What happens when people discontinue taking medications? Lessons from COMBINE

Addiction

Volumn 109, Issue 12, 2014, Pages 2044-2052

  Stout, Robert L ^a   Braciszewski, Jordan M ^a   Subbaraman, Meenakshi Sabina ^b   Kranzler, Henry R ^c   O'Malley, Stephanie S ^d   Falk, Daniel ^e   Anton, Raymond ^f   Bain, Earle ^g   Canuso, Carla ^h   de Somer, Marc ⁱ   Dennehy, Ellen ^j   Graham, Jay ^k   Kosten, Thomas ^l   Mann, Karl ^m   McCann, David ⁿ   Meulien, Didier ^o   Meyer, Roger ^p   O'Brien, Charles ^c   Palumbo, Joseph ^h   Permutt, Thomas ^q   Rendenbach Mueller, Beatrice ^g   Robinson, Rebecca ^r   Silverman, Bernard ⁱ   Torup, Lars ^o   Van Meter, Susan ^k   Winchell, Celia ^q   Wong, Conrad ^j   more..

^a Pacific Institute for Research and Evaluation   (United States)

^b ALCOHOL RESEARCH GROUP   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d YALE UNIVERSITY   (United States)

^e NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^f MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^g ABBOTT LABORATORIES   (United States)

^h JOHNSON AND JOHNSON   (United States)

ⁱ Eli Lilly ^*  (Ireland)

^j ELI LILLY   (United States)

^k GLAXOSMITHKLINE   (United States)

^l BAYLOR COLLEGE OF MEDICINE   (United States)

^m CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

ⁿ NIDA   (United States)

^o H LUNDBECK A S   (Denmark)

^p Best Practice Management   (United States)

^q CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^r ELI LILLY AND COMPANY   (United States)

more..

Author keywords

Alcohol treatment outcome; Clinical intervention; Imputation; Medication compliance; Medication study; Missing data; Research methods; Statistics

Indexed keywords

ACAMPROSATE; DRUGS USED IN THE TREATMENT OF ADDICTION; NALTREXONE; TAURINE;

ADULT; ALCOHOLISM; ANALOGS AND DERIVATIVES; BEHAVIOR THERAPY; CLINICAL TRIAL; COMBINATION DRUG THERAPY; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DRINKING BEHAVIOR; FEMALE; HUMAN; LONGITUDINAL STUDY; MALE; MEDICATION COMPLIANCE; MIDDLE AGED; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; PATIENT DROPOUT; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; STATISTICS AND NUMERICAL DATA;

ADULT; ALCOHOL DETERRENTS; ALCOHOL DRINKING; ALCOHOLISM; BEHAVIOR THERAPY; COMBINED MODALITY THERAPY; CROSS-SECTIONAL STUDIES; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MEDICATION ADHERENCE; MIDDLE AGED; NALTREXONE; PATIENT DROPOUTS; RECURRENCE; TAURINE;

EID: 84920381853     PISSN: 09652140     EISSN: 13600443     Source Type: Journal    
DOI: 10.1111/add.12700     Document Type: Article

References (21)

