441.
    • (2014) Gastroenterology , vol.146 , pp. 430-441
    • Zeuzem, S.1    Berg, T.2    Gane, E.3
  • 44
    • 84901217985 scopus 로고    scopus 로고
    • Simeprevir with peginterferon and ribavirin leads to high rates of SVR in patients with HCV genotype 1 Who relapsed after previous therapy: A phase 3 trial
    • Forns X, Lawitz E, Zeuzem S, et al. Simeprevir with peginterferon and ribavirin leads to high rates of SVR in patients with HCV genotype 1 Who relapsed after previous therapy: a phase 3 trial. Gastroenterology 2014;146:1669-1679.
    • (2014) Gastroenterology , vol.146 , pp. 1669-1679
    • Forns, X.1    Lawitz, E.2    Zeuzem, S.3
  • 45
    • 84906053496 scopus 로고    scopus 로고
    • Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1infection (QUEST-1): A phase 3, randomised, double-blind, placebo-controlled trial
    • Jacobson I., Dore GJ, Foster GR, et al. Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet 2014;384:403-413.
    • (2014) Lancet , vol.384 , pp. 403-413
    • Jacobson, I.1    Dore, G.J.2    Foster, G.R.3
  • 46
    • 84906059095 scopus 로고    scopus 로고
    • Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): A randomised, double-blind, placebo-controlled phase 3 trial
    • Manns M, Marcellin P, Poordad F, et al. Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2014;384:414-426.
    • (2014) Lancet , vol.384 , pp. 414-426
    • Manns, M.1    Marcellin, P.2    Poordad, F.3
  • 47
    • 84904707593 scopus 로고    scopus 로고
    • EASL recommendations on treatment of hepatitis C 2014. J Hepatol 2014;61:373-395.
    • (2014) J Hepatol , vol.61 , pp. 373-395
  • 48
    • 84878976866 scopus 로고    scopus 로고
    • Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naïve patients with hepatitis C genotype-1 infection (ATOMIC): An open-label, randomised, multicentre phase 2 trial
    • Kowdley KV, Lawitz E, Crespo I, et al. Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naïve patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial. Lancet 2013;381:2100-2107.
    • (2013) Lancet , vol.381 , pp. 2100-2107
    • Kowdley, K.V.1    Lawitz, E.2    Crespo, I.3
  • 49
    • 84877730954 scopus 로고    scopus 로고
    • Sofosbuvir for previously untreated chronic hepatitis C infection
    • Lawitz E, Mangia A, Wyles D, et al. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med 2013;368:1878-1887.
    • (2013) N Engl J Med , vol.368 , pp. 1878-1887
    • Lawitz, E.1    Mangia, A.2    Wyles, D.3
  • 50
    • 84895466397 scopus 로고    scopus 로고
    • Sofosbuvir in combination with PegIFN and ribavirin for 12 weeks provides wigh SVR rates in HCV-infected genotype 2 or 3 treatment-experienced patients with and without compensated cirrhosis: Results from the LONESTAR-2 study
    • Lawitz E, Poordad F, Brainard D, et al. Sofosbuvir in combination with PegIFN and ribavirin for 12 weeks provides wigh SVR rates in HCV-infected genotype 2 or 3 treatment-experienced patients with and without compensated cirrhosis: results from the LONESTAR-2 study. Hepatology 2013;58:1380A.
    • (2013) Hepatology , vol.1380A , pp. 58
    • Lawitz, E.1    Poordad, F.2    Brainard, D.3
  • 51
    • 84878992253 scopus 로고    scopus 로고
    • Faldaprevir combined with pegylated interferon alfa-2a and ribavirin in treatment-naïve patients with chronic genotype 1 HCV: SILEN-C1 trial
    • Sulkowski MS, Asselah T, Lalezari J, et al. Faldaprevir combined with pegylated interferon alfa-2a and ribavirin in treatment-naïve patients with chronic genotype 1 HCV: SILEN-C1 trial. Hepatology 2013;57:2143-2154.
