Inappropriate prescribing in a large community-dwelling older population: A focus on prevalence and how it relates to patient and physician characteristics

Journal of Clinical Pharmacy and Therapeutics

Volumn 40, Issue 1, 2015, Pages 7-13

  Amos, T B ^a   Keith, S W ^b   Del Canale, S ^c   Orsi, P ^d   Maggio, M ^e   Baccarini, S ^d   Gonzi, G ^f   Liu, M ^b   Maio, V ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c Parma Local Health Authority   (Italy)

^d Vaio Hospital   (Italy)

^e UNIVERSITY OF PARMA   (Italy)

^f UNIVERSITY HOSPITAL OF PARMA   (Italy)

Author keywords

aging; general practitioner; medication; patient characteristics; practices; prescribing

Indexed keywords

AMIODARONE; AMITRIPTYLINE; ANTIARRHYTHMIC AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; CHLORPROPAMIDE; CITALOPRAM; CLONIDINE; DIGOXIN; DISOPYRAMIDE; DOXAZOSIN; ESCITALOPRAM; ESTROGEN; FLUOXETINE; INDOMETACIN; KETOROLAC; METHYLDOPA; NEUROLEPTIC AGENT; NIFEDIPINE; NONSTEROID ANTIINFLAMMATORY AGENT; ORPHENADRINE; PENTAZOCINE; PROTON PUMP INHIBITOR; SPIRONOLACTONE; TESTOSTERONE; TICLOPIDINE;

AGED; ARTICLE; COHORT ANALYSIS; FEMALE; GENERAL PRACTITIONER; GROUPS BY AGE; HUMAN; INAPPROPRIATE PRESCRIBING; ITALY; MAJOR CLINICAL STUDY; MALE; PREVALENCE; REIMBURSEMENT; RETROSPECTIVE STUDY; VERY ELDERLY; AGE DISTRIBUTION; CLINICAL PRACTICE; DEMOGRAPHY; SEX RATIO; STATISTICS AND NUMERICAL DATA;

AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; COHORT STUDIES; FEMALE; GENERAL PRACTITIONERS; HUMANS; INAPPROPRIATE PRESCRIBING; ITALY; MALE; PHYSICIAN'S PRACTICE PATTERNS; PREVALENCE; RESIDENCE CHARACTERISTICS; RETROSPECTIVE STUDIES; SEX DISTRIBUTION;

EID: 84920391817     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/jcpt.12212     Document Type: Article

References (44)