1. Peduzzi P., Henderson W., Hartigan P., Lavori P. Analysis of randomized controlled trials. Epidemiol Rev 2002; 24: 26-38.
2. Gurvich E. M., Kenna G. A., Leggio L. Use of novel technology-based techniques to improve alcohol-related outcomes in clinical trials. Alcohol Alcohol 2013; 48: 712-719.
3. Koeter M. W. J., van den Brink W., Lehert P. Effect of early and late compliance on the effectiveness of acamprosate in the treatment of alcohol dependence. J Subst Abuse Treat 2010; 39: 218-226.
4. Rounsaville B. J., Rosen M., Carroll K. M. Contingency management to enhance medication compliance in addicts. In: Higgins S. T., Silverman K., Heil S. H., editors. Contingency Management in the Treatment of Substance Use Disorders: A Science-Based Treatment Innovation. New York, NY: Guilford Press; 2008, pp. 140-160.
5. Swift R., Oslin D. W., Alexander M., Forman R. Adherence monitoring in naltrexone pharmacotherapy trials: a systematic review. J Stud Alcohol Drugs 2011; 72: 1012-1018.
6. Weiss R. D. Adherence to pharmacotherapy in patients with alcohol and opioid dependence. Addiction 2004; 99: 1382-1392.
7. Johnson B. A., Jasinski D. R., Galloway G. P., Kranzler H. R., Weinreib R., Anton R. F. etal. Ritanserin in the treatment of alcohol dependence-a multi-center clinical trial. Psychopharmacology (Berl) 1996; 128: 206-215.
8. Kranzler H. R., Escobar R., Lee D-K M. E. Elevated rates of early discontinuation from pharmacotherapy trials in alcoholics and drug abusers. Alcohol Clin Exp Res 1996; 20: 16-20.
9. Gueorguieva R., Wu R., Krystal J. H., Donovan D. M., O'Malley S. S. Temporal patterns of adherence to medications and behavioral treatment and their relationship to patient characteristics and treatment response. Addict Behav 2013; 38: 2119-2127.
10. Pettinati H. M., Volpicelli J. R., Pierce J. J. D., O'Brien C. P. Improving naltrexone response: an intervention for medical practitioners to enhance medication compliance in alcohol dependent patients. J Addict Dis 2000; 19: 71-83.
11. Arndt S. Stereotyping and the treatment of missing data for drug and alcohol clinical trials. Subst Abuse Treat Prev Policy 2009; 4: 2.
12. Oslin D. W., Lynch K. G., Pettinati H. M., Kampman K. M., Gariti P., Gelfand L. etal. A placebo-controlled randomized clinical trial of naltrexone in the context of different levels of psychosocial intervention. Alcohol Clin Exp Res 2008; 32: 1299-1308.
13. Hallgren K. A., Witkiewitz K. Missing data in alcohol clinical trials: a comparison of methods. Alcohol Clin Exp Res 2013; 37: 2152-2160.
14. Miller W. R. Form 90: A Structured Assessment Interview for Drinking and Related Behaviors. Vol 5. Bethesda, MD: US Department of Health and Human Services; 1996.
15. Anton R. F., O'Malley S. S., Ciraulo D. A., Cisler R. A., Couper D., Donovan D. M. etal. Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial. JAMA 2006; 295: 2003-2017.
16. Combine Study Research Group. Testing combined pharmacotherapies and behavioral interventions in alcohol dependence: rationale and methods. Alcohol Clin Exp Res 2003; 27: 1107-1122.
17. Combine Study Research Group. Testing combined pharmacotherapies and behavioral interventions for alcohol dependence (the COMBINE study): a pilot feasibility study. Alcohol Clin Exp Res 2003; 27: 1123-1131.
18. Zweben A., Pettinati H. M., Weiss R. D., Youngblood M., Cox C. E., Mattson M. E. etal. Relationship between medication adherence and treatment outcomes: the COMBINE study. Alcohol Clin Exp Res 2008; 32: 1661-1669.
19. Panel on Handling Missing Data in Clinical Trials, National Research Council. The Prevention and Treatment of Missing Data in Clinical Trials. Washington, DC: The National Academies Press; 2010.
20. Epstein E. E., Labouvie E., McCrady B. S., Jensen N. K., Hayaki J. A multi-site study of alcohol subtypes: classification and overlap of unidimensional and multi-dimensional typologies. Addiction 2002; 97: 1041-1053.
21. Anton R. F., Litten R. Z., Falk D. E., Palumbo J. M., Bartus R. T., Robinson R. L. etal. The Alcohol Clinical Trials Initiative (ACTIVE): purpose and goals for assessing important and salient issues for medications development in alcohol use disorders. Neuropsychopharmacology 2012; 37: 402-411.