    • (2013) Hepatology , vol.57 , pp. 2143-2154
    • Sulkowski, M.S.1    Asselah, T.2    Lalezari, J.3
  • 52
    • 84901249508 scopus 로고    scopus 로고
    • SILEN-C3, a Phase 2 Randomized Trial with Faldaprevir plus Pegylated Interferon α-2a and Ribavirin in Treatment-Naive Hepatitis C Virus Genotype 1-Infected Patients
    • Dieterich D, Asselah T, Guyader D, et al. SILEN-C3, a Phase 2 Randomized Trial with Faldaprevir plus Pegylated Interferon α-2a and Ribavirin in Treatment-Naive Hepatitis C Virus Genotype 1-Infected Patients. Antimicrob Agents Chemother 2014;58:3429-3436.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 3429-3436
    • Dieterich, D.1    Asselah, T.2    Guyader, D.3
  • 53
    • 84878980518 scopus 로고    scopus 로고
    • Faldaprevir combined with peginterferon alfa-2a and ribavirin in chronic hepatitis C virus genotype-1 patients with prior nonresponse: SILEN-C2 trial
    • Sulkowski MS, Bourlière M, Bronowicki JP, et al. Faldaprevir combined with peginterferon alfa-2a and ribavirin in chronic hepatitis C virus genotype-1 patients with prior nonresponse: SILEN-C2 trial. Hepatology 2013;57:2155-2163.
    • (2013) Hepatology , vol.57 , pp. 2155-2163
    • Sulkowski, M.S.1    Bourlière, M.2    Bronowicki, J.P.3
  • 54
    • 84896737806 scopus 로고    scopus 로고
    • A pooled analysis of two randomized double blind placebo-controlled phase III trials (START Verso 1 and 2) of faldaprevir plus pegylated interferon a-2a and ribavirin in treatment naïve patients with chronic hepatitis C genotype 1 infection background
    • Jensen D, Asselah T, Dieterich DT, et al. A pooled analysis of two randomized double blind placebo-controlled phase III trials (START Verso 1 and 2) of faldaprevir plus pegylated interferon a-2a and ribavirin in treatment naïve patients with chronic hepatitis C genotype 1 infection background. Hepatology 2013;58:734.
    • (2013) Hepatology , vol.58 , pp. 734
    • Jensen, D.1    Asselah, T.2    Dieterich, D.T.3
  • 55
    • 84879247798 scopus 로고    scopus 로고
    • Faldaprevir plus pegylated interferon a-2a and ribavirin in chronic HCV genotype 1 treatment naïve patients. Final results from STARTVERSO1 a randomized double blind placebo-controlled phase III trial
    • Ferenci P, Asselah T, Foster GR, et al. Faldaprevir plus pegylated interferon a-2a and ribavirin in chronic HCV genotype 1 treatment naïve patients. Final results from STARTVERSO1 a randomized double blind placebo-controlled phase III trial. J Hepatol 2013;58:S569-S570.
    • (2013) J Hepatol , vol.58 , pp. S569-S570
    • Ferenci, P.1    Asselah, T.2    Foster, G.R.3
  • 56
    • 84921032324 scopus 로고    scopus 로고
    • DAUPHINE: A randomized phase II study of danoprevir/ritonavir plus peginterferon alpha-2a/ ribavirin in HCV genotypes 1 or 4
    • Everson G, Cooper C, Hézode C, et al. DAUPHINE: a randomized phase II study of danoprevir/ritonavir plus peginterferon alpha-2a/ ribavirin in HCV genotypes 1 or 4. Liver Int 2014, doi: 10.1111/liv.12471. [Epub ahead of print].
    • (2014) Liver Int
    • Everson, G.1    Cooper, C.2    Hézode, C.3
  • 57
    • 84894099866 scopus 로고    scopus 로고
    • Randomized trial of daclatasvir and asunaprevir with or without PegIFN/RBV for hepatitis C virus genotype 1 null responders
    • Lok AS, Gardiner DF, Hézode C, et al. Randomized trial of daclatasvir and asunaprevir with or without PegIFN/RBV for hepatitis C virus genotype 1 null responders. J Hepatol 2014;60:490-499.
    • (2014) J Hepatol , vol.60 , pp. 490-499
    • Lok, A.S.1    Gardiner, D.F.2    Hézode, C.3
  • 58
    • 84881316397 scopus 로고    scopus 로고
    • High SVR rates (SVR4) for 12-week total telaprevir combination therapy in IL28B CC treatment-naives and prior relapsers with G1 chronic hepatitis C: CONCISE interim analysis
    • Nelson DR, Poordad F, Feld JJ, et al. High SVR rates (SVR4) for 12-week total telaprevir combination therapy in IL28B CC treatment-naives and prior relapsers with G1 chronic hepatitis C: CONCISE interim analysis. J Hepatol 2013;58:S362.