1. Kaufmann CP, Tremp R, Hersberger KE, Lampert ML,. Inappropriate prescribing: a systematic overview of published assessment tools. Eur J Clin Pharmacol, 2014; 70: 1-11.
2. Beers MH,. Explicit criteria for determining potentially inappropriate medication use by the elderly. An update. Arch Intern Med, 1997; 157: 1531-1536.
3. Dimitrow MS, Airaksinen MS, Kivela SL, Lyles A, Leikola SN,. Comparison of prescribing criteria to evaluate the appropriateness of drug treatment in individuals aged 65 and older: a systematic review. J Am Geriatr Soc, 2011; 59: 1521-1530.
4. Marcum ZA, Hanlon JT,. Commentary on the new american geriatric society beers criteria for potentially inappropriate medication use in older adults. Am J Geriatr Pharmacother, 2012; 10: 151-159.
5. Maio V, Del Canale S, Abouzaid S, GAP Investigators. Using explicit criteria to evaluate the quality of prescribing in elderly Italian outpatients: a cohort study. J Clin Pharm Ther, 2010; 35: 219-229.
6. Keith SW, Maio V, Dudash K, Templin M, Del Canale S,. A physician-focused intervention to reduce potentially inappropriate medication prescribing in older people: a 3-year, italian, prospective, proof-of-concept study. Drugs Aging, 2013; 30: 119-127.
7. Lopatto J, Keith SW, Del Canale S, Templin M, Maio V,. Evaluating sustained quality improvements: long-term effectiveness of a physician-focused intervention to reduce potentially inappropriate medication prescribing in an older population. J Clin Pharm Ther, 2014; 39: 266-271.
8. Clyne B, Bradley MC, Hughes CM, et al,. Addressing potentially inappropriate prescribing in older patients: development and pilot study of an intervention in primary care (the OPTI-SCRIPT study). BMC Health Serv Res, 2013; 13: 307-6963-13-307
9. Holmes HM, Luo R, Kuo YF, Baillargeon J, Goodwin JS,. Association of potentially inappropriate medication use with patient and prescriber characteristics in medicare part D. Pharmacoepidemiol Drug Saf, 2013; 22: 728-734.
10. Howard M, Dolovich L, Kaczorowski J, Sellors C, Sellors J,. Prescribing of potentially inappropriate medications to elderly people. Fam Pract, 2004; 21: 244-247.
11. Lo SA, Donatini A, Orzella L, Cicchetti A, Profili S, Maresso A,. Italy: Health system review [health systems in transition] copenhagen. Denmark: European observatory on health care systems. World Health Organization Regional Office for Europe. 2009.
12. Squires D,. International profiles of health care systems: The italian health care system, 2009. 2010.
13. Louis DZ, Yuen EJ, Maio V, Rabinowitz C, Robeson M, Smith KD, Gonnella JS,. A population-based longitudinal healthcare database in the emilia-romagna region, Italy: a resource for planning and research. Health Policy Newsletter, 2005; 18: 6.
14. Fick DM, Semla TP,. 2012 American geriatrics society beers criteria: new year, new criteria, new perspective. J Am Geriatr Soc, 2012; 60: 614-615.
15. Campbell SM, Cantrill JA,. Consensus methods in prescribing research. J Clin Pharm Ther, 2001; 26: 5-14.
16. Guaraldo L, Cano FG, Damasceno GS, Rozenfeld S, Inappropriate medication use among the elderly: a systematic review of administrative databases. BMC Geriatr, 2011; 11: 79-2318-11-79.
17. Barkin RL, Beckerman M, Blum SL, Clark FM, Koh EK, Wu DS,. Should nonsteroidal anti-inflammatory drugs (NSAIDs) be prescribed to the older adult? Drugs Aging, 2010; 27: 775-789.
18. Public health advisory-FDA announces important changes and additional warnings for COX-2 selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs). Available at: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm150314.htm. Accessed March 14, 2014.
19. Agenzia italiana del farmaco. piroxicam: Ulteriori restrizioni e avvertenze sulla sicurezza. bollettino di informazione sui farmaci. anno XIV, N.6, 2007. Availabe at: http://www.agenziafarmaco.gov.it/it/content/piroxicam-ulteriori-restrizioni-e-avvertenze-sulla-sicurezza. Accessed March 11, 2014.
20. Assessment report for non-steroidal anti-inflammatory drugs (NSAIDs) and cardiovascular risk. 2012;EMA/696137/2012.
21. Atti parlamentari. camera dei deputati. relazione sull'Attuazione delle disposizioni per garantire l'Accesso alle cure palliative e alla terapia del dolore. Available at: http://www.salute.gov.it/imgs/C-17-pubblicazioni-1487-allegato.pdf. Accessed March 11, 2014.
22. Appropriatezza prescrittiva della ticlopidina. AIFA-Agenzia Italiana del Farmaco. Bollettino D'informazione sui Farmaci. 2008;4:172.
23. Kwok CS, Arthur AK, Anibueze CI, Singh S, Cavallazzi R, Loke YK,. Risk of clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis. Am J Gastroenterol, 2012; 107: 1011-1019.
24. Lo WK, Chan WW,. Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: a meta-analysis. Clin Gastroenterol Hepatol, 2013; 11: 483-490.
25. Yu EW, Bauer SR, Bain PA, Bauer DC,. Proton pump inhibitors and risk of fractures: a meta-analysis of 11 international studies. Am J Med, 2011; 124: 519-526.
26. Bell JS, Strandberg TE, Teramura-Gronblad M, Laurila JV, Tilvis RS, Pitkala KH,. Use of proton pump inhibitors and mortality among institutionalized older people. Arch Intern Med, 2010; 170: 1604-1605.
27. The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major cardiovascular events in hypertensive patients randomized to doxazosin vs. chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT collaborative research group. JAMA, 2000; 283: 1967-1975.
28. Wykretowicz A, Guzik P, Wysocki H,. Doxazosin in the current treatment of hypertension. Expert Opin Pharmacother, 2008; 9: 625-633.
29. Camm AJ, Lip GY, De Caterina R, et al,. 2012 focused update of the ESC guidelines for the management of atrial fibrillation: an update of the 2010 ESC guidelines for the management of atrial fibrillation-developed with the special contribution of the European heart rhythm association. Europace, 2012; 14: 1385-1413.
30. Freemantle N, Lafuente-Lafuente C, Mitchell S, Eckert L, Reynolds M,. Mixed treatment comparison of dronedarone, amiodarone, sotalol, flecainide, and propafenone, for the management of atrial fibrillation. Europace, 2011; 13: 329-345.
31. Lee HC, Tl Huang K, Shen WK, Use of antiarrhythmic drugs in elderly patients. J Geriatr Cardiol, 2011; 8: 184-194.
32. Gurwitz JH,. Polypharmacy: a new paradigm for quality drug therapy in the elderly? Arch Intern Med, 2004; 164: 1957-1959.
33. Nathan A, Goodyer L, Lovejoy A, Rashid A,. 'Brown bag' medication reviews as a means of optimizing patients' use of medication and of identifying potential clinical problems. Fam Pract, 1999; 16: 278-282.
34. Goulding MR,. Inappropriate medication prescribing for elderly ambulatory care patients. Arch Intern Med, 2004; 164: 305-312.
35. Roe CM, McNamara AM, Motheral BR,. Gender- and age-related prescription drug use patterns. Ann Pharmacother, 2002; 36: 30-39.
36. Simoni-Wastila L,. Gender and psychotropic drug use. Med Care, 1998; 36: 88-94.
37. Laroche ML, Charmes JP, Nouaille Y, Fourrier A, Merle L,. Impact of hospitalisation in an acute medical geriatric unit on potentially inappropriate medication use. Drugs Aging, 2006; 23: 49-59.
38. Maio V, Jutkowitz E, Herrera K, Abouzaid S, Negri G, Del Canale S,. Appropriate medication prescribing in elderly patients: how knowledgeable are primary care physicians? A survey study in Parma, Italy. J Clin Pharm Ther, 2011; 36: 468-480.
39. Visca M, Donatini A, Gini R, et al,. Group versus single handed primary care: a performance evaluation of the care delivered to chronic patients by Italian GPs. Health Policy, 2013; 113: 188-198.
40. Henderson JT, Weisman CS,. Physician gender effects on preventive screening and counseling: an analysis of male and female patients' health care experiences. Med Care, 2001; 39: 1281-1292.
41. Miller RH, Bovbjerg RR,. Efforts to improve patient safety in large, capitated medical groups: description and conceptual model. J Health Polit Policy Law, 2002; 27: 401-440.
42. Reschovsky J, Reed M, Blumenthal D, Landon B,. Physicians' assessments of their ability to provide high-quality care in a changing health care system. Med Care, 2001; 39: 254-269.
43. Pham HH, Schrag D, Hargraves JL, Bach PB,. Delivery of preventive services to older adults by primary care physicians. JAMA, 2005; 294: 473-481.
44. Audet AM, Doty MM, Shamasdin J, Schoenbaum SC,. Measure, learn, and improve: physicians' involvement in quality improvement. Health Aff (Millwood), 2005; 24: 843-853.