    • (2013) J Hepatol , vol.58 , pp. S362
    • Nelson, D.R.1    Poordad, F.2    Feld, J.J.3
  • 59
    • 84907302681 scopus 로고    scopus 로고
    • Treatment of HCV infection with the novel NS3/4A protease inhibitors
    • De luca A, Bianco C, Rossetti B. Treatment of HCV infection with the novel NS3/4A protease inhibitors. Curr Opin Pharmacol 2014;18C:9-17.
    • (2014) Curr Opin Pharmacol , vol.18C , pp. 9-17
    • De Luca, A.1    Bianco, C.2    Rossetti, B.3
  • 60
    • 82455192239 scopus 로고    scopus 로고
    • Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: In vitro and in vivo correlations
    • Fridell RA, Wang C, Sun JH, et al. Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations. Hepatology 2011;54:1924-1935.
    • (2011) Hepatology , vol.54 , pp. 1924-1935
    • Fridell, R.A.1    Wang, C.2    Sun, J.H.3
  • 61
    • 84865563661 scopus 로고    scopus 로고
    • MK-7009 Protocol 007 Study Group. Vaniprevir with pegylated interferon alpha-2a and ribavirin in treatment-naïve patients with chronic hepatitis C: A randomized phase II study
    • Manns MP, Gane E, Rodriguez-Torres M, et al; MK-7009 Protocol 007 Study Group. Vaniprevir with pegylated interferon alpha-2a and ribavirin in treatment-naïve patients with chronic hepatitis C: a randomized phase II study. Hepatology 2012;56:884-893.
    • (2012) Hepatology , vol.56 , pp. 884-893
    • Manns, M.P.1    Gane, E.2    Rodriguez-Torres, M.3
  • 62
    • 84879189258 scopus 로고    scopus 로고
    • A phase 2B study of MK-7009 (vaniprevir) in patients with genotype 1 HCV infection who have failed previous pegylated interferon and ribavirin treatment
    • Lawitz E, Rodriguez-Torres M, Stoehr A, et al. A phase 2B study of MK-7009 (vaniprevir) in patients with genotype 1 HCV infection who have failed previous pegylated interferon and ribavirin treatment. J Hepatol 2013;59:11-17.
    • (2013) J Hepatol , vol.59 , pp. 11-17
    • Lawitz, E.1    Rodriguez-Torres, M.2    Stoehr, A.3
  • 63
    • 84901244528 scopus 로고    scopus 로고
    • Combination of vaniprevir with peginterferon and ribavirin significantly increases the rate of SVR in treatment-experienced patients with chronic HCV genotype 1 infection and cirrhosis
    • Rodriguez-Torres M, Stoehr A, Gane EJ, et al. Combination of vaniprevir with peginterferon and ribavirin significantly increases the rate of SVR in treatment-experienced patients with chronic HCV genotype 1 infection and cirrhosis. Clin Gastroenterol Hepatol 2014;12:1029-1037.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 1029-1037
    • Rodriguez-Torres, M.1    Stoehr, A.2    Gane, E.J.3
  • 64
    • 84878119417 scopus 로고    scopus 로고
    • Daclatasvir, an NS5A replication complex inhibitor, combined with Peginterferon alfa-2a and ribavirin in treatment naïve HCV genotype 1 and 4 subjects: Phase 2b COMMAND 1 SVR12 results
    • Hezode C, Hirschfield GM, Ghesquiere W, et al. Daclatasvir, an NS5A replication complex inhibitor, combined with Peginterferon alfa-2a and ribavirin in treatment naïve HCV genotype 1 and 4 subjects: phase 2b COMMAND 1 SVR12 results. Hepatology 2012;56:553A-555A.
    • (2012) Hepatology , vol.56 , pp. 553A-555A
    • Hezode, C.1    Hirschfield, G.M.2    Ghesquiere, W.3
  • 65
    • 84884223989 scopus 로고    scopus 로고
    • Daclatasvir combined with Peginterferon alfa-2a and ribavirin for 12 or 16 weeks in patients with HCV genotype 2 or 3 infection: COMMAND Gt2/3 study
    • Dore GJ, Lawitz E, Hezode E, et al. Daclatasvir combined with Peginterferon alfa-2a and ribavirin for 12 or 16 weeks in patients with HCV genotype 2 or 3 infection: COMMAND Gt2/3 study. J Hepatol 2013;58(Suppl 1):S570-S571.
    • (2013) J Hepatol , vol.58 , pp. S570-S571
    • Dore, G.J.1    Lawitz, E.2    Hezode, E.3
  • 66
    • 84906350125 scopus 로고    scopus 로고
    • Daclatasvir combined with peginterferon alfa-2a and ribavirin in Japanese patients infected with hepatitis C genotype 1
    • Izumi N, Yokosuka O, Kawada N, et al. Daclatasvir combined with peginterferon alfa-2a and ribavirin in Japanese patients infected with hepatitis C genotype 1. Antivir Ther 2014;19:501-510.
    • (2014) Antivir Ther , vol.19 , pp. 501-510
    • Izumi, N.1    Yokosuka, O.2    Kawada, N.3
  • 67
    • 84906344728 scopus 로고    scopus 로고
    • A randomized trial of daclatasvir with peginterferon alfa-2b and ribavirin for HCV genotype 1 infection
    • Suzuki F, Toyota J, Ikeda K, et al. A randomized trial of daclatasvir with peginterferon alfa-2b and ribavirin for HCV genotype 1 infection. Antivir Ther 2014;19:491-499.
    • (2014) Antivir Ther , vol.19 , pp. 491-499
    • Suzuki, F.1    Toyota, J.2    Ikeda, K.3
  • 68
    • 84890973133 scopus 로고    scopus 로고
    • Randomized study of asunaprevir plus pegylated interferon-α and ribavirin for previously untreated genotype 1 chronic hepatitis C
    • Bronowicki JP, Pol S, Thuluvath PJ, et al. Randomized study of asunaprevir plus pegylated interferon-α and ribavirin for previously untreated genotype 1 chronic hepatitis C. Antivir Ther 2013;18:885-893.
    • (2013) Antivir Ther , vol.18 , pp. 885-893
    • Bronowicki, J.P.1    Pol, S.2    Thuluvath, P.J.3
  • 69
    • 84893454551 scopus 로고    scopus 로고
    • Efficacy and safety of danoprevir-ritonavir plus peginterferon alfa-2a-ribavirin in hepatitis C virus genotype 1 prior null responders
    • Gane EJ, Rouzier R, Wiercinska-Drapalo A, et al. Efficacy and safety of danoprevir-ritonavir plus peginterferon alfa-2a-ribavirin in hepatitis C virus genotype 1 prior null responders. Antimicrob Agents Chemother 2014;58:1136-1145.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 1136-1145
    • Gane, E.J.1    Rouzier, R.2    Wiercinska-Drapalo, A.3
  • 70
    • 84884411153 scopus 로고    scopus 로고
    • Randomized controlled trial of danoprevir plus peginterferon alfa-2a and ribavirin in treatment-naïve patients with hepatitis C virus genotype 1 infection
    • Marcellin P, Cooper C, Balart L, et al. Randomized controlled trial of danoprevir plus peginterferon alfa-2a and ribavirin in treatment-naïve patients with hepatitis C virus genotype 1 infection. Gastroenterology 2013;145:790-800.
    • (2013) Gastroenterology , vol.145 , pp. 790-800
    • Marcellin, P.1    Cooper, C.2    Balart, L.3
  • 71
    • 84904708963 scopus 로고    scopus 로고
    • The Combination of MK-5172, peginterferon, and ribavirin is effective in treatment-naive patients with hepatitis C virus genotype 1 infection without cirrhosis
    • Manns MP, Vierling JM, Bacon BR, et al. The Combination of MK-5172, peginterferon, and ribavirin is effective in treatment-naive patients with hepatitis C virus genotype 1 infection without cirrhosis. Gastroenterology 2014;147:366-376.e6.
    • (2014) Gastroenterology , vol.147 , Issue.6 , pp. 366-376
    • Manns, M.P.1    Vierling, J.M.2    Bacon, B.R.3
  • 72
    • 84881025292 scopus 로고    scopus 로고
    • JUMP-C investigators. JUMP-C: A randomized trial of mericitabine plus pegylated interferon alpha- 2a/ribavirin for 24 weeks in treatment-naïve HCV genotype 1/4 patients
    • Pockros PJ, Jensen D, Tsai N, et al. JUMP-C investigators. JUMP-C: a randomized trial of mericitabine plus pegylated interferon alpha- 2a/ribavirin for 24 weeks in treatment-naïve HCV genotype 1/4 patients. Hepatology 2013;58:514-523.
    • (2013) Hepatology , vol.58 , pp. 514-523
    • Pockros, P.J.1    Jensen, D.2    Tsai, N.3
  • 73
    • 84879211393 scopus 로고    scopus 로고
    • PROPEL investigators. PROPEL: A randomized trial of mericitabine plus peginterferon alpha-2a/ribavirin therapy in treatment-naïve HCV genotype 1/4 patients
    • Wedemeyer H, Jensen D, Herring R Jr, et al. PROPEL investigators. PROPEL: a randomized trial of mericitabine plus peginterferon alpha-2a/ribavirin therapy in treatment-naïve HCV genotype 1/4 patients. Hepatology 2013;58:524-537.
    • (2013) Hepatology , vol.58 , pp. 524-537
    • Wedemeyer, H.1    Jensen, D.2    Herring, R.3
  • 74
    • 84865418147 scopus 로고    scopus 로고
    • VX-222/telaprevir in combination with peginterferon-alfa-2a and ribavirin in treatment naïve patients treated for 12 weeks. Zenith study. SVR12 interim analysis
    • Nelson DR, Gane EJ, Jacobson I., et al. VX-222/telaprevir in combination with peginterferon-alfa-2a and ribavirin in treatment naïve patients treated for 12 weeks. Zenith study. SVR12 interim analysis. Hepatology 2011;54:S1442.
    • (2011) Hepatology , vol.54 , pp. S1442
    • Nelson, D.R.1    Gane, E.J.2    Jacobson, I.3
  • 75
    • 84878136958 scopus 로고    scopus 로고
    • Up to 100% SVR4 rates with ritonavir-boosted danoprevir mericitabine and ribavirin +/- peginterferon-alfa-2a in HCV genotype 1-infected partial and null responders: Results from the NATTERHORN study
    • Feld JJ. Jacobson I. Jensen DM. et al. Up to 100% SVR4 rates with ritonavir-boosted danoprevir mericitabine and ribavirin +/- peginterferon-alfa-2a in HCV genotype 1-infected partial and null responders: results from the NATTERHORN study. Hepatology 2012;56:S231.
    • (2012) Hepatology , vol.56 , pp. S231
    • Feld, J.J.1    Jacobson, I.2    Jensen, D.M.3
  • 76
    • 84881314421 scopus 로고    scopus 로고
    • GS-5885 + GS-9451 + peginterferon and ribavirin for 6 or 12 weeks achieves high SVR rates in treatment naïve genotype 1 IL28B CC patients
    • Thompson A, Han S, Shiffman MI. et al. GS-5885 + GS-9451 + peginterferon and ribavirin for 6 or 12 weeks achieves high SVR rates in treatment naïve genotype 1 IL28B CC patients. J Hepatol 2013;58:S29.
    • (2013) J Hepatol , vol.58 , pp. S29
    • Thompson, A.1    Han, S.2    Shiffman, M.I.3
  • 77
    • 84892168710 scopus 로고    scopus 로고
    • Combination of the NS5A inhibitor, GS-5885, the NS3 protease inhibitor GS-9451 and pegylated interferon plus ribavirin in treatment experienced patients with genotype 1 hepatitis C infection
    • Everson GT, Di Bisceglie AM, Vierling JM, et al. Combination of the NS5A inhibitor, GS-5885, the NS3 protease inhibitor GS-9451 and pegylated interferon plus ribavirin in treatment experienced patients with genotype 1 hepatitis C infection. J Hepatol 2013;58:S6.
    • (2013) J Hepatol , vol.58 , pp. S6
    • Everson, G.T.1    Di Bisceglie, A.M.2    Vierling, